Hydroxyethyl starch 200/0.5 other active pharmaceutical ingredients

Moisture absorption. Freely soluble in hot water, practically insoluble in alcohol, acetone and trichloromethane.

Over the past decade, several cases of acute kidney failure or osmotic nephrosis-like lesions in biopsy specimens have been reported and were thought to be related to hydroxyethyl starch use in the affected patients. To our knowledge, only five systematic studies have been conducted to address this question. The populations studied were quite heterogeneous: three studies (two retrospective and one prospective) evaluated the effects of hydroxyethyl starch exposure in kidney donors on renal function in recipients. One study tested the effects of various fluid replacement regimens on renal function in elderly patients undergoing major abdominal surgery, and one group studied patients in septic shock. Another experiment was done using an animal model. The results from these studies have been conflicting with some implicating hydroxyethyl starch use in deterioration of renal

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China

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