Anti-fibrotic properties of APPLIVER on in vitro models of non-alcoholic steatohepatitis
In collaboration with the research groups of Fondazione Italiana Fegato Onlus (FIF) APPLIVER™ was tested in in vitro model of non-alcoholic fatty liver disease (NAFLD), characterized to develop fibrosis.
- Reduction of collagen both in terms of gene expression and extracellular content (fibrosis)
- Downregulation in TNF-alpha