Antrolin

nifedipine + lidocaine hydrochloride cream for rectal use. Therapeutic indications:  
 •Anal fissure 
 •Proctalgia generally associated with anal sphincter hypertonia
Nifedipine inhibits the flow of calcium ions to smooth muscle of the anal sphincter acting as muscle relaxant, anti-inflammatory agent and regulator of microcirculation.
Lidocaine prevents the propagation of the pain stimulus having an analgesic role.
Antrolin demonstrated:
 - a synergetic mechanism of action mediated by nifedipine and lidocaine
 - clinical remission of thrombosed hemorrhoids and post-hemorrhoidectomy pain relief
 - to be effective in healing anal fissures
 - a good tolerability profile even when applied to injured anorectal mucosa