Sodium Stearyl
FUMARATE (SSF). It is a tablet lubricant for use in ODT
tablets, in effervescent formulas, or in formulas where the active incompatible
with magnesium stearate. It is an inert, less hydrophobic tablet lubricant than
magnesium stearate. Tablets made with SSF exhibit less sensitivity to
variations in blending time and lubricants levels and have superior hardness
characteristics compared to tablets produced with magnesium stearate.
Compatibility studies comparing SSF to Mag. Stearate showed that SSF was
superior with respect to impact on tablet hardness, ejection forces, friability
and disintegration. The compatibility of blends was reduced when using
magnesium stearate. Ejection forces and friability were also higher for tablets
made using magnesium stearate. The disintegration times were longer for
magnesium stearate and varied with level
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