Oligonucleotide CDMO

Fields of Application: Advanced hormone-dependent prostate cancer, Use in reproductive medicine, Endometriosis, Central precocious puberty. Triptorelin Acetate is a potent LHRH agonist. After a transient increase, continuous administration results in downregulation of LH and FSH levels followed by a suppre...

Fields of Application: Advanced hormone-dependent prostate cancer. Triptorelin Pamoate is a potent LHRH agonist. After a transient increase, continuous administration results in downregulation of LH and FSH levels followed by a suppression of ovarian and testicular steroid biosynthesis.

Fields of Application: Diabetes II Active Substance: Exendin-4 (exenatide), a 39-amino acid peptide originally isolated from the salivary glands of the Gila monster (Heloderma suspectum), differs from exendin-3 only in two positions close to the N-terminus. Application of exenatide causes an increa...

(Arg8)-Vasopressin or argipressin is an antidiuretic peptide hormone that plays a key role in maintaining plasma osmolality. The peptide released from the posterior pituitary gland promotes renal tubular reabsorption of water. Argipressin is involved in the control of circadian rhythm, thermoregulation, an...

Icatibant Acetate is a selective competitive antagonist for the bradykinin B2 receptor. It is indicated for the treatment of acute attacks of hereditary angioedema (HAE). HAE is a rare disorder resulting in periodic attacks of acute edema. It is characterized by a deficiency of functional C1 esterase inhib...

Fields of Application: Conjunctivitis.  Antazoline Hydrochloride is an ethylenediamine derivative with antihistaminic properties and is used in conjunction with a vasoconstrictor for ocular allergies.

Fields of Application: Conjunctivitis. Antazoline Hydrochloride is an ethylenediamine derivative with antihistaminic properties and is used in conjunction with a vasoconstrictor for ocular allergies.

Fields of Application: Conjunctivitis. Antazoline Sulsphate is an ethylenediamine derivative with antihistaminic properties and is used in conjunction with a vasoconstrictor for ocular allergies.

Fields of Application: Parkinson's disease. Carbidopa, an aromatic L-amino acid decarboxylase inhibitor, which does not cross the blood-brain barrier, is routinely administered in combination with levodopa to patients with Parkinson’s disease to reduce the peripheral decarboxylation of levodopa to dopamine.

Fields of Application: Anesthesia. Etomidate is a rapid, short acting intravenous anesthetic agent with no analgesic properties and a relative lack of significant hemodynamic and respiratory effects.

Fields of Application: Sedation, Anesthesia. Propofol is an intravenous, short acting anesthetic with rapid onset of action.

In our studies in collaboration with Novo Nordisk, we set out to identify environmentally benign solvents suitable for large-scale SPPS of peptide therapeutics at ambient temperature by assessing reagent solubility, resin swelling, amino acid coupling and Fmoc-removal efficiency in a collection of REACH compatible neat solvents and selected binary solvent mixtures. These studies have shown that binary solvent mixtures are indeed viable alternatives.

Microparticle formulation has been successfully applied in a number of commercial products containing peptides as APIs. The use of nanoparticles for delivering proteins and peptides are still in early stages of development. Discover how Bachem is part of this technology!

The Molecular Hiving™️ technology is especially suitable for the synthesis of peptide ingredients for cosmetic products, as CMR solvents and reagents can entirely be avoided during the manufacturing process.

Learn about the Molecular HivingTM technology, it’s scalability and the substantial advantages regarding efficiency, CMR free synthesis of peptides and greener manufacturing.

Improving the sustainability in the CDMO industry is a multi-facetted approach covering environmental, economic and social tasks while having a strong focus on these areas where a company can make the highest impact. Bachem, the leading manufacturer of peptides and oligonucleotides is a good example for using this approach successfully. By innovating for better manufacturing the company could massively reduce greenhouse gas emissions and solvent consumptions: something that is also of utmost interest when searching for a partner for large-scale production of oligonucleotides and peptides.

As the world’s leading company in the development and production of peptides and oligonucleotides (TIDES), Bachem is a strategic partner for Biotechnology, Pharmaceuticals, Diagnostics, Cosmetics and Life Science research. We work in close collaboration with our customers to ensure the success of their ambitious product development programs.Innovation is one of our key success factors. We are not only producing peptides and oligonucleotides in large quantities in modern industrial production facilities; we are also automating our manufacturing processes wherever possible. We have set new standards in quality, increased efficiency and reduced solvent volumes. There is an increase in the therapeutic use of oligonucleotide-based drugs. The category is also expanding from rare diseases into chronic diseases, with the potential to make a huge difference to more lives. We identified this need for oligonucleotide therapeutics to address larger-scale patient populations and indications. This is driving our commitment and journey in oligonucleotide NCEs: we want to help build a new future.

Philipp Karbach, COO and CFO of AMW, spoke about his experience of working with Bachem: