Antibody Humanization Service

Antibody Humanization Service
Product Description

Research in the production of monoclonal antibodies is a key part of antibody humanization. The process of converting murine antibodies into human antibodies is called antibody humanization. 

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ALPHA LIFETECH INC.

  • Country/Region:
    United States
  • On CPHI since:
    2023
  • Certificates:
    1
  • Employees:
    25 - 49
Company types
Contract Research Organisation (CRO)
Contract Service
Wholesale/Retail
Primary activities
Biopharmaceutical
View company profile
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Specifications
  • Details
    Research in the production of monoclonal antibodies is a key part of antibody humanization. The process of converting murine antibodies into human antibodies is called antibody humanization. 


    Initial monoclonal antibody used in clinical practice was mouse-derived monoclonal antibodies. However, there were limitations to using mouse-derived antibodies because of differences in human and mouse species. While murine antibodies can bind to specific target antigens and are able to bind to them, they do not activate human immune system such as complement-dependent cytotoxicity and antibody-dependent cell-mediated cytotoxicity (CDC). Therefore, antigen-antibody reactions cannot take place normally. However, murine antibodies that enter the human body may be considered exogenous proteins. This can cause the immune system to produce specific antibodies using mouse antigens (i.e. Human anti-mo...
  • Selling Points
    Quality Service; -- Advanced Algorithm for Aligning and Grafting of CDRs Affinity Guarantee

    -- Antibody humanization from a broad range of parental species including mouse, rat, rabbit, llama and avian scFvs, Fabs and other antibodies humanized

    -- A human antibody database and a proprietary method are used to analyze and design humanized antibodies.

    -- Flexible packages to work in synergy with your team: choose the number of humanized variants you would like to design from 9 to 25 combinations of VH and VL sequences.

  • Model
    services
  • Supplied from
    United States
  • Measured In
    US$
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ALPHA LIFETECH INC.

  • Country/Region:
    United States
  • On CPHI since:
    2023
  • Certificates:
    1
  • Employees:
    25 - 49
Company types
Contract Research Organisation (CRO)
Contract Service
Wholesale/Retail
Primary activities
Biopharmaceutical
View company profile

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