Antibody-drug conjugate (ADC) linkers

At SigutLabs (Prague, EU), we help biotech companies and pharma partners design, synthesize, and scale custom antibody-drug conjugate (ADC) linkers tailored for optimal performance. Our core competencies include: Custom design of cleavable and non-cleavable linkers, including traceless/self-immolative designs that release the payload cleanly inside target cells. Full synthetic chemistry services: novel linker motifs, medicinal chemistry optimization, and freedom-to-operate. Lab-to-industry scale-up and quality control, ensuring high purity, reproducibility, and readiness for downstream development or manufacturing. With a PhD-led team, rapid turnaround times, and a track record of accelerating lead selection via linker innovation, we partner with you to reduce risk, protect IP, and speed up the development of safer, more effective ADCs.