4 Factors Affecting Solubility of Drugs

Bringing a new drug—or a new formula—to market is an exciting time for pharmaceutical companies, but getting the formulation correct can be challenging. Low aqueous solubility is a top concern encountered with formulation development of new chemical entities (NCEs). Improper drug solubility can lead to suboptimal drug delivery and absorption, resulting in ineffective drug efficacy and side effects. That's why solubility of drugs must be evaluated in the early stages of drug discovery.