Class 3 Atropisomers in Focus: Custom Manufacturing to Capture Therapeutic Selectivity in Oncology

Atropisomers are axially chiral molecules resulting from restricted rotation around a single bond, typically between two sp²-hybridized atoms. Once overlooked in drug discovery, they are now gaining attention due to the potential for one isomer to exhibit significantly greater biological activity than its counterpart. Isolating the active isomer can enhance drug efficacy and specificity while minimizing off-target effects.

In this webinar, a three-fold strategy will be discussed that includes technologies for which SK pharmteco has extensive experience: 

- Construction of biaryl moieties using Suzuki couplings, integral structural components in most atropisomers. - Separation of the enantiomers using Simulated Moving Bed (SMB) chromatography. 
- Racemization of the undesired enantiomer under continuous flow conditions coupled with separation of the enantiomers using SMB.