Celecoxib

Celecoxib is a selective cyclooxygenase-2 (COX-2) inhibitor belonging to the nonsteroidal anti-inflammatory drug (NSAID) class, uniquely identified by its chemical formula C₁₇H₁₄F₃N₃O₂S. It is commercially formulated as an oral medication available in capsule strengths of 50 mg, 100 mg, 200 mg, and 400 mg, as well as specialized oral liquid solutions. The active drug substance possesses a sulfonamide functional group, which dictates that its inactive excipient matrices often include lactose monohydrate, gelatin, magnesium stearate, povidone, and sodium lauryl sulfate. Following oral ingestion, celecoxib demonstrates rapid absorption with an onset of action occurring within 60 minutes and reaches peak plasma concentration levels within approximately 3 hours. It exhibits an elimination half-life of roughly 11 hours, metabolized primarily by the liver enzyme CYP2C9 and excreted through feces and urine. Applications: Osteoarthritis ManagementRheumatoid Arthritis TreatmentJuven...