Disease Activity Models/Tissue Culture

MedPharm has developed proprietary models relevant for major disease areas such as psoriasis, atopic dermatitis, onychomycosis and continue to develop new ones through our dedicated innovation group. These sophisticated ex vivo experiments provide additional confidence to clients and their investors about how a product might behave in the clinic. Each of MedPharm’s models can be performed on the surface of the skin to model local topical delivery or ‘basolaterally’ from underneath to model systemic delivery, or allow the screening of a number of APIs.

We can keep ex vivo skin biologically functioning in a laboratory for over 14 days to provide more options for looking at long term biological effects, such as repeat dosing. MedPharm has used these PK/PD models to directly help clients mitigate risks, inform API selection, assess new targets, and support marketing claims.