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Excipients
Excipients Companies (170)
Excipients News
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News CPHI Podcast Series: What to expect from novel excipients?
In this month's episode of the CPHI Podcast Series, Digital Editor Lucy Chard is joined by Nick DiFranco, the Global Market Manager for Novel Pharmaceutical Excipients at Lubrizol Life Science to discuss the ins and outs of excipients, how the...29 Feb 2024 -
News galenIQ: a brand of Beneo
The number one provider for medicated lozenges. Hard-boiled lozenges with galenIQTM 900 - the sweet filler-binder.23 Aug 2023 -
News Roquette expands plant-based excipient portfolio with Crest Cellulose acquisition
Crest Cellulose, an Indian excipient manufacturer, has been acquired by plant-based pharmaceutical excipient provider Roquette in a bid to increase the latter’s presence in the Asia Pacific region.4 Oct 2022 -
News Dr. Paul Lohmann® - Your Partner for high value Mineral Salts
With our expertise in the chemical and physical modification of Minerals and our customer-oriented philosophy, we are the ideal partner to turn your ideas into reality. Meet us at CPHI stand #110F50!27 Sep 2022 -
News Accepting novel excipients for innovative drug development
With the rapid development and manufacturing of new drugs and therapeutics being pushed through the pipeline, excipient manufacturers are navigating a challenging landscape to meet the demand for new and novel excipients.30 Aug 2022 -
News CPHI Podcast Series: The importance of novel excipients for innovative drug development
The latest episode in the CPHI Podcast Series dives into the world of novel excipients and explores their importance for innovative drug development.2 Aug 2022 -
News Hovione and Zerion Pharma collaborate to commercialise low drug solubility solution
By joining forces, the two companies will be able to bring Dispersome to the market faster for novel drug development22 Feb 2022 -
Sponsored Content Croda: Solutions for Your High Value Drug Products
Formulating a drug for parenteral delivery comes with its fair set of challenges. Aside from a high level of sensitivity to external factors like light and heat exposure, these large and complex drugs are prone to degradation when exposed to various ch...11 Feb 2022 -
News UPDATED: COVID-19 Vaccine and Therapeutic Development Tracker
The latest coronavirus updates and developments impacting the global pharmaceutical supply chain. Includes the latest news surrounding the therapeutic developments, updates to vaccines and boosters, and the global pharmaceutical regulations that need t...22 Feb 2024 -
News Roquette to advance drug delivery research with new US Innovation Center
The new facility will focus on the research of excipients for oral dosage forms, drug delivery systems, nutraceutical APIs and innovative pharma ingredients14 Dec 2021 -
News CPHI releases Pharma Trends 2022 report
CPHI has launched its forward-looking pharma trend report for 2022 and it is now available to read on CPHI Online.6 Dec 2021 -
News CPHI Podcast Series: Annual Report 2021 Roundtable
In this special edition podcast, Informa Markets pharma editor Gareth Carpenter speaks to Bikash Chatterjee, CEO at Pharmatech Associates and Dan Stanton, Editor and Founder at BioProcess International about some of the findings in the recently pu...23 Nov 2021 -
News CPHI Worldwide is back, and this time it’s hybrid
A new in-person and online edition of CPHI Worldwide, transforming your event experience.1 Nov 2021 -
Sponsored Content CPHI Webinar: Develop ODTs in a FLASH with UltraBurst™ - Watch On Demand
Catch up on the latest trends and developments in orally disintegrating tablet (ODT) formulation development30 Sep 2021 -
Sponsored Content IFF Pharma Solutions: Paving the Way for Superior Suspensions
Shawn Branning, Global Strategic Marketing Manager at IFF – Pharma Solutions30 Sep 2021 -
News The Top Ten CPHI Discover Company Showcases
CPHI Discover (May 17-28) gave Pharma companies, suppliers and service providers the opportunity to keep potential buyers and partners abreast of the latest news, product information and market trends in the form of free-to-access, downloadable content...3 Jun 2021 -
News COVID-19 Pharma Development Tracker
The latest coronavirus updates and developments impacting the global pharmaceutical supply chain (continued from here)31 May 2021 -
News APIs, excipients and formulation: the bedrock of medical innovation
Our virtual CPHI Discover event (17th-28th May) is just around the corner, full to the brim with three main content tracks. Here, we explore the major trends in APIs, Ingredients & Formulation12 May 2021 -
News CPHI Discover: Earlier partnerships between pharma and excipient manufacturers are the key to success
In the future pharma companies will need to work closer with excipient companies if we are to develop better formulations more quickly6 May 2021 -
News CPHI Discover: Remote excipient audits are on the increase, but we must do more to develop novel excipients
Ahead of the session, Value Added Excipients to Unlock the Potential of APIs, at CPHI Discover on Thursday 18th May – global pharma’s largest ever virtual gathering – we spoke with one of the speakers, Dr Iain Moor...4 May 2021
Excipients Products (500+)
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Product Excipients for Gel Capsules
Enhance your oral formulations with high quality ingredients. Contact us to learn about the excipients in development.
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Product CARBOWAX™ SENTRY™ Polyethylene Glycol (PEG)
CARBOWAX™ SENTRY™ PEGs common applications include: carrier/plasticizer in gel capsules, base for face/neck lotions, providing formulation stability in toothpaste, binder for tablets, shampoo wetting agent, and more. CARBOWAX™ SENTRY™ PEGs are available in average molecular weights ranging from 3... -
Product Tacrolimus capsule
Hangzhou Zhongmei Huadong Pharmaceutical provides wide range of pharmaceutical products which includes tacrolimus capsule. It belongs to formulation category. Indication: for prevention of transplant allograft rejection after liver or renal transplantation. For treatment of transplant allograft rejection f... -
Product MANNITAB™ SD1
Mannitol powder
Binder for direct compression
USP/NF, Ph. Eur., BP, IP
Particle size: 100 µ
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Product We take your products from idea to market success
Hänseler Swiss Pharma is a dedicated partner known for its unwavering commitment to the highest quality standards and innovative strategies. We bring our enthusiasm and Swiss precision to support our partners across the entire value chain, providing custom-tailored solutions for your success in the pha... -
Product Lactalpha 50
Lactalpha 50 is a 50 Mesh pharmaceutical grade sieved lactose conforming with the lactose monohydrate monograph of the current Pharmacopoeias (Ph. Eur., USP-NF and JP). The flowability of Lactalpha 50 makes it efficient as a diluent in capsule or sachet formulation.
Manufactured in Retiers,... -
Product Scientific Support
Selectchemie AG provides a wide range of services including scientific support. Our experienced professionals are at your service at locations in 18 countries to deliver tailor-made solutions according to your needs. Contact us for more information. -
Product Neohesperdin DC Pharma Grade
HTBA Neohesperidin dihydrochalcone Pharma Grade is an excipient used as a sweetener as well as a masking agent for use in oral drug delivery formulations. Neohesperidin dihydrochalcone is an additive derived from the hydrogenation of Neohesperidin, a flavanone that is found in bitter oranges (Citrus aurant... -
Product Montanox™
The MONTANOX™ range is composed of different grades of polysorbates that can be used to solubilize active pharmaceutical and/or biological ingredients and to formulate oil-in-water emulsions for oral, topical and injectable products.
• MONTANOX™20 PHA PREMIUM: Polysorbate 20 • MONTANOX™60 PHA PREMIU... -
Product Hyaluronidase
Hyaluronidase, an enzyme that breaks down hyaluronic acid, has long been used to facilitate the dispersion and absorption of other drugs and to reduce tissue damage in cases of extravasation of a drug. Recombinant human hyaluronidase(rhPH20)developed by BaoPharma(Shanghai)... -
Product Benecel™ HPMC DC
benecel™ hypromellose (hydroxypropyl-methylcellulose or HPMC) is a versatile excipient with a variety of applications. HPMC is the most widely used polymer in hydrophilic matrix systems with widespread use in controlled-release dosage forms.
benecel™ DC HPMC is a surface modified, co-proce... -
Product Dimethyl Sulfoxide (USP, BP, Ph. Eur.) pharma grade CODE 191954
https://www.itwreagents.com/iberia/en/product/dimethyl-sulfoxide-usp-bp-ph-eur-pharma-grade/191954 -
Product Magnesium Stearate
Magnesium stearate is a very fine, light white, precipitated or milled, impalpable powder of low bulk density,having a faint odor of stearic acid and a characteristic taste. The powder is greasy to the touch and readily adheres to the skin. -
Product A-Tab® MD
A-Tab® MD is a co-processed multifunctional excipient that enhances compressibility and simplifies formulations in pharmaceutical and nutraceutical tablets. Improve tablet integrity and hardness, increase manufacturing efficiency, and create smaller tablets with A-Tab® MD (Dicalcium Phosphate Anh... -
Product Ferrous Bisglycinate
Dr. Paul Lohmann GmbH & Co. KGaA offers a wide range of Iron products. Please contact us for more Information. -
Product Macrogol 400 / Hedjuvan-MG400
Hedjuvan-MG400 is a high quality Macrogol 400. The product is produced at Kolb in Hedingen (Switzerland) and is getting tested according to the specifications of the current Ph. Eur. and USP. Kolb has a broad portfolio of non-ionic surfactants with polysorbates having a long successfull trac... -
Product Sodium Hyaluronate - Injection grade
Hyature® is a pharmaceutical grade sodium hyaluronate which can be used as an API or excipient for drugs and medical devices in ophthalmic preparations, intra-articular injections, anti-adhesive preparations, topical preparations for wound healing and soft tissue filler, etc. Hyature® sodium hyalur... -
Product Dispersome® Technology
Dispersome®️ – A green technology for drugs
The Dispersome® technology uses high quality whey protein, an environmentally friendly by-product from cheese production, to improve the solubility and bioavailability of poorly soluble drugs.
To watch explanatory Dispersome... -
Product Polygeline
Serumwerk Bernburg AG is a knowledge base regarding the production of polymer-containing sterile solutions, which can be used for a wide variety of purposes (e.g. volume replacement therapy, adjuvant in the production of vaccines). In recent years, customized formulations based on starch or gelatin have be... -
Product Neohesperidin Dc pharma grade
Our Neohesperidin dihydrochalcone serves as an excipient, fulfilling a dual role as both a sweetener and a masking agent in oral drug delivery formulations. This additive is obtained through the hydrogenation of Neohesperidin, a flavanone naturally occurring in bitter oranges (Citrus aurantium). Its primar... -
Product Calcium Carbonate IP BP USP EP JP Oyster Coral
We are considered in the market to be one of the leading manufacturers and suppliers of this commendable Calcium Carbonate IP BP USP EP JP and OYSTER. Processing of this product is done in accordance with the set norms and guidelines of the chemical industry, utilizing the finest ingredients and ... -
Product Multifunctional Excipients for the Nutraceutical and Pharmaceutical Industry
Our SYLOID® FP silica excipients are a strategic drug development tools in today’s challenging pharmaceutical industry with its demands for improved formulations, bringing new drugs to market faster, and technological advances.
SYLOID® FP silica’s unique, innovative design combine... -
Product Contract R&D and Scale-Up
Actylis offers GMP, biopharma and non-GMP specialty chemical custom ingredient research and development services by generating robust, practical and cost-effective processes for the preparation of specialty chemicals, excipients, and pharmaceutical ingredients. With decades of experienc... -
Product AnyCoat-C® (Hypromellose); HPMC; Hydroxypropylmethylcellulose
AnyCoat-C® is a beloved brand name of the cellulose ether manufactured by LOTTE Fine Chemical.
Properties: white or yellowish white powder; soluble in mixed organic or aqueous solvent; making up transparent film when solvent remove.
Applications: Pharmaceutical excipient, food... -
Product Trusted Ingredients for Pharmaceuticals
With Spectrum Chemical, meet the requirements specified in the USP and NF monographs, which are the official standards for all prescription and over-the-counter medicines, dietary supplements, excipients and other healthcare products.
- Ideal for parenteral, oral, topical and ophthal... -
Product Copovidone VA64/ PVP VA64
Copovidone is a water-soluble polymer resin, white powder, odorless and tasteless, easy to absorb moisture, soluble in water, ethanol and anhydrous alcohols, with good cohesiveness, hygroscopicity, film-forming properties and surface activity.The main application is as follows,
(1)Pharmaceutical field: ... -
Product Sodium Dextran Sulfate 5000
Sodium Dextran Sulfate 5000 suitable for pharmaceutical field with high quality. -
Product Sunvidone ®K/Povidone K series
Huzhou sunflower pharmacetuical co. Ltd offers a wide range of products which includes povidone K series. Feature: it is an aqueous solution of synthetic polymer compound is n vinyl pyrrolidone polymers are linear. It is white to milky white amorphous powder, having a bulk density of 0.4 to 0.6; odor... -
Product Armor Pharma Lactose Monohydrate 80M
Latest launch: ARMOR PHARMA™ lactose monohydrate 80M is a coarse free flowing powder of α-lactose monohydrate with typical Tomahawk shape.
Sieving process gives coarse particles with a narrow particle size distribution enabling very good flowability. This lactose is very often used in capsules a... -
Product Polyglykol
Effective and high-purity ingredients including a complete range of Polyglykols (Macrogols) our universally applicable pharmaceutical polymers, with various molecular weights, supported by CEP certification and DMF type II documentation. -
Product Expansorb
Poly(lactic acid co-glycolic acid) and poly(caprolactone) copolymers used as functional excipients for controlled and slow drug release (weeks to months) with a single injection. -
Product Lactohale® 200
Lactohale® 200 is milled lactose produced with a tightly controlled mean particle size. The size of the particles of Lactohale® 200 can be controlled and but also varied by gentle milling. This means that different D50's can be produced depending on the degree of milling to match the cust... -
Product CROSCARMELLOSE SODIUM
odium croscarmellose is an internally cross-linked sodium carboxymethylcellulose for use as a superdisintegrant in pharmaceutical formulations. -
Product LIGAMED MF-2-V-MB
LIGAMED MF-2-V-MB is our most widely used excipient for the production of tablets and capsules. Its high specific surface area and fine particles offer a high releasing speed during tablet pressing and consistent physical performance of the tablets such as hardness and dissolution profiles. Due to the exce... -
Product Excipient: Super Refined™ DEGEE
Super Refined DEGEE is ideal for use in topical and transdermal applications to enhance the permeation of poorly water-soluble API’s through various layers of the skin, thereby improving drug delivery. It can also be used as a co-solvent in self-emulsifying drug delivery systems (SEDDS), or self-microe... -
Product Lactose Product Portfolio
MEGGLE has it: The Right Lactose Product for all Needs
The world of lactose is our whole world. With this in mind, our products are aligned specifically to your needs and applications. For further information on any product shown here, please see the detailed, individual product brochure ava... -
Product PHARCOCEL - HPMC / Hypromellose / Hydroxy Propyl Methyl Cellulose
Pharmaceutical grades of HPMC will have detailed specification as per specific monograph. All our HPMC grades will be available in powder & granular form. -
Product SNAC CAS 203787-91-1
CAS:203787-91-1
Molecular Weight:301.31337
Molecular Formula: C15H20NNaO4
Appearance: white powder
Application: medical intermediate
Delivery Time: Available goods in stock
Package: inside: douple PE bag outside: paper drum
... -
Product APISAL (Sodium chloride API)
For the exceptionally high requirements in pharmaceutical manufacturing processes, we produce pure pharmaceutical salt exceeding the purity requirements stipulated in the pharmacopoeias. All steps of production, analysis, and quality control comply with these strict principles. APISAL® is obtained from a p... -
Product DRCOAT - Customised Ready to use Coating Pharma Polymer
ENTERIC COATING (AQUEOUS / NON AQUEOUS)IMMIDIATE RELEASE FILM COATING / FILM COATING
MOISTUER BARRIER COATING
PEARSCENT COATING / METTALIC COATING
GLOW COATING / GLOSS COATING
TRANSPARENT COATING
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Product PEARLITOL® - Mannitol
PEARLITOL® Mannitol pharma range is used as a filler and filler/binder as well as a bulk sweetener. The PEARLITOL® range offers a unique blend of exceptional physical and chemical stability and no hygroscopicity.PEARLITOL® can be used in various oral dosage forms in both pharmaceutical and nutraceutic... -
Product Stearic Acid
Stellipress Brand ensures EP/USP compliance of our high purity Micronized Stearic Acid.
Our Stearic Acid is your best choice as a Tablet Lubricant and Magnesium Stearate replacement.
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Product Emulfree Duo
Emulfree® Duo is a ready-to-use system. It has been designed to stabilize the oil phase within a bi-gel, an emerging topical formulation, by ensuring fine and homogeneous dispersion in the aqueous phase. As a PEG-free excipient, it is ideal for sensitive skins and mucosea.
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Product EUDRAGIT® Functional Polymers
Evonik is a global development partner and solutions provider for oral drug delivery. For more than 60 years, we have been providing renowned pharmaceutical and biotech companies with oral drug delivery solutions to help them enhance drug performance, reduce project complexity, increase speed to market and... -
Product SÜDZUCKER COMPRI® M3000
Südzucker COMPRI® M3000 is an agglomerated, directly compressible sugar with parts of maltodextrin. It is suitable e.g. for the production of confectionery or pharmaceutical tablets.
PRODUCT BENEFITS
· Di... -
Product Excipia Experts in excipient analysis, characterization and deformulation / reverse engineering
Excipients can have an important impact on the manufacturability and pharmaceutical performance of a formulation. It’s therefore important to identify and control functionality related characteristics (FRCs) of excipient materials in order to achieve safe, robust and stable products. Expe... -
Product Manufacturing
Custom API Manufacturing, Fermentation, Finished Dosage Form, High Potency, Lipid Nanoparticle, Rare / Orphan, Stability & Release Testing, Sterile Fill Finish, APIs & Intermediates, Fine Chemicals
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Product Hydroxypropylcellulose low-substitued (L-HPC)
Your benefits
- wide range of types to cover various applications and technologies
- produced according to IPEC-GMP guidelines
- Chinese DMF available
- increase the stability of your API in the finished dosage form and enables formulation of smaller table... -
Product TABLUBE - MAGNESIUM STEARATE
Nitika Pharmaceutical Specialities Pvt Ltd provides wide range of excipients which includes Tablube - Magnesium Stearate. It's a type of lubricants and glidants.
Product Description:
· DMF Available
· &nbs... -
Product galenIQ 720
BENEO-Palatinit GmbH provides the pharmaceutical excipient galenIQ™ 720. It is an agglomerated spherical isomalt for direct compression and powder applications. General benefits: high agglomerate stability and excellent flow; morphology ensures homogeneity of the mix and content uniformity; very low compre... -
Product Dexolve
Dexolve is the first generic USP and EP-conform Betadex Sulfobutyl Ether Sodium for:• solubility enhancement (10 to 100,000 fold) • Improvement of chemical stability • Increased bioavailability, facilitated delivery • Reduced aggregation • Moderate irritationor reduced side-effects • Maximiz... -
Product MICCEL-101 (Microcrystalline Cellulose)
Ankit Pulps & Boards Pvt Ltd offers a wide range of products which includes MICCEL 101.
Feature: Wet Granulation and Direct Compressible.
LOD %: NMT 6.0/7.0;
BD g/ml: 0.22 to 0.34;
+60 #, %: NMT 1
+200 #, %: NMT 30
Contact us for more information at&nb... -
Product SORBITOL 70% SOLUTION
Sorbitol 70% (D-Glucitol) SolutionGulshan Polyols, is one of the largest manufacturers of Sorbitol (D-Glucitol) with a capacity of 72000 MTPA in India. GPL's Sorbitol 70% (D-Glucitol) solution facility is an ISO 9001:2008, HACCP, OU-Kosher, HALAL & FSSAI certified company. It also meets&... -
Product DiCOM - DC
DiCOM - DC - For small dose API and large dose API with good compressibility DiCOM - DC PL - For small dose API and large dose API with good compressibility
DiCOM - DC DT - For low disintegration time formulations
DiCOM - DC SP - For li... -
Product OMYAPHARM 500-OG
OMYAPHARM 500-OG is a multifunctional mineral excipient. It is functionalized Calcium carbonate. -
Product Pharmaceutical Excipients
Biesterfeld Spezialchemie GmbH offers a wide range of pharmaceutical excipients for solid, semi-solid and liquid dosage forms. For example starch, sweeteners, sucrose, silicone fluids, macrogol, lactose, carmellose sodium, biogums, zinc oxide, propanediol, stearates etc.
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Product CROSPOVIDONE TYPE A & CROSPOVIDONE TYPE B
Crospovidone is a white to creamy-white, finely divided, free flowing, practically tasteless, odourless or nearly odorless, hygroscopic powder. -
Product Fumed Silica
Product description.
EMRASIL200 is a medium surface Fumed Silica, Synthetic,hydrophilic, amorphous silica,also named as Colloidal SiliconDioxide. Produced via flame hydrolysis.
Special features
White colloidal powder of high purity.
Tasteless, colorless, odorless;... -
Product GRANFILLER-D™
GRANFILLER-D™
-- Well-balanced tablet property between OD time and hardness
-- High API loading capacity
-- Excellent content uniformity
-- Compatible with various excipients
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Product Sheffield Pharmaceutical Grade Lactose
Kerry has over 85 years experience as a leading global manufacturer of excipients. We manufacture an extensive line of anhydrous, spray dried and monohydrate grades of lactose meeting NF/JP/EP monographs in a variety of particle sizes -
Product Microcrystalline cellulose CEOLUS™ KG
CEOLUS™ KG Grades is highly compactible MCC with fibrous particles. Enable poorly compactible and/or high dose formulations. Solve tableting issue such as insufficient hardness, sticking or capping. Also enable unique and patient friendly dosage form like MUPS, ODT, multiple-layers, multiple APIs combinati... -
Product ASHACEL ETHYLCELLULOSE
ASHACEL ETHYLCELLULOSE EXCIPIENT USED FOR CONTROLLED RELEASE, MOISTURE BARRIER AND TASTE MASKING PURPOSES IN PHARMACEUTICALS. ASHA ALSO OFFERS TECHNICAL SUPPORT TO ITS CLIENTS WHEN IT COMES TO USE OF ITS PRODUCTS IN THEIR FORMULATIONS. -
Product Trehalose SG
Trehalose is a dihydrous and non-reducing disaccharide consisting of two glucose molecules linked by an a, a-1, 1 bond. Our TREHALOSE SG is monographed as being low endotoxin and intended mainly for injection. Its remarkable stability makes this sugar an ideal excipient as a stabilizer ... -
Product Chenodeoxycholic Acid Sodium Salt
ICE S.p.A provides a wide range of products which includes chenodeoxycholic acid sodium salt. It has been the same pharmacological properties of chenodeoxycholic acid. It reduces cholesterol amount, probably by inhibiting liver synthesis, allowing gallstones dissolution. Packaging: lab or pilot scale scale... -
Product Acetic Acid, Glacial (99.9%)Ph.Eur./USP/JP parenteral grade
Aug. Hedinger GmbH & Co. KG offers a wide range of products which includes acetic acid, glacial (99.9%)parenteral grade from the producer Wacker. Contact us for more information.
Available sample CofA, Specification, MSDS, Productflyer etc.
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Product Excipients
We pride ourselves on a customer-centric approach, realizing that each customer has unique needs requiring customized solutions. Our team of dedicated Industry, Product and Technical Specialists have the experience and knowledge to help you develop solutions and reduce your costs of operation... -
Product Acrycoat® Methacrylic Acid Copolymer
Acrycoat® family of polymers are Methacrylic acid copolymers type A, B & C which confirms to USP/NF, EP and JP specification.
Immediate Release: The Immediate release series work in wide application range which includes tablet binding, taste masking, odor masking and provi... -
Product HiCel™ SMCC - Overspeed on your Tablet Press
HiCel™ SMCC is an innovative combination of MicrocrystallineCellulose Ph.Eur., USP-NF,JP, and Colloidal Silicon Dioxide Ph.Eur., USP-NF, JP by co-processed technology. This Co-processing technology leads to the formation of co-processed excipient with superior physical properties compared to simple physica... -
Product HiTech Talc IP / BP / USP / EP
Talc Powder as Excipient for use in Pharmaceutical Tablets and Pre-Mixes. -
Product YTZ Grinding media
Grinding Media for wet milling process , compatible with pharmaceutical applications for API particle size reduction to nano scale. YTZ® is recognized by users as the best available product for grinding process, providing highest quality results for employed processes. Complete traceability from... -
Product Calcium Carbonate
CFL-Chemische Fabrik Lehrte GmbH provides wide range of products which includes calcium carbonate light and heavy. Contact us for more information. -
Product Excipients
Carbomers, Castor Oil Derivates, Acrylate Copolymer, Calcium Carbonate, Carboxymethylcelullose, Crosspovidone, Calcium Phosphate, Ethylcellulose, Hydroxypropylmethylcellulose HPMC, Lactose Monohydrate, Magnesium Stearate, Maltose, Microcrystalline... -
Product Hydroxypropylcellulose
IMCD N.V. Offers a wide range of excipients which includes hydroxypropylcellulose. Contact us for more information. -
Product Glycine
This amico acid can be used as a starting material, feed additive, food additive, cosmetical ingredient, excipient or API.
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Product 5 - fluorouracil injection usp
Flagship Biotech International Pvt. Ltd offers wide range of oncology products which includes 5 - fluorouracil injection usp. Contact us for more information. -
Product Calpol
Ethypharm offers pharmaceutical products which includes calpol. Contact us for more information. -
Product Amlodipine besylate Film-coated tablet
HEC Pharm Group provides wide range of products which includes amlodipine besylate film-coated tablet. It belongs to formulation category. Contact us for more information. -
Product Espheres CACO3
Ideal cures has a wide range of products which includes espheres CACO3.It consist of CaCO3 and also used for the controlled release and MUPS formulations in nutraceutical and pharmaceutical medicine.It contains not more than 90% of calcium carbonate, calculated on the dried basis. It is adapted for control... -
Product 2-FDC HR 150/300
Chongqing Huapont Pharmaceutical Co., Ltd provides wide range of formulations which includes 2-fdc hr 150/300. Packaging: 15 pills×4 plates. Contact us for more information. -
Product Acebrofylline
Theon Pharmaceuticals Ltd. offers wide range of pharmaceutical products which includes acebrofylline. Contact us for more information. -
Product Moxdectin
Nexatis Inc offers wide range of products which includes Moxdectin. Contact us for more information. -
Product EMCOCEL®
Microcrystalline cellulose (MCC) is an odorless, tasteless, porous white powder derived from pharmaceutical grade wood pulp. With a wide range of chemical, technical, and economic benefits, MCC is one of the most widely used binder excipients for tablet formulations.
Benefits:
qq... -
Product Arginine
Shenzhen China Resources Gosun manufactures & market cephalosporin products which includes Arginine. It belongs to formulation products category. Contact us for more information. -
Product Excipients
Citric Acid AnhydrousTrisodium Citrate Anhydrous
Trisodium Citrate Dihydrate
Glucono-delta-Lactone
Sodium Gluconate
Calcium Lactate Gluconate
Monosodium Citrate
Potassium Gluconate
Tricalcium Citrate
Trimagnesium Citrate
Tripotassium Citrate
Zinc Citrate
CITROFOL® AI C... -
Product ETHOCELâ„¢ Premium Ethylcellulose Resins
An excellent choice for modified release
ETHOCELâ„¢ premium ethylcellulose resins are water-insoluble polymers. They are soluble in a wide range of organic solvents, beginning with aliphatic alcohols such as ethanol and isopropanol, and are compatible with most other familiar organic solvent chemi... -
Product METHOCELâ„¢ Cellulose Ethers
Well-recognized product that can do it allMETHOCELâ„¢ cellulose ethers are water-soluble polymers derived from cellulose. The METHOCELâ„¢ product range encompasses methylcellulose and hydroxypropyl methylcellulose (hypromellose) “ each available in different grades to address a wide range of applications i... -
Product Edetate Disodium USP (VERSENE™ NA)
VERSENE™NA Chelating Agent is an effective stabilizer and preservative for pharmaceutical preparations, including medicated creams and ointments, ocular care, syrups and elixirs. This Edetate Disodium USP-grade product controls metal ions present in pharmaceutical formulations or processes. Product B... -
Product UNI-PURE® FL
Native Starch, Corn
Low Moisture Filler
USP/NF, Ph. Eur. , JPE
NMT: 2% Moisture
*NMT: Not more than -
Product Liquid Solutions
Chemical solutions (GMP-compliant): • API & excipients • Hazardous materials • Explosives • Filling under inert gas
Special extracts and tinctures: • Mother tinctures • Boswellia extract • Opium tincture • Capsicum extract • Henbane extract • Cannabis extract
Packaging • 2... -
Product Semi-Solid Solutions
We produce ointments, creams, emulsions, pastes, and gels (including basic components) through our systems. This encompasses both semi-finished and final products, including pharmaceuticals. The manufacturing process, whether automated or semi-automated, depends on the order volume. Hänseler Swiss Phar... -
Product Solid Solutions
We specialize in the manufacturing of bulk powder mixtures in compliance with GMP standards, offered as premixtures, active pharmaceutical ingredients (APIs), or finished pharmaceutical products.
Manufacturing
Powder mixtures (premixtures o... -
Product UNI-PURE® WG 220
Fully Pregel Starch, Corn
Binder for Direct Compression
USP/NF, Ph. Eur.,Ch.P -
Product Lactalpha 100
Lactalpha 100 is a 100 Mesh pharmaceutical grade milled lactose conforming with the lactose monohydrate monograph of the current Pharmacopoeias (Ph. Eur., USP-NF and JP). The flowability of Lactalpha 100 makes it efficient as a diluent in capsule or sachet formulation.
Manufactured in Retie... -
Product Lactalpha 150
Lactalpha 150 is a 150 Mesh pharmaceutical grade milled lactose conforming with the lactose monohydrate monograph of the current Pharmacopoeias (Ph. Eur., USP-NF and JP). Lactalpha 150’s fine mesh enables it to be used as a binder or diluent for tableting after dry or wet granulation, along with guara... -
Product Commercial Support
Selectchemie AG provides a wide range of services including commercial support. Our experienced professionals are at your service at locations in 18 countries to deliver tailor-made solutions according to your needs. Contact us for more information. -
Product Health, Safety and Environment Services
Our experienced HSE experts offer various health, safety and environment services: Safety data sheet (SDS) support (SDS classification, labelling) in most EU languages, including online access and QR links; Controlled substances, precursors, highly active substances and other restricted chemicals (in-clud... -
Product Excipients
We offer a broad portfolio of excipients, covering all dosage forms including tablet, capsule, syrup, oral dispersible tablet, sachet, gel and suppository.
Our team of experts with commercial, technical and scientific backgrounds is at your service at locations in 18 countries. With our... -
Product Supply Chain Services
With a dedicated team of experienced supply chain specialists, we go far beyond conventional offerings to provide you with innovative and efficient supply chain solutions. With three strategically placed warehouses in Switzerland and Germany, we are able to store and distribute your products in a ... -
Product Simaline™ Wo
SIMALINE™ WO is an excellent water-in-oil emulsifier and effectively stabilizes all types of oils at low concentrations with textures ranging from lotions to thick creams.
• SIMALINE™ WO is compatible with a wide range of oils • It can be used to formulate water-rich W/O emulsions, with ... -
Product Simulsol™ Pha
SIMULSOL™ PHA products are hydrophilic non-ionic surfactants used as solubilizing or emulsifying agents in oral or topical formulations.
This surfactant range includes: ethoxylated fatty acids, castor oils and fatty alcohols
All the products in the SIMULSOL™ PHA range comply with the ... -
Product Amonyl™
The AMONYL™ product range is composed of betaine derivatives used for their foaming and cleansing properties.AMONYL™ products are amphoteric surfactants and can therefore be combined with other cationic, anionic or non-ionic agents under certain conditions.https://www.seppic.com/en/amonyl-range
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Product Montane™
MONTANE™ range is comprised of different sorbitan ester grades that can be used to formulate water-in-oil emulsions for oral, topical and injectable formulations.
• MONTANE™20 PHA PREMIUM: Sorbitan laurate • MONTANE™60 PHA PREMIUM: Sorbitan stearate • MONTANE™80 PHA PREMIUM: Sorbitan oleate ... -
Product Aqualon ethylcellulose
Aqualon™ ethylcellulose (EC) is a cellulose ether distinguished by its versatility. Aqualon™ EC is soluble in a wide range of organic solvents and is typically used as a non-swellable, insoluble component in matrix or coating systems. Aqualon™ EC can be used to coat one or more active ingredients of a... -
Product Aqualon CMC BET sodium carboxymethylcellulose
aqualon™ CMC BET sodium carboxymethylcellulose are viscosity modifiers for diluents and excellent suspending agents, easily dispersible in water, and compatible with most active ingredients. To learn more visit https://www.ashland.com/industries/pharmaceutical/parenteral-dosage/aqualon-cmc-ph-bet -
Product Aquarius film coating systems
aquarius™ line of fully formulated coating solutions are practical, efficient, and elegant and they provide effective, high-quality coatings that offer an optimum balance of film strength and adhesion, even for challenging cores and release profiles. The line includes titanium dioxide free option... -
Product Benecel hypromellose
Benecel™ products are high purity, water-souble, nonionic cellulose ethers. Benecel™ hypromellose (hydroxypropyl-methylcellulose or HPMC) is a versatile excipient with a variety of applications. HPMC is the most widely used polymer in hydrophilic matrix systems with widespread use in controlled... -
Product Blanose sodium carboxymethylcellulose
Blanose™ CMC are anionic, water-soluble cellulose ethers, produced by reacting alkalicellulose with monochloroacetic acid under controlled conditions. Blanose™ CMC is available in a variety of grades with different degrees of substitution,viscosity and particle size to meet specific formulation requirement... -
Product Cavamax* native cyclodextrins
The molecular structure of cyclodextrins creates a bucket-like cavity that can complex with molecules or functional groups on molecules to improve solubility of poorly soluble compounds. The same mechanism makes these excipients capable of masking unpleasant taste/odor and stabilizing drugs that are prone ... -
Product Cavitron cyclodextrins (hydroxypropyl betacyclodextrin)
cavitron™ cyclodextrins (hydroxypropyl betacyclodextrin) are the perfect substances for increasing solubility and enhancing bioavailability. They are manufactured to high purity standards for low bioburden and endotoxin.
To learn more visit https://www.ashland.com/industries/pharmaceutical/oral-... -
Product Ferronyl iron supplement
Ferronyl™ iron supplement isan ideal source of essentially pure iron with low toxicity,minimal metallic taste andexcellent bioavailability. Ferronyl™ iron supplement is elemental iron (Fe) with high (> 98%) iron content,manufactured by the chemical decomposition of iron pentacarbonyl. The resulting iron... -
Product Klucel hydroxypropylcellulose
Klucel™ hydroxypropylcellulose (HPC) is a nonionic water-soluble cellulose ether with a remarkable combination of properties. It combines organic solvent solubility, thermoplasticity and surface activity with the aqueous thickening and stabilizing properties characteristic of other water-soluble cellulose ... -
Product Natrosol hydroxyethylcellulose
Natrosol™ 250 hydroxyethylcellulose (HEC) is a nonionic, water-soluble cellulose ether. Natrosol™ 250 HEC is easily dispersed in cold or hot water to give solutions of varying viscosities and desired properties, though it is insoluble in organic solvents. It is used in solutions and gels to control rheolog... -
Product Pharmasolve N-methyl-2-pyrrolidone
Pharmasolve™ N-methyl-2-pyrrolidone (NMP) is a versatile solubilizer for one-component systems. It is a water-miscible polar aprotic solvent with high interfacial activity. Pharmasolve™ NMP is manufactured in a facility with ISO 9001:2015 and EXCiPACT GMP certifications. It is used as a drug solubilizer an... -
Product Plasdone povidone
Plasdone™ povidones are a family of water-soluble polymers based on N-vinylpyrrolidone that combine a unique set of properties for application in a wide variety of dosage forms. Plasdone™ povidones are commonly used as binders for the development of tablet formulations, whether manufactured by wet granulat... -
Product Plasdone S-630 copovidone
Plasdone™ S-630 copovidone is a 60:40 random, linear copolymer produced by the free radical polymerization of N-vinyl-2-pyrollidone and vinyl acetate. The pyrrolidone ring is responsible for excellent water solubility, adhesion, film forming and solubilization properties, while the vinyl acetate monom... -
Product Polyplasdone crospovidone
Polyplasdone™ crospovidone superdisintegrants are synthetic, insoluble, but rapidly swellable, crosslinked homopolymers of N-vinyl-2-pyrrolidone. Crospovidone provides rapid disintegration and dissolution to oral solid dosage forms. Polyplasdone crospovidone particles are granular and porous compared ... -
Product viatel bioresorbable polymers
viatel™ bioresorbable polymers control release over time. These polymers are the building blocks for developing long-acting injectable depots, an established technology to improve therapeutic efficacy and improve patient compliance. Viatel polymers are typically formulated into microspheres, solid impl... -
Product Benecel XRF HPMC
Benecel™ hypromellose (hydroxypropyl-methylcellulose or HPMC) is a versatile excipient with a variety of applications. HPMC is the most widely used polymer in hydrophilic matrix systems with widespread use in controlled-release dosage forms.
benecel™ XRF HPMC is the latest addition to the Benecel™ famil... -
Product vialose trehalose dihydrate
vialose™ trehalose dihydrate is a premier performance sugar that is resistant to acid hydrolysis and enzymatic cleavage. It is used to protect and shield biologic APIs, recombinant proteins, and monoclonal antibodies (mAbs) from degradation and aggregation and to stabilize and protect valuable componen... -
Product Klucel™ xtend hydroxypropylcellulose
Klucel™ Xtend HPC extended release matrix former is the new product in the Klucel™ line, offering unsurpassed process versatility and release profile efficiency. This step change product has been shown to match the release profile of widely used hypromellose controlled-release formulations with half the po... -
Product Klucel™ xtend hydroxypropylcellulose
Klucel™ Xtend HPC extended release matrix former is the new product in the Klucel™ line, offering unsurpassed process versatility and release profile efficiency. This step change product has been shown to match the release profile of widely used hypromellose controlled-release formulations with half the po... -
Product Polyplasdone™ plus multifunctional disintegrant
Polyplasdone™ Plus multifunctional disintegrant is a direct compression superdisintegrant containing silica and lubricant. This highly effective new product provides enhanced flow properties, self-lubrication, and enhanced tablet performance, improving overall manufacturing through-put time. Polyplasdone™ ... -
Product UNI-PURE® F
Native Starch, Corn
Extra-White Filler
USP/NF, Ph. Eur., JPE
NMT: 15% Moisture
*NMT: Not more than -
Product UNI-PURE® GA P100
Modified Corn Starch
Gelatin replacement for Veggie Softgels
USP/NF, Ph. Eur.
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Product Povidon Iodine Solution
Unilab chemicals and pharmaceuticals pvt. Ltd offers a wide range of products which includes povidon iodine soln. Application: povidon iodine soln. 5% w/v for topical use. Active ingredient: povidon iodine ip/usp 5% w/v. Contact us for more information. -
Product Povidon Iodine Scrub
Unilab chemicals and pharmaceuticals pvt. Ltd offers a wide range of products which includes povidon iodine scrub. Application: povidon iodine cleansing soln. Active ingredient: povidon iodine ip/usp 10%, 7.5% & 5% w/v respectively. Contact us for more information. -
Product Lysol
Unilab chemicals and pharmaceuticals pvt. Ltd offers a wide range of products which includes lysol. Application: cresol with soap soln. Active ingredient: cresol 50% v/v soap 50% v/v. Contact us for more information. -
Product Benzalkonium Chloride Solution
Unilab chemicals and pharmaceuticals pvt. Ltd offers a wide range of products which includes benzalkonium chloride solution. Application: it is equivalent to benzalkonium chloride (as preservative - 0.01%, aqueous base – q.s.). The nebracin dm drops and ointment are widely used for steroid responsive infla... -
Product Strong Cetrimide Solution BP/EP
Strong Cetrimide Solution available with Ethanol, Iso Propanol WHO GMP, US FDA approved facility DMF, CEP, COPP, WC available -
Product Maize starch/corn starch
Anhui Sunhere Pharmaceutical Excipients offers wide range of pharmaceutical products which includes maize starch/corn starch. Packaging: 25kg/kraft bag; 25kg/fiber drum. Main purpose: tablet and capsule diluent;tablet and capsule disintegrant;. Contact us for more information. -
Product Mineral Gluconates
Dr. Paul Lohmann® offers various highly bioavailable Mineral Gluconates with API documentation - ASMFs and for Ferrous Gluconate a CEP - for the registration of a drug with the health authorities. Please contact us for more information.
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Product Ferric Polymaltose Complex
Dr. Paul Lohmann® offers Ferric Polymaltose Complex with API documentation. Through protection of the iron core by maltose molecules, gastrointestinal side effects are prevented which makes Ferric Polymaltose an ideal API for treatment of iron deficiency anemia and hyperphosphatemia. Please contact us ... -
Product Macrogol 4000 / Hedjuvan-MG4000
Hedjuvan-MG4000 is a high quality Macrogol 4000. The product is produced at Kolb in Hedingen and is tested according to the specification of the current Ph. Eur. and USP.The physical form of the products is "pastilles".
Kolb has a broad portfolio of non-ionic surfactants with polysorbates ... -
Product Polysorbate 20 / Hedjuvan-PS20
Hedjuvan-PS20 is a high quality Polysorbate 20. The product is produced at Kolb in Hedingen (Switzerland) and is getting tested according to the specifications of the Ph. Eur., USP. and ChP. Furthermore the product meets the specification for the USP monograph as injectable grade. Kolb has a broad p... -
Product Polysorbate 80 / Hedjuvan-PS80
Hedjuvan-PS80 is a high quality Polysorbate 80. The product is produced at Kolb in Hedingen (Switzerland) and is getting tested according to the specifications of the Ph. Eur., USP, JP and ChP. Kolb has a broad portfolio of non-ionic surfactants with polysorbates having a long successfull track recor... -
Product Sodium Hyaluronate - Medical grade
Hyature® is a pharmaceutical grade sodium hyaluronate which can be used as an API or excipient for drugs and medical devices in ophthalmic preparations, intra-articular injections, anti-adhesive preparations, topical preparations for wound healing and soft tissue filler, etc. Hyature® sodium hyalur... -
Product Ectoine (Bloomecto™) - medical device grade
Ectoine-MD (trade name:Bloomecto™) is a highly pure Ectoine developed by Bloomage professional fermentation platform technology, with high stability and safety profile. As a compatible solute within extremophiles survived under extreme conditions, ectoine can protect cells from external agents such as alle... -
Product Calcium Phosphate Excipients
Innophos manufactures an extensive portfolio of calcium phosphate excipients and co-processed excipients. Our products are supported by technical experts to assist our customers solve their pharmaceutical, dietary supplement and food product formulation challenges. Our co-processed A-Tab® M... -
Product Nutra-Tab®
Nutra-Tab® is a co-processed multifunctional excipient that enhances compressibility in nutraceutical tablets. Using Nutra-Tab® will improve tablet hardness, increase manufacturing efficiency, create a smaller tablet size, and simply your formulations by significantly reducing the number of ingredients... -
Product Tri-Tab® PVP
Tri-Tab® PVP is a co-processed multifunctional excipient (Tricalcium Phosphate and Povidone) that enhances compressibility in pharmaceutical tablets. Tri-Tab® PVP improves tablet integrity and hardness, increases manufacturing efficiency, and results in a smaller tablet size while being a source of cal... -
Product Purified Talc IP BP USP
Marked at the best rate possible, the offered Purified Talc IP BP USP manufactured and supplied by us, has a high preference in the market. For the purpose of quality maintenance, the offered range is processed as per the set industry norms and guidelines, utilizing the finest ingredients and machines... -
Product Analytical Services
Actylis performs routine and non-routine analytical testing for various industries, in support of manufacturing processes, QA/QC functions, R&D projects, and environmental applications. Leveraging state-of-the-art instrumentation, extensive knowledge base, as well as internal, cross-functional competen... -
Product AnyCoat-P® (Hypromellose phthalate); HPMCP; Hydroxypropylmethylcellulose phthalate
AnyCoat-P® is a beloved brand name of the cellulose ether manufactured by LOTTE Fine Chemical.
Properties: white or yellowish white powder; soluble in mixed organic or aqueous solvent; making up transparent film when solvent remove.
Applications: Pharmaceutical excipient, ... -
Product Sucrose (Low endotoxin 0.2EU/g)
This is high quality Sucrose with low endotoxin (0.2EU/g) originally from Hokkaido Japan. The specification criteria meets Japanese Pharmacopeia that can safely use in Pharma industry. -
Product Sunvidone ® VA/Copovidone VA series
Huzhou sunflower pharmacetuical co. Ltd offers a wide range of products which includes copovidone va series. Feature:
it is low water and alcohol solution viscosity of the product, and the viscosity coefficient is small; under normal conditions stable, but in strong acid or alkali solution an... -
Product Sunvidone ® CL/Crospovidone Type A and Type B
CRACTERISTICSSUNVIDONE CL series are supplied as fine white or almost white powders. They have a slight characteristic odour and are practically tasteless. They are insoluble in all the usual solvents.
APPLIICATIONS
SUNVIDONE CL series possess a number of useful properties for pharmaceutical products... -
Product Povidone K series
Povidone K series have been widely applied in medicine and is one of the three new pharmaceutical excipients advocated internationally, among which the most widely used as adhesives for tablets and granules. PVP can also be utilized as flow aid for capsules, detoxifying agent and lubricant for op... -
Product Crospovidone /PVPP
Crospovidone xl is a kind of thermosetting plastic with a network structure. It has outstanding abrasion resistance, solvent resistance, dimensional stability, stress crack resistance, anti-aging and weather resistance, non-toxic, odorless, and non-absorbent. Good low temperature flexibility, excellent hea... -
Product Povidone Iodine/ PVP-I
PVP-I is a complex of PVP and iodine, which has a strong killing effect on bacteria, viruses, fungi, molds and spores. Stable, non-irritating, completely water soluble.It is widely used in hospital surgery, injection and other skin disinfection and instrument disinfection, oral, gynecology, surgery, dermat... -
Product EXCIPRESS™ SD2L
EXCIPRESS™ SD2L is a Spray-Dried lactose typically used for Direct Compression.
Spray-Dried lactose consists of fine primary lactose particles bound in a matrix of amorphous lactose. Its spherical shape enables the highest flowability.
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Product PYROSTAR™ Neo
PYROSTAR™ Neo is a new endotoxin detection reagent developed by recombinant technology.
PYROSTAR Neo is a lyophilized reagent that combines 3 recombinant factors (factor C, factor B, proclotting enzyme) with sequences derived from Limulus polyphemus and a chromogenic substrate (peptidyl pNA).The... -
Product CertiPro Series
CertiPro Series are product series of pharmaceutical raw material that complies with GMP with process validation. Process validation secures quality stability from batch to batch, and our well organised quality assurance team maintains high reliability in the market.
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Product Microcrystalline Cellulose/MCC
Main purpose: The product of partial hydrolysis of natural cellulose by dilute acid is a kind of short rod shaped or powder shaped porous fine particles with fluidity, white or nearly white in color, odorless and tasteless.In the pharmaceutical industry, MCC is commonly used as an adsorbent, suspension aid... -
Product Hypromellose/Hydroxypropyl Methyl Cellulose/HPMC
It is mainly used as film forming agent for film coating, emulsifier for gel and ointment, suspending agent and stabilizer. -
Product LIGAMED CPR-2-V-MB
Some pharmaceutical formulations include vegetable based Calcium Stearate instead of Magnesium Stearate. Our LIGAMED CPR-2-V-MB is a perfect choice encompassing all core LIGAMED® pharmaceutical excipient principles. LIGAMED CPR-2-V is also used as a water repellent agent in the production of effervescent t... -
Product LIGAMED MF-2-V-BI-MB
LIGAMED MF-2-K-BI-MB is the RSPO Mass Balance certified alternative product for LIGAMED MF-2-V-BI. It offers the same positive properties as the standards product but is produced with RSPO Mass Balance certified fatty acid. -
Product PALMSTAR AL PHARMA-MB
PALMSTAR AL PHARMA-MB is one of our Aluminium Stearates with the best gelling performance capabilities. It is very suitable as an emulsion stabilizer and viscosity increasing agent for creams and ointments. Additionally, pharmaceutical applications use it as an anti-caking agent or suspending agent. PALMST... -
Product Excipient: Super Refined™ PEG 400
Super Refined PEGs are solvents for use with the most sensitive active ingredients across dosage forms including injectable and oral. Super Refining removes polar impurities (including primary and secondary oxidation products) from an excipient without altering its chemical composition, reducing excipi... -
Product Excipient: Super Refined™ Polysorbate 20
Super Refined Polysorbates solubilise and stabilise the most sensitive active ingredients across dosage forms including injectable and oral. Super Refining removes impurities (including primary and secondary oxidation products) from an excipient without altering its chemical composition, helping to red...
Excipients
From coating and binding agents to ointment bases, antioxidants and more, search a wide range of excipients from hundreds of international suppliers online at CPhI Online.
The word excipient, derived from the Latin phrase excipere - to receive, to except, or take out, refers to any component other than the active pharmaceutical ingredient contained in solid dosage forms or used to manufacture a finished pharmaceutical product (FPP). Excipients play a significant role in the formulation and administration of dosage forms and the drug development process. They affect the aesthetics, processing capability, bioavailability, and performance of the drug substance and the compliance of patients using a specific dosage form.
Excipients can either act as carriers (basis or vehicles) or diluents, etc., of the active ingredients or components. They aid in the drug product manufacturing process and also enhance the bioavailability, stability, appearance, storage integrity, effectiveness, safety, and delivery of the drug product during use.
Excipients and active ingredients form the major components of drugs. However, excipients make up the bulk of drugs and medicines, making about 90% of each drug’s composition. These substances are mostly pharmacologically inactive or inert and serve specific purposes. However, as opposed to popular assumptions, excipients are not always inactive or inert and may result in side effects or adverse reactions if misused.
The wrong choice, quality, combination, or amounts of excipients used can have devastating effects on the patient’s health. Like every other drug component, these inactive ingredients need to be standardized, regulated, and validated to ensure the safety of the chemical decomposition products for consumption.
Pharmaceutical products contain not just active ingredients but also other components that largely influence the drug’s pharmacokinetics and pharmacodynamics.
There are a variety of excipients contained in FPP dosage form. The type of excipient included in each FPP is determined by the active ingredient contained, route of administration, and intended dosage form. For example, a tablet formulation is an oral dosage form and usually contains binders, fillers, diluents, disintegrators, and lubricants.
How many excipients are used in the pharmaceutical industry?
In almost every drug form, there is an excipient or combination of excipients and there are over 1,000 excipients used to manufacture finished pharmaceutical products.
Initially, excipients consisted of biologically inert, structurally simple, and naturally derived substances such as minerals, wheat, sugar, etc. Nevertheless, in recent times, the production of novel drug formation systems has led to several new and novel excipients such as coprocessed excipients.
How are pharmaceutical excipients classified?
Excipients are classified based on their route of administration (oral, parenteral, and topical excipients, etc.), on origin (Organic and inorganic chemicals), and by functionality (Fillers, emulsifying agents, excipients for direct compression, etc.). These classifications have subdivisions.
The oral dosage forms make up most dosage forms administered to patients due to their formulation, ease of formulation, administration, and transport, among many others. Given this, the main excipients are found in solid dosage formulations and serve as high revenue drivers in the pharmaceutical excipient market. Some main excipients include calcium phosphate, dicalcium phosphate, starch, magnesium stearate, gelatin, and several others.
Role of excipients in drug formation
The traditional use of excipients has been modified by the development of novel drug delivery systems. Beyond increasing the bulk of formulation and simplifying the manufacturing process, excipients perform a variety of roles such as binding ingredients, boosting patient’s acceptance and compliance (by masking unpleasant odors or tastes), enhancing the stability of active ingredients, extending viability and acting as diluents (for example, microcrystalline cellulose, starch), etc.
How do excipients affect the performance of drug products?
The bioavailability of drugs refers to the amount of and rate at which a drug’s active ingredient is being made available at its active site. Although excipients are generally pharmacologically inert or inactive, they can interact with drugs in various dosage forms and influence physiologic factors during absorption, distribution, and elimination.
Excipients that affect the bioavailability of drug formulations are capable of influencing their overall performance, either in a positive way by improving performance and therapeutic effect, or in a negative way by diminishing them. The extent of the impact is dependent on the dose and potency of the formulation, site of absorption, therapeutic window, or rate-limiting factors of drug absorption, and many other factors.
Excipients can result in pharmacokinetic interactions through modulation of intercellular tight junctions, metabolic enzymes, and transporter proteins. The bioavailability of drugs can be affected by excipients’ solubility at absorption sites, liability to enzymatic interaction and degradation, drug-excipient interactions, etc.
Poorly water-soluble drug formulations will result in low and erratic bioavailability. However, lipid-based, surfactant-based, and polymeric excipients have high solubility rates and can improve bioavailability.
Ionizable and soluble excipients can exhibit charge interactions with APIs. For example, positively charged drugs such as polymycin and neomycin can form precipitations in the presence of sodium alginate.
Excipients can also affect the dissolution kinetics of drugs by altering the medium in which the drug dissolves or reacting with the drug. Suspending agents help increase the viscosity of the drug vehicle, which, in turn, reduces the dissolution rate from suspensions. For example, an excessive amount of magnesium stearate in tablet formulations can repel water, and limit the rate of drug dissolution, thereby decreasing the rate of drug absorption and the bioavailability of the drug. Formulation processes such as wet granulation, also have a huge effect on the bioavailability of drugs.
Best practices in dealing with novel excipients
Novel excipients are simply excipients used in drug formulations or through a route of administration for the first time. These excipients could be new chemical products or a previously used and certified excipient that hasn’t been established for use by humans or through a specific administration route.
For example, new solubilizers are required to solve the drug delivery challenges associated with poorly water-soluble drugs. New and novel excipients usually include natural polymer excipients, synthetic polymers, natural polymers modified with/by synthetic polymers, coprocessed excipients, and synthetic polymers modified by other combinations or smaller molecules. Some examples of novel excipients include albumin, Soluplus, Kollicoat Smartseal 3D, etc.
Novel excipients play an essential role in producing and introducing new, advanced, and safer drugs to the pharmaceutical market. However, due to global regulatory policies, there have been various challenges to the development of new excipients. Regardless of this, more companies are adopting innovative excipients to develop novel drug formulations. This has given way for more recent and advanced drug delivery systems to provide safer and more effective drugs for patients and more convenient administration routes. The concept of novel excipients has further broadened the scope of pharmaceutical science.
What drug development challenges do drug sponsors encounter during the manufacturing process that could be addressed by using novel excipients?
With new and significant innovations in the pharmaceutical industry, such as the development of novel drugs for the treatment of rare and orphan diseases, the need for new and advanced excipients to boost drug delivery systems is on the rise. As drug products evolve and increase in structural complexity, the formulation challenges also increase. The use of novel excipients significantly impacts the drug development process, creating various treatment types available to patients, and introducing new therapies into the pharma market.
The development and evaluation of NCEs are costly to process compared to the process of modification of previously established excipients. This issue can be addressed by the development of multi-functional novel excipients, which can perform several roles such as boosting drug stability and bioavailability, controlling API release based on therapeutic needs, etc. These excipients’ production results in a significant decrease in manufacturing cost, hastens the drug development process and improves drug sales and company growth.
Other challenges encountered by sponsors include the need for solubility, stability and permeability modulation, loss of compaction due to wet granulations and high-moisture compatibility of drugs, and increased demands for ideal filler-binders for direct compression, among others.
What are the latest guidelines for novel excipients?
Currently, novel excipients are not evaluated and regulated independently. However, they can be submitted, evaluated, and regulated as part of an IND or IMPD. There are no clear-cut or approved regulatory pathways provided by the FDA or the European Medicines Agency (EMA) to independently assess the efficacy and safety of novel excipients. This present a major barrier and set-back to the pharmaceutical excipient industry and global market, limiting innovation of new and novel excipients regardless of whether they are modifications of existing chemical entities or new chemical entities (NCE).
Although the International Pharmaceutical Excipients Council has been advocating since 2011 for the implementation of a novel excipient approval process by the FDA, the evaluation process hasn’t been put in place. Implementing a novel excipient review or evaluation program will significantly drive the pharmaceutical industry and give room for innovative drug formulations.
Top trends in pharmaceutical excipients
The pharmaceutical excipient industry is rapidly evolving and is continuously searching for new ways to provide innovative and advanced drug formulations for therapeutic purposes. According to a recent study, the global pharmaceutical excipient market is anticipated to experience massive growth over the 2019-2025 forecast period. The market size is expected to reach an estimated value of USD 9.7 billion, at a steady CAGR of 5.8%.
The pharmaceutical excipient markets’ top trends include the increased use of nanotechnology, patent expiries, increased demand for multi-functional excipients, a competitive market landscape, the binders segment taking the lead as the fastest-growing market, and North America possessing the largest share in the global market. The pace of the global pharmaceutical excipient market growth serves as a pharma trend barometer.
Who are the top players in the pharmaceutical excipients industry?
Due to the increasing need for pharmaceutical excipients and the exponential growth of the global pharmaceutical excipient market, there has been a rising competition between excipient manufacturer and excipient supplier in this industry. Amongst the competitor is top players that have largely contributed to the growth of the pharmaceutical excipient industry.
Some of the top players in the pharmaceutical excipient industry include BASF SE, Evonik Industries AG, Lubrizol Corporation, Croda International Plc., Ashland Inc., Avantor Performance Materials Inc., The Dow Chemical Company, Innophos Holdings Inc., Archer Daniels Midland Company, Colorcon Inc., Kerry Group, Merck, Signet, and FMC Corporation amongst many others. The collaborative efforts, expansions, and agreements of these excipient manufacturers to boost the growth of the market.
What is the revenue, sales, and price analysis of top manufacturers of pharmaceutical excipients?
The binder’s segment is anticipated to dominate the pharmaceutical excipient market during the forecast period. In 2017, the pharmaceutical excipients market achieved a total revenue of about USD 4256.3 million, and this revenue is anticipated to grow at a rate of about 6% until 2023. The growing income levels, increasing health expenditures, and improved health awareness globally reflect the many potentials of pharmaceutical excipients.
In addition, the organic segment of the excipient market, including carbohydrates, proteins, petrochemicals, and others, is likely to contribute to the growth of the pharmaceutical excipients market. The rising demand for and application of organic excipients in pharmaceutical industries is expected to drive sales and market growth. Given this, the organic chemicals market share segment is anticipated to grow faster than the inorganic market segment. This benefits the manufacturers and the patients alike.
It is expected that top pharmaceutical excipients manufacturers in North America will record a spike in revenue generation during the forecast period. It would be influenced by the development of advanced infrastructures as well as better investment policies. Several pharmaceutical excipient manufacturing companies in this region participate in projects contributing to the growing demand for novel and advanced drugs.
In addition to this, the massive investments being made are also significant contributors to the anticipated revenue generation. Companies in Europe are also expected to partake in the revenue generation. Also, the Asia Pacific region is expected to experience an increase in revenue generation through structural investments.
Prices of manufactured excipients across various regions globally are dependent on the excipient supply and excipient demand chain within each region. Also, this is dependent on the quality of excipients being produced in each of these regions.
What key factors drive the global pharmaceutical excipients market?
The pharmaceutical drug market size is growing rapidly, and its growth is expected to drive positively impact the growth and size of the pharmaceutical excipient market. In addition to this, several other key factors have driven and are still driving the pharmaceutical excipient market’s growth. Some of these factors include advancement in functional excipient development, increased use and expansion of biopharmaceuticals, large patient population base, the prevalence of chronic diseases, the rapid growth of the biosimilar industry, increasing demand for generic drug, patent expiries, and development of multi-functional and co processed excipient. These key factors have primarily contributed to the growth of the pharmaceutical excipient market during the forecast period.
Excipients play a variety of roles in drug formulations and make up the bulk of almost every drug. The pharmaceutical industry is rapidly advancing through biotechnology to provide safer and more effective drugs for therapeutic purposes. Novel excipients are gaining worldwide attention, and the push for a novel excipient review and evaluation system is growing stronger. In a few years from now, there may be the creation of an established novel excipients evaluation process or system. The establishment of these evaluation processes would allow companies to grow, deliver on-demand health needs to patients, and spur the global pharmaceutical excipients market’s growth.
References
https://www.pharmaexcipients.com/pharmaceutical-excipients-some-definition/
https://www.biopharma-excellence.com/news/2019/12/13/best-practices-in-dealing-with-novel-excipients
https://www.pharmaexcipients.com/wp-content/uploads/attachments/CO5_2013_RGB_80-83.pdf?t=1446883266
https://www.slideshare.net/mobile/SalmanBaig6/novel-excipients
https://www.pharmaexcipients.com/news
References
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28th March 2024
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4pm CET / 10am EST
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Webinar Achieving Manufacturing Excellence Through Digital Transformation
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16th April 2024
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4pm CET / 10am EST
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Webinar Case Study: Risk Management for Annex 1 Sterile Production EMS
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28th February 2024
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4pm CET / 10am EST
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Webinar Innovative Strategies for B2B Pharma Marketeers: Driving Value through Content
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20th February 2024
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4pm CET / 10am EST
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Webinar Revolutionizing Pharma: Data and AI Unleashed
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18th January 2024
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4pm CET / 10am EST
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Webinar Optimal Temperature: Elevating Biologics Cold Chain Excellence
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16th January 2024
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4pm CET / 10am EST
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Webinar Market Outlook – The Biggest Pharma Trends of 2024
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12th December 2023
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4pm CET / 10am EST
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Webinar The Next Frontier – Emerging Opportunities in the LATAM Pharma Market
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21st November 2023
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4pm CET / 10am EST
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Webinar Vistamaxx™ MED - imagine the possibilities for healthcare product performance
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10th October, 2023
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4pm CET / 10am EST
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Webinar Co-processing: A Multifaceted Approach for Enhancing Density & Powder Flow
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19th September 2023
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4pm CET / 10am EST
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Webinar The Outlook for Cell & Gene Therapy Manufacturing
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28th June 2023
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4pm CET / 10am EST
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Webinar Contract Packaging Outlook: Growth Trends within the Commercial Packaging Sector
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25th May 2023
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4pm CET / 10am EST
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Webinar The HPAPI Boom: How Pharma is Rising to the Manufacturing Challenge
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23rd February 2023
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4pm CET / 10am EST
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Webinar Optimal Capsule Selection for your Pharma and Nutra Products
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15th February 2023
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4pm CET / 10am EST
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Position your company at the heart of the global Pharma industry with a CPHI Online membership
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Your products and solutions visible to thousands of visitors within the largest Pharma marketplace
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Generate high-quality, engaged leads for your business, all year round
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Promote your business as the industry’s thought-leader by hosting your reports, brochures and videos within your profile
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Your company’s profile boosted at all participating CPHI events
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An easy-to-use platform with a detailed dashboard showing your leads and performance