Other Amino Acid Sidechains

Our enzyme platform creates combinatorial diversity by allowing other aromatic subtrates to act nucleophiles and form other aromatic amino acid analogs.

As peptide therapeutics experience explosive growth, the need to address the pharmacokinetic liabilities of canonical L-amino acids grows. D-amino acids are less susceptible to enzymatic degradation and, when placed appropriately in a peptide or protein sequence, can confer additional selectivity and potency.