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Excipients
Excipients Companies (148)
Excipients News
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News Roquette expands plant-based excipient portfolio with Crest Cellulose acquisition
Crest Cellulose, an Indian excipient manufacturer, has been acquired by plant-based pharmaceutical excipient provider Roquette in a bid to increase the latter’s presence in the Asia Pacific region.4 Oct 2022 -
News Dr. Paul Lohmann® - Your Partner for high value Mineral Salts
With our expertise in the chemical and physical modification of Minerals and our customer-oriented philosophy, we are the ideal partner to turn your ideas into reality. Meet us at CPHI stand #110F50!27 Sep 2022 -
News Accepting novel excipients for innovative drug development
With the rapid development and manufacturing of new drugs and therapeutics being pushed through the pipeline, excipient manufacturers are navigating a challenging landscape to meet the demand for new and novel excipients.30 Aug 2022 -
News CPHI Podcast Series: The importance of novel excipients for innovative drug development
The latest episode in the CPHI Podcast Series dives into the world of novel excipients and explores their importance for innovative drug development.2 Aug 2022 -
News Hovione and Zerion Pharma collaborate to commercialise low drug solubility solution
By joining forces, the two companies will be able to bring Dispersome to the market faster for novel drug development22 Feb 2022 -
Sponsored Content Croda: Solutions for Your High Value Drug Products
Formulating a drug for parenteral delivery comes with its fair set of challenges. Aside from a high level of sensitivity to external factors like light and heat exposure, these large and complex drugs are prone to degradation when exposed to various ch...11 Feb 2022 -
News UPDATED: COVID-19 Pharma Development Tracker
The latest coronavirus updates and developments impacting the global pharmaceutical supply chain23 Mar 2023 -
News Roquette to advance drug delivery research with new US Innovation Center
The new facility will focus on the research of excipients for oral dosage forms, drug delivery systems, nutraceutical APIs and innovative pharma ingredients14 Dec 2021 -
News CPHI releases Pharma Trends 2022 report
CPHI has launched its forward-looking pharma trend report for 2022 and it is now available to read on CPHI Online.6 Dec 2021 -
News CPHI Podcast Series: Annual Report 2021 Roundtable
In this special edition podcast, Informa Markets pharma editor Gareth Carpenter speaks to Bikash Chatterjee, CEO at Pharmatech Associates and Dan Stanton, Editor and Founder at BioProcess International about some of the findings in the recently pu...23 Nov 2021 -
News CPHI Worldwide is back, and this time it’s hybrid
A new in-person and online edition of CPHI Worldwide, transforming your event experience.1 Nov 2021 -
Sponsored Content CPHI Webinar: Develop ODTs in a FLASH with UltraBurst™ - Watch On Demand
Catch up on the latest trends and developments in orally disintegrating tablet (ODT) formulation development30 Sep 2021 -
Sponsored Content IFF Pharma Solutions: Paving the Way for Superior Suspensions
Shawn Branning, Global Strategic Marketing Manager at IFF – Pharma Solutions30 Sep 2021 -
News The Top Ten CPHI Discover Company Showcases
CPHI Discover (May 17-28) gave Pharma companies, suppliers and service providers the opportunity to keep potential buyers and partners abreast of the latest news, product information and market trends in the form of free-to-access, downloadable content...3 Jun 2021 -
News COVID-19 Pharma Development Tracker
The latest coronavirus updates and developments impacting the global pharmaceutical supply chain (continued from here)31 May 2021 -
News APIs, excipients and formulation: the bedrock of medical innovation
Our virtual CPHI Discover event (17th-28th May) is just around the corner, full to the brim with three main content tracks. Here, we explore the major trends in APIs, Ingredients & Formulation12 May 2021 -
News CPHI Discover: Earlier partnerships between pharma and excipient manufacturers are the key to success
In the future pharma companies will need to work closer with excipient companies if we are to develop better formulations more quickly6 May 2021 -
News CPHI Discover: Remote excipient audits are on the increase, but we must do more to develop novel excipients
Ahead of the session, Value Added Excipients to Unlock the Potential of APIs, at CPHI Discover on Thursday 18th May – global pharma’s largest ever virtual gathering – we spoke with one of the speakers, Dr Iain Moor...4 May 2021 -
News Excipients – an industry adapting to change
Excipients are a crucial component of the pharmaceutical product formulation, and the industry is constantly having to adapt to changes in demand and technology innovations15 Mar 2021 -
News Top 5 Industry Content Reads on CPHI Online This Month
If you’re looking for news, product information and market trends from leading pharma companies, the CPHI-Online.com Company Showcases are a great resource for buyers who want to stay up to date, browse product portfolios and find the right partn...18 Jan 2021
Excipients Products (500+)
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Product 2,6-Dimethyl-β-Cyclodextrin
VIO Chemicals offers a broad range of excipients for drug formulation, including 2,6-Dimethyl-β-Cyclodextrin to enhance the solubility of the drug. CAS No 51166-71-3 -
Product Biologic Drug Substance & Drug Product Formulation
To date, KBI has conducted over 130 successful protein, peptide, and vaccine formulation development programs. KBI’s approach to formulation development is based on the strategic pairing of two complementary scientific disciplines:
Establishing a comprehensive understanding of the thermal, physical, che... -
Product Sodium stearyl fumarate, micronized (EP, USP/NF, JP)
VIO Chemicals can offer micronized Sodium stearyl fumarate with controlled D50 particle sizes of 10 μm and below. Technical profile: • Technical name: Sodium stearyl fumarate • CAS No: 4070-80-8 • Emprirical formula: C22H39NaO4 • Molecular weight: 390.53 Advantages: Sodium steary... -
Product ETHOCELâ„¢ Premium Ethylcellulose Resins
An excellent choice for modified release
ETHOCELâ„¢ premium ethylcellulose resins are water-insoluble polymers. They are soluble in a wide range of organic solvents, beginning with aliphatic alcohols such as ethanol and isopropanol, and are compatible with most other familiar organic solvent chemi... -
Product METHOCELâ„¢ Cellulose Ethers
Well-recognized product that can do it allMETHOCELâ„¢ cellulose ethers are water-soluble polymers derived from cellulose. The METHOCELâ„¢ product range encompasses methylcellulose and hydroxypropyl methylcellulose (hypromellose) “ each available in different grades to address a wide range of applications i... -
Product CARBOWAX™ SENTRY™ Polyethylene Glycol (PEG)
CARBOWAX™ SENTRY™ PEGs common applications include: carrier/plasticizer in gel capsules, base for face/neck lotions, providing formulation stability in toothpaste, binder for tablets, shampoo wetting agent, and more. CARBOWAX™ SENTRY™ PEGs are available in average molecular weights ranging from 3... -
Product Edetate Disodium USP (VERSENE™ NA)
VERSENE™NA Chelating Agent is an effective stabilizer and preservative for pharmaceutical preparations, including medicated creams and ointments, ocular care, syrups and elixirs. This Edetate Disodium USP-grade product controls metal ions present in pharmaceutical formulations or processes. Product B... -
Product Excipient: Super Refined™ DEGEE
Super Refined DEGEE is ideal for use in topical and transdermal applications to enhance the permeation of poorly water-soluble API’s through various layers of the skin, thereby improving drug delivery. It can also be used as a co-solvent in self-emulsifying drug delivery systems (SEDDS), or self-microe... -
Product Excipients
Actylis, through its recent acquisitions, has become a leading global GMP excipients manufacturer to the life sciences industry, offering our customers a broad portfolio of excipients. Our excipients are currently employed in vaccines, injectables, dermal, transdermal, topical and solid dosage finishe... -
Product Neohesperdin DC Pharma Grade
FDA approved
Excipient to improve the bitter aftertaste of medicines. Very powerful masking agent.
Dosage to adjust case-by-case. Search optimal dosage with our Laboratory.
Leading Production plant with proprietary technology & environmental re... -
Product Polyglykol
Effective and high-purity ingredients including a complete range of Polyglykols (Macrogols) our universally applicable pharmaceutical polymers, with various molecular weights, supported by CEP certification and DMF type II documentation. -
Product MANNITAB™ SD Line
Mannitol powder
Binder for direct compression
USP/NF, Ph. Eur., BP, IP
Particle size: 100 µ and 180 µ
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Product Virus Inactivated Plasma
Both in industry and in research, human plasma is used as a supplement to cell culture media and as a component of bioassays, immunoassays or enzyme assays.
Replacing the commonly used fetal calf serum (FCS) with human plasma, in combination with platelet lysate, supports the growth and proliferatio... -
Product Lactohale® 200
Lactohale® 200 is milled lactose produced with a tightly controlled mean particle size. The size of the particles of Lactohale® 200 can be controlled and but also varied by gentle milling. This means that different D50's can be produced depending on the degree of milling to match the cust... -
Product Functional ingredients
Bioavailability enhancers
Our drug facilitators target and enhance bioavailability to help support the activity of your active ingredients.
Antioxidants
Our antioxidants can be used to improve the stability of your pharmaceutical formulation. In addition, due to their role in suppressi... -
Product SNAC CAS 203787-91-1
CAS:203787-91-1
Molecular Weight:301.31337
Molecular Formula: C15H20NNaO4
Appearance: white powder
Application: medical intermediate
Delivery Time: Available goods in stock
Package: inside: douple PE bag outside: paper drum
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Product Macrogol 400 / Hedjuvan-MG400
Hedjuvan-MG400 is a high quality Macrogol 400. The product is produced at Kolb in Hedingen (Switzerland) and is getting tested according to the specifications of the current Ph. Eur. and USP. Kolb has a broad portfolio of non-ionic surfactants with polysorbates having a long successfull trac... -
Product SUNETT® Sweeteners
Sunett® Brand Acesulfame-K manufactured in Germany is a zero calorie, great tasting sweetener that has excellent purity, stability and solubility making it an ideal sweetener for many different applications. Sunett® is also available in pharmaceutical grades in order to provide drug manufacturers all ... -
Product Ascorbic acid
Fine Foods & Pharmaceuticals N.T.M. Spa offers wide range of API which includes ascorbic acid. Contact us for more information. -
Product Excipients
Carbomers, Castor Oil Derivates, Acrylate Copolymer, Calcium Carbonate, Carboxymethylcelullose, Crosspovidone, Calcium Phosphate, Ethylcellulose, Hydroxypropylmethylcellulose HPMC, Lactose Monohydrate, Magnesium Stearate, Maltose, Microcrystalline... -
Product Excipients - Pharmaceutical Ingredients
To ensure our customers are up to the task of meeting the pharmaceutical industry’s high expectations when it comes to “the formulation of pharmaceuticals”, Smart Ingredients offers a comprehensive line-up of excipients and services and a dedicated team that fulfilling almost manufacturers’ needs. Our tech... -
Product Excipients
We pride ourselves on a customer-centric approach, realizing that each customer has unique needs requiring customized solutions. Our team of dedicated Industry, Product and Technical Specialists have the experience and knowledge to help you develop solutions and reduce your costs of operation... -
Product Expansorb
Poly(lactic acid co-glycolic acid) and poly(caprolactone) copolymers used as functional excipients for controlled and slow drug release (weeks to months) with a single injection. -
Product CROSCARMELLOSE SODIUM
odium croscarmellose is an internally cross-linked sodium carboxymethylcellulose for use as a superdisintegrant in pharmaceutical formulations. -
Product LIGAMED MF-2-V-MB
LIGAMED MF-2-V-MB is our most widely used excipient for the production of tablets and capsules. Its high specific surface area and fine particles offer a high releasing speed during tablet pressing and consistent physical performance of the tablets such as hardness and dissolution profiles. Due to the exce... -
Product Lactose Product Portfolio
MEGGLE has it: The Right Lactose Product for all Needs
The world of lactose is our whole world. With this in mind, our products are aligned specifically to your needs and applications. For further information on any product shown here, please see the detailed, individual product brochure ava... -
Product APISAL (Sodium chloride API)
For the exceptionally high requirements in pharmaceutical manufacturing processes, we produce pure pharmaceutical salt exceeding the purity requirements stipulated in the pharmacopoeias. All steps of production, analysis, and quality control comply with these strict principles. APISAL® is obtained from a p... -
Product DRCOAT - Customised Ready to use Coating Pharma Polymer
ENTERIC COATING (AQUEOUS / NON AQUEOUS)IMMIDIATE RELEASE FILM COATING / FILM COATING
MOISTUER BARRIER COATING
PEARSCENT COATING / METTALIC COATING
GLOW COATING / GLOSS COATING
TRANSPARENT COATING
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Product Octanoic Acid (BP, Ph. Eur., USP-NF) pure, pharma grade code BH2786
https://www.itwreagents.com/iberia/en/product/octanoic-acid-bp-ph-eur-usp-nf-pure-pharma-grade/BH2786 -
Product PEARLITOL® - Mannitol
PEARLITOL® Mannitol pharma range is used as a filler and filler/binder as well as a bulk sweetener. The PEARLITOL® range offers a unique blend of exceptional physical and chemical stability and no hygroscopicity.PEARLITOL® can be used in various oral dosage forms in both pharmaceutical and nutraceutic... -
Product Stearic Acid
Stellipress Brand ensures EP/USP compliance of our high purity Micronized Stearic Acid.
Our Stearic Acid is your best choice as a Tablet Lubricant and Magnesium Stearate replacement.
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Product Embo caps®
Suheung capsules offers a wide range of products which includes embo caps. It belongs to empty hard capsules category.
By embossing four dimples on the main locking groove of the cap, the exclusive EMBO CAPS® is designed to offer distinct advantages.
To eliminate premature semi-locking and final... -
Product Sunvidone ®K/Povidone K series
Huzhou sunflower pharmacetuical co. Ltd offers a wide range of products which includes povidone K series. Feature: it is an aqueous solution of synthetic polymer compound is n vinyl pyrrolidone polymers are linear. It is white to milky white amorphous powder, having a bulk density of 0.4 to 0.6; odor... -
Product Carbopol excipients
Products within the Carbopol® polymer family are chemically similar in that they are all high molecular weight, crosslinked polyacrylic acid polymers. They can be used in a variety of dosage forms, including oral, mucosal, topical, ophthalmic, etc.
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Product Emulfree Duo
Emulfree® Duo is a ready-to-use system. It has been designed to stabilize the oil phase within a bi-gel, an emerging topical formulation, by ensuring fine and homogeneous dispersion in the aqueous phase. As a PEG-free excipient, it is ideal for sensitive skins and mucosea.
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Product EUDRAGIT® Functional Polymers
Evonik is a global development partner and solutions provider for oral drug delivery. For more than 60 years, we have been providing renowned pharmaceutical and biotech companies with oral drug delivery solutions to help them enhance drug performance, reduce project complexity, increase speed to market and... -
Product Excipia Experts in excipient analysis, characterization and deformulation / reverse engineering
Excipients can have an important impact on the manufacturability and pharmaceutical performance of a formulation. It’s therefore important to identify and control functionality related characteristics (FRCs) of excipient materials in order to achieve safe, robust and stable products. Expe... -
Product BAC
Benzalkonium Chloride Ph.Eur., USP/NF (BKC/BAC/BAK) CAS No. 8001-54-5
Consists of Benzyl (dodecyl) dimethyl ammonium chloride (C12 approx. 65%) and Benzyl (tetradecyl) dimethyl ammonium chloride (C14 approx. 35%). Other chain length distributions are also available. Available with more ... -
Product A-Tab® MD
A-Tab® MD is a multi-functional co-processed excipient specially formulated to enhance compressibility and simplify formulations in pharmaceutical and nutraceutical tablets. -
Product Manufacturing
Custom API Manufacturing, Fermentation, Finished Dosage Form, High Potency, Lipid Nanoparticle, Rare / Orphan, Stability & Release Testing, Sterile Fill Finish, APIs & Intermediates, Fine Chemicals
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Product Excipress™ GR150
EXCIPRESS™ GR150 is a granulated lactose typically used for Direct Compression. -
Product Hydroxypropylcellulose low-substitued (L-HPC)
Your benefits
- wide range of types to cover various applications and technologies
- produced according to IPEC-GMP guidelines
- Chinese DMF available
- increase the stability of your API in the finished dosage form and enables formulation of smaller table... -
Product TABLUBE - MAGNESIUM STEARATE
Nitika Pharmaceutical Specialities Pvt Ltd provides wide range of excipients which includes Tablube - Magnesium Stearate. It's a type of lubricants and glidants.
Product Description:
· DMF Available
· &nbs... -
Product Montanox™
The MONTANOX™ range is composed of different grades of polysorbates that can be used to solubilize active pharmaceutical and/or biological ingredients and to formulate oil-in-water emulsions for oral, topical and injectable products.
• MONTANOX™20 PHA PREMIUM: Polysorbate 20 • MONTANOX™60 PHA PREMIU... -
Product galenIQ 720
BENEO-Palatinit GmbH provides the pharmaceutical excipient galenIQ™ 720. It is an agglomerated spherical isomalt for direct compression and powder applications. General benefits: high agglomerate stability and excellent flow; morphology ensures homogeneity of the mix and content uniformity; very low compre... -
Product Calcium Carbonate IP
We are considered in the market to be one of the leading manufacturers and suppliers of this commendable Calcium Carbonate IP BP USP EP JP and OYSTER. Processing of this product is done in accordance with the set norms and guidelines of the chemical industry, utilizing the finest ingredients and ... -
Product Dexolve
Dexolve is the first generic USP and EP-conform Betadex Sulfobutyl Ether Sodium for:• solubility enhancement (10 to 100,000 fold) • Improvement of chemical stability • Increased bioavailability, facilitated delivery • Reduced aggregation • Moderate irritationor reduced side-effects • Maximiz... -
Product Polyglykol
Polyethylene glycols or PEGs as Active Pharmaceutical Ingredients and Excipients used in a variety of pharmaceutical applications. -
Product Sheffield Pharmaceutical Grade Lactose
Kerry has over 85 years experience as a leading global manufacturer of excipients. We manufacture an extensive line of anhydrous, spray dried and monohydrate grades of lactose meeting NF/JP/EP monographs in a variety of particle sizes -
Product ASHACEL ETHYLCELLULOSE
ASHACEL ETHYLCELLULOSE EXCIPIENT USED FOR CONTROLLED RELEASE, MOISTURE BARRIER AND TASTE MASKING PURPOSES IN PHARMACEUTICALS. ASHA ALSO OFFERS TECHNICAL SUPPORT TO ITS CLIENTS WHEN IT COMES TO USE OF ITS PRODUCTS IN THEIR FORMULATIONS. -
Product Trehalose SG
Trehalose is a dihydrous and non-reducing disaccharide consisting of two glucose molecules linked by an a, a-1, 1 bond. Our TREHALOSE SG is monographed as being low endotoxin and intended mainly for injection. Its remarkable stability makes this sugar an ideal excipient as a stabilizer ... -
Product Chenodeoxycholic Acid Sodium Salt
ICE S.p.A provides a wide range of products which includes chenodeoxycholic acid sodium salt. It has been the same pharmacological properties of chenodeoxycholic acid. It reduces cholesterol amount, probably by inhibiting liver synthesis, allowing gallstones dissolution. Packaging: lab or pilot scale scale... -
Product Disodium Hydrogen Phosphate 2-hydrate
Dr. Paul Lohmann® offers a wide range of high-quality Mineral Salts suitable for the final vaccine formulation. Since Mineral Salts stabilize biologics and vaccines during processing, storage and application, they are an essential part of the entire biomanufacturing process. Please contact us for ... -
Product Sodium Hyaluronate - Injection grade
Hyature® is a pharmaceutical grade sodium hyaluronate which can be used as an API or excipient for drugs and medical devices in ophthalmic preparations, intra-articular injections, anti-adhesive preparations, topical preparations for wound healing and soft tissue filler, etc. Hyature® sodium hyalur... -
Product Specialized Parenteral Drug Services
Meeting the parenteral drug delivery challenge with Evonik. Polymer-based parenteral formulations taking extended release and targeted release further – advanced parenterals from small molecules to biopharmaceuticals - all bases covered. Lipid nanoparticle drug delivery technologies for oligon... -
Product Acetic Acid, Glacial (99.9%)Ph.Eur./USP/JP parenteral grade
Aug. Hedinger GmbH & Co. KG offers a wide range of products which includes acetic acid, glacial (99.9%)parenteral grade from the producer Wacker. Contact us for more information.
Available sample CofA, Specification, MSDS, Productflyer etc.
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Product Acrycoat® Methacrylic Acid Copolymer
Acrycoat® family of polymers are Methacrylic acid copolymers type A, B & C which confirms to USP/NF, EP and JP specification.
Immediate Release: The Immediate release series work in wide application range which includes tablet binding, taste masking, odor masking and provi... -
Product HiCel™ SMCC - Overspeed on your Tablet Press
HiCel™ SMCC is an innovative combination of MicrocrystallineCellulose Ph.Eur., USP-NF,JP, and Colloidal Silicon Dioxide Ph.Eur., USP-NF, JP by co-processed technology. This Co-processing technology leads to the formation of co-processed excipient with superior physical properties compared to simple physica... -
Product YTZ Grinding media
Grinding Media for wet milling process , compatible with pharmaceutical applications for API particle size reduction to nano scale. YTZ® is recognized by users as the best available product for grinding process, providing highest quality results for employed processes. Complete traceability from... -
Product Calcium Carbonate
CFL-Chemische Fabrik Lehrte GmbH provides wide range of products which includes calcium carbonate light and heavy. Contact us for more information. -
Product Calcium phosphate (anhydrous and dihydrate)
IMCD N.V. Offers a wide range of excipients which includes calcium phosphate (anhydrous and dihydrate). Contact us for more information. -
Product Hydroxypropyl Cellulose
Nisso Chemical Europe GmbH offers a wide range of products which includes hydroxypropyl cellulose. It is mainly used in solution form. As a binder for wet granulation applications, low viscosity grades of hpc give an excellent balance of properties to oral solid dosage tablets by imparting superior strengt... -
Product Glycine
This amico acid can be used as a starting material, feed additive, food additive, cosmetical ingredient, excipient or API.
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Product Captisol
Captisol® is a patent protected, uniquely modified cyclodextrin, whose chemical structure was rationally designed to enable the creation of new products by significantly improving solubility, stability, bioavailability and dosing of active pharmaceutical ingredients (APIs).
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Product Corbrin capsule
Hangzhou Zhongmei Huadong Pharmaceutical provides wide range of pharmaceutical products which includes corbrin capsule. It belongs to formulation category. Functions: nourishes lung and kidney and benefits vital essence. Its effective for the treatment of cough, asthma, chronic kidney trouble, chroni... -
Product Analytical research and developement (ar&d)
Aizant drug research solutions pvt ltd is an integrated drug development solutions provider which includes analytical research and developement (ar&d). It belongs to dosage from development category. It includes microbial limit test, antimicrobial efficacy test, environmental monitoring, water chemical and... -
Product Antara
Ethypharm offers pharmaceutical products which includes antara. Contact us for more information. -
Product Amlodipine besylate Film-coated tablet
HEC Pharm Group provides wide range of products which includes amlodipine besylate film-coated tablet. It belongs to formulation category. Contact us for more information. -
Product Apocanda ® cream
Aristo pharma gmbh offers a wide range of products which includes apocanda ® cream. It belongs to antiinfectives category. Features: broad spectrum of active agents to treat fungal infections of the skin, the feet and hands, good compatibility, inexpensive alternative.. Contact us for more information. -
Product Espheres CACO3
Ideal cures has a wide range of products which includes espheres CACO3.It consist of CaCO3 and also used for the controlled release and MUPS formulations in nutraceutical and pharmaceutical medicine.It contains not more than 90% of calcium carbonate, calculated on the dried basis. It is adapted for control... -
Product Crospovidone
Anhui Sunhere Pharmaceutical Excipients offers wide range of pharmaceutical products which includes crospovidone. Packaging: 20kg/fiber drum. Main purpose: tablets, granules, pills, disintegrants and fillers. Contact us for more information. -
Product 2-FDC HR 150/300
Chongqing Huapont Pharmaceutical Co., Ltd provides wide range of formulations which includes 2-fdc hr 150/300. Packaging: 15 pills×4 plates. Contact us for more information. -
Product Moxdectin
Nexatis Inc offers wide range of products which includes Moxdectin. Contact us for more information. -
Product EMCOCEL®
Microcrystalline cellulose (MCC) is an odorless, tasteless, porous white powder derived from pharmaceutical grade wood pulp. With a wide range of chemical, technical, and economic benefits, MCC is one of the most widely used binder excipients for tablet formulations.
Benefits:
qq... -
Product Arginine
Shenzhen China Resources Gosun manufactures & market cephalosporin products which includes Arginine. It belongs to formulation products category. Contact us for more information. -
Product Low endotoxin Trehalose (EP, USP/NF, JP)
VIO Chemicals offers high quality low endotoxin and GMO-free Trehalose dihydrate and Trehalose anhydrous, for pharmaceutical and cosmetic applications, in a very competitive price. Technical profile: • Technical name: α, α-D-Trehalose dihydrate • CAS No: 6138-23-4 • Empirical for... -
Product Sodium glycocholate
VIO Chemicals offers Sodium glycocholate as advanced bile acid component for robust drug formulation and delivery. Technical profile: • Technical name: Sodium glycocholate • CAS No: 863-57-0 • Empirical formula: C26H42NNaO6 • Molecular weight: 487.60 Advantag... -
Product Glycocholic acid
VIO Chemicals offers Glycocholic acid as advanced bile acid component for robust drug formulation and delivery. Technical profile: • Technical name: Glycocholic acid • CAS No: 475-31-0 • Empirical formula: C26H43NO6 • Molecular weight: 465.62 Advantages: ... -
Product D-Galactose, plant derived
VIO Chemicals offers a broad range of low endotoxin carbohydrates, including D-Galactose, plant derived for biopharmaceutical applications. CAS No: 59-23-4, -
Product D-Mannose, plant derived (EP, USP/NF)
VIO Chemicals offers a range of low endotoxin carbohydrates, including D-Mannose, plant derived, for biopharmaceutical applications. CAS No: 3458-28-4 -
Product Hydroxypropyl-β-Cyclodextrin (EP, USP/NF)
VIO Chemicals offers a broad range of excipients for drug formulation, including Hydroxypropyl-β-Cyclodextrin to enhance the solubility of the drug. CAS No: 128446-35-5 -
Product Sulfobutylether-β-Cyclodextrin (EP, USP/NF)
VIO Chemicals offers a broad range of excipients for drug formulation, including Sulfobutylether-β-Cyclodextrin to enhance the solubility of the drug. CAS No: 182410-00-0 -
Product Low endotoxin Sucrose (EP, USP/NF, JP)
VIO Chemicals offers a broad range of low endotoxin carbohydrates, including Sucrose. CAS No: 57-50-1 -
Product Low endotoxin D-Maltose monohydrate (USP/NF)
VIO Chemicals offers low endotoxin carbohydrates, including D-Maltose monohydrate to use as excipient. CAS No: 6363-53-7 -
Product Hydroxypropyl-γ-Cyclodextrin (HP-γ-CD)
ADVANTAGES
Cyclodextrins (CDs) are oligosaccharides used as complexing agents to increase the water solubility of lipophilic compounds and bio-availability of medicinal products.
Due to their cyclic structure, cyclodextrins can form inclusion complexes when they interact with hydropho... -
Product 2,5-Dimethyl isosorbide
Dimethyl Isosorbide is a little helper ingredient used in various personal care applications to enhance the delivery of active ingredients, providing good skin penetration power and boosting performance. -
Product METHOCEL™ Cellulose Ethers
Well-recognized product that can do it all
METHOCEL™ cellulose ethers are water-soluble polymers derived from cellulose. The METHOCEL™ product range encompasses methylcellulose and hydroxypropyl methylcellulose (hypromellose) – each available in different grades to address a wide range of applic... -
Product Avicel® Microcrystalline Cellulose (MCC)
The renowned binder for tablets
Avicel® microcrystalline cellulose (MCC) is a purified, partially depolymerized alphacellulose excipient made by acid hydrolysis of specialty wood pulp.
For nearly 60 years, Avicel® has exceeded the performance of common pill binders by pushing the ... -
Product ETHOCEL™ Premium Ethylcellulose Resins
An excellent choice for modified release
ETHOCEL™ premium ethylcellulose resins are water-insoluble polymers. They are soluble in a wide range of organic solvents, beginning with aliphatic alcohols such as ethanol and isopropanol, and are compatible with most other familiar organic solvent chemi... -
Product Alginates: Protanal®, Manucol®, Protacid® and More
Unique functionality for a broad range of pharmaceutical applications
Alginates are natural hydrocolloids extracted from sustainably harvested seaweed. Chemically, alginates are formed from polysaccharides with building blocks comprised of salts of mannuronic and guluronic acid. Th... -
Product GRINDSTED® Xanthan Gum
GRINDSTED® Xanthan Gum is a naturally fermented product of carbohydrates and is applied in various liquid, semi-solid and solid pharmaceutical dosage forms.
Application in pharmaceutical formulations
GRINDSTED® Xanthan Gum readily dissolves in water under ambient conditions without ... -
Product TEXTURECEL™
Ingenious ingredient for many pharmaceutical applications
TEXTURECEL™ is highly purified sodium carboxymethyl cellulose (NaCMC) that forms clear solutions in water at all temperatures, has exceptional water binding properties, and is available in a wide range of viscosity grades.
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Product Excipient: Super Refined™ P35 Caster Oil
Super Refined P35 Castor Oil is a castor oil derivative, resulting from the reaction of glycerol ricinoleate and 35 mols of ethylene oxide. This product is a liquid nonionic solubiliser and emulsifier, characteristic of a slightly yellow hue, and is intended for use in parenteral, ophthalmic, oral, and... -
Product Excipient: Super Refined™ PEG 400
Super Refined PEGs are solvents for use with the most sensitive active ingredients across dosage forms including injectable and oral. Super Refining removes polar impurities (including primary and secondary oxidation products) from an excipient without altering its chemical composition, reducing excipi... -
Product Excipient: Super Refined™ Polysorbate 20
Super Refined Polysorbates solubilise and stabilise the most sensitive active ingredients across dosage forms including injectable and oral. Super Refining removes impurities (including primary and secondary oxidation products) from an excipient without altering its chemical composition, helping to red... -
Product Excipient: Super Refined™ Polysorbate 80
Super Refined Polysorbates solubilise and stabilise the most sensitive active ingredients across dosage forms including injectable and oral. Super Refining removes impurities (including primary and secondary oxidation products) from an excipient without altering its chemical composition, helping to red... -
Product Tween™ 80 HP
Tween™ 80 HP: • Tween™ 80 HP goes beyond standard polysorbate monograph requirements to provide a low moisture, low peroxide version of Tween 80 designed for parenteral applications and applications where API stability presents a challenge • O/W emulsifier, solubiliser and wetting agent • An additional h... -
Product MANNITAB™ F Line
Mannitol fine Powder
Filler
USP/NF, Ph. Eur. , BP, IP
Particle size: 25, 50 and 160 µ
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Product UNI-PURE® WG 220
Fully Pregel Starch, Corn
Binder for Direct Compression
USP/NF, Ph. Eur.,Ch.P -
Product UNI-PURE® F
Native Starch, Corn
Extra-White Filler
USP/NF, Ph. Eur., JPE
NMT: 15% Moisture
*NMT: Not more than -
Product FARMAL® SSG Line
Sodium Starch Glycolate
Superdisintegrant
USP/NF, Ph. Eur., BP, IP
Potato and Corn -
Product UNI-PURE® GA P100
Modified Corn Starch
Gelatin replacement for Veggie Softgels
USP/NF, Ph. Eur.
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Product UNI-PURE® FL
Native Starch, Corn
Low Moisture Filler
USP/NF, Ph. Eur. , JPE
NMT: 2% Moisture
*NMT: Not more than -
Product ALC-0159
ALC-0159 is a polyethylene glycol (PEG)-lipid conjugate also called a PEGylated lipid.
ALC-0159 is a lipid excipient that can be used to form lipid nanoparticles (LNPs). -
Product Super Refined™ GTCC
Super Refined™ GTCC:Super Refined GTCC is a high purity mixed ester consisting primarily of the saturated fatty acids caprylic (C8) and capric (C10) acid. Products of this type are commonly referred to as medium chain triglycerides (MCT) and they possess a number of useful properties in nutritional and top... -
Product viatel bioresorbable polymers
viatel™ bioresorbable polymers control release over time. These polymers are the building blocks for developing long-acting injectable depots, an established technology to improve therapeutic efficacy and improve patient compliance. Viatel polymers are typically formulated into microspheres, solid impl... -
Product vialose trehalose dihydrate
vialose™ trehalose dihydrate is a premier performance sugar that is resistant to acid hydrolysis and enzymatic cleavage. It is used to protect and shield biologic APIs, recombinant proteins, and monoclonal antibodies (mAbs) from degradation and aggregation and to stabilize and protect valuable componen... -
Product Aqualon CMC BET sodium carboxymethylcellulose
aqualon™ CMC BET sodium carboxymethylcellulose are viscosity modifiers for diluents and excellent suspending agents, easily dispersible in water, and compatible with most active ingredients. To learn more visit https://www.ashland.com/industries/pharmaceutical/parenteral-dosage/aqualon-cmc-ph-bet -
Product Cavitron cyclodextrins (hydroxypropyl betacyclodextrin)
cavitron™ cyclodextrins (hydroxypropyl betacyclodextrin) are the perfect substances for increasing solubility and enhancing bioavailability. They are manufactured to high purity standards for low bioburden and endotoxin.
To learn more visit https://www.ashland.com/industries/pharmaceutical/oral-... -
Product Contract R&D
Actylis offers GMP, biopharma and non-GMP specialty chemical custom ingredient research and development services by generating robust, practical and cost-effective processes for the preparation of specialty chemicals, excipients, and pharmaceutical ingredients. With decades of experienc... -
Product Analytical Services
Actylis performs routine and non-routine analytical testing for various industries, in support of manufacturing processes, QA/QC functions, R&D projects, and environmental applications. Leveraging state-of-the-art instrumentation, extensive knowledge base, as well as internal, cross-functional competen... -
Product benecel XRF HPMC
benecel™ XRF HPMC are fine particle grades designed for optimal performance in large-scale, high speed tableting. For more information visit https://www.ashland.com/industries/pharmaceutical/oral-solid-dose/benecelxr
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Product Aqualon ethylcellulose
Aqualon™ ethylcellulose (EC) is a cellulose ether distinguished by its versatility. Aqualon™ EC is soluble in a wide range of organic solvents and is typically used as a non-swellable, insoluble component in matrix or coating systems. Aqualon™ EC can be used to coat one or more active ingredients of a... -
Product Aquarius film coating systems
Ashland's line of fully formulated, easily dispersed and ready-to-use Aquarius™ film coating systems have a range of functions to suit almost any core. With our wide selection of film coating choices, we can provide an optimal coating for your unique formulation. Aquarius™ Preferred film coating syste... -
Product Benecel methylcellulose and hypromellose
Benecel™ products are high purity, water-souble, nonionic cellulose ethers. Benecel™ hypromellose (hydroxypropyl-methylcellulose or HPMC) is a versatile excipient with a variety of applications. HPMC is the most widely used polymer in hydrophilic matrix systems with widespread use in controlled... -
Product Blanose sodium carboxymethylcellulose
Blanose™ CMC are anionic, water-soluble cellulose ethers, produced by reacting alkalicellulose with monochloroacetic acid under controlled conditions. Blanose™ CMC is available in a variety of grades with different degrees of substitution,viscosity and particle size to meet specific formulation requirement... -
Product Cavamax* native cyclodextrins
The molecular structure of cyclodextrins creates a bucket-like cavity that can complex with molecules or functional groups on molecules to improve solubility of poorly soluble compounds. The same mechanism makes these excipients capable of masking unpleasant taste/odor and stabilizing drugs that are prone ... -
Product Ferronyl iron supplement
Ferronyl™ iron supplement isan ideal source of essentially pure iron with low toxicity,minimal metallic taste andexcellent bioavailability. Ferronyl™ iron supplement is elemental iron (Fe) with high (> 98%) iron content,manufactured by the chemical decomposition of iron pentacarbonyl. The resulting iron... -
Product Klucel hydroxypropylcellulose
Klucel™ hydroxypropylcellulose (HPC) is a nonionic water-soluble cellulose ether with a remarkable combination of properties. It combines organic solvent solubility, thermoplasticity and surface activity with the aqueous thickening and stabilizing properties characteristic of other water-soluble cellulose ... -
Product Natrosol hydroxyethylcellulose
Natrosol™ 250 hydroxyethylcellulose (HEC) is a nonionic, water-soluble cellulose ether. Natrosol™ 250 HEC is easily dispersed in cold or hot water to give solutions of varying viscosities and desired properties, though it is insoluble in organic solvents. It is used in solutions and gels to control rheolog... -
Product Pharmasolve N-methyl-2-pyrrolidone
Pharmasolve™ N-methyl-2-pyrrolidone (NMP) is a versatile solubilizer for one-component systems. It is a water-miscible polar aprotic solvent with high interfacial activity. Pharmasolve™ NMP is manufactured in a facility with ISO 9001:2015 and EXCiPACT GMP certifications. It is used as a drug solubilizer an... -
Product Plasdone povidone
Plasdone™ povidones are a family of water-soluble polymers based on N-vinylpyrrolidone that combine a unique set of properties for application in a wide variety of dosage forms. Plasdone™ povidones are commonly used as binders for the development of tablet formulations, whether manufactured by wet granulat... -
Product Plasdone S-630 copovidone
Plasdone™ S-630 copovidone is a 60:40 random, linear copolymer produced by the free radical polymerization of N-vinyl-2-pyrollidone and vinyl acetate. The pyrrolidone ring is responsible for excellent water solubility, adhesion, film forming and solubilization properties, while the vinyl acetate monom... -
Product Polyplasdone crospovidone
Polyplasdone™ crospovidone superdisintegrants are synthetic, insoluble, but rapidly swellable, crosslinked homopolymers of N-vinyl-2-pyrrolidone. Crospovidone provides rapid disintegration and dissolution to oral solid dosage forms. Polyplasdone crospovidone particles are granular and porous compared ... -
Product Human Antithrombin III Concentrate
In order to minimize thrombogenicity, antithrombin III is used as an additive in the production of protein solutions such as prothrombin complex concentrates due to its anticoagulant properties. -
Product Human Fibrinogen Concentrate
During blood coagulation, fibrinogen (coagulation factor I) is converted into fibrin by the serine protease thrombin (coagulation factor IIa). Fibrinogen has various applications in pharmaceutical and biotechnological manufacturing. It can be used as a coating on medical devices, and in wound healing. ... -
Product Immunoglobulin
Immunoglobulin is an established remedy for antibody deficiencies and several autoimmune diseases. Immunoglobulins, also known as antibodies, help the immune system fight infections and decrease inflammation in the body. -
Product Human Serum Albumin
Human Albumin is widely used as an excipient in drug formulation, as a component of cell culture media, for drug delivery, cryopreservation of cells, vaccine manufacturing, or coating of medical devices; ultimately making it a versatile agent in pharmaceutical and biotechnological products.
... -
Product Macrogol 4000 / Hedjuvan-MG4000
Hedjuvan-MG4000 is a high quality Macrogol 4000. The product is produced at Kolb in Hedingen and is tested according to the specification of the current Ph. Eur. and USP.The physical form of the products is "pastilles".
Kolb has a broad portfolio of non-ionic surfactants with polysorbates ... -
Product Macrogol Lauryl Ether 9 / Hedjuvan-PD9
Hedjuvan-PD9 is a high quality Macrogol Lauryl Ether 9. The product is produced at Kolb in Hedingen and is tested according to the specification of the current Ph. Eur.Kolb has a broad portfolio of non-ionic surfactants with polysorbates having a long successfull track record for solubilising and en... -
Product Polysorbate 20 / Hedjuvan-PS20
Hedjuvan-PS20 is a high quality Polysorbate 20. The product is produced at Kolb in Hedingen (Switzerland) and is getting tested according to the specifications of the Ph. Eur., USP. and ChP.Kolb has a broad portfolio of non-ionic surfactants with polysorbates having a long successfull track record ... -
Product Polysorbate 80 / Hedjuvan-PS80
Hedjuvan-PS80 is a high quality Polysorbate 80. The product is produced at Kolb in Hedingen (Switzerland) and is getting tested according to the specifications of the Ph. Eur., USP, JP and ChP. Kolb has a broad portfolio of non-ionic surfactants with polysorbates having a long successfull track recor... -
Product Pharmatose® 200M
DFE Pharma offers a wide range of milled and sieved products, including the Pharmatose® and LactoPress® brands. Varying degrees of particle sizes can be offered to allow pharmaceutical companies to choose the grade best fitting their formulation needs.
Products can be supplied in various offer... -
Product Pharmacel® 112
DFE Pharma has various microcrystalline cellulose offerings under the brand name Pharmacel®, including Pharmacel® 101, 102 and 112. Pharmacel® 112 is specifically designed for formulating active pharmaceutical ingredients with a high sensitivity for moisture.
Pharmacel® is supplied in 2... -
Product SuperTab® 30GR
SuperTab® 30GR is a highly consistent, agglomerated monohydrate lactose developed for an optimal flow/compaction ratio in direct compression. It is a product with ideal mixing properties for low to high dose formulations, and thereby contributes to an efficient development process.
SuperT... -
Product SuperTab® 21AN
SuperTab® 21AN is a highly consistent anhydrous lactose with excellent compaction and re-compaction. Its low moisture content makes SuperTab® 21AN a popular choice in formulating with moisture sensitive API’s. For those formulators that require additional compaction and/or flow DFE Pharma offers SuperT... -
Product SuperTab® 11SD
SuperTab® 11SD is a highly consistent, spray-dried monohydrate lactose enabling efficient tableting by offering free flow properties. It is designed to combine the high compactibility of finely milled lactose with good flow properties of spherical spray-dried particles. For those formulators that requi... -
Product SuperTab® 40LL
SuperTab® 40LL is a co-processed excipient combining anhydrous lactose with lactitol. SuperTab® 40LL combines all required functionalities into one single excipient. It redefines the limits of direct compression, making it the excipient of choice for mini-tablet and/or other challenging formulations. qq... -
Product Respitose® SV014
Respitose® SV014 is a sieved inhalation-grade lactose grade with excellent flow properties and very large lactose crystals. It’s optimal flow properties provides opportunities for application in reservoir devices or to maintain the required flow and content uniformity in high dose inhalation formulatio... -
Product BioHale® Sucrose
BioHale® Sucrose is a non-reducing crystalline disaccharide made up of glucose and fructose. Sucrose is commonly used in the biopharmaceutical industry to stabilize proteins, lipids, and carbohydrates during the formulation process. The utility and function is driven by its unique chemical and physical pro... -
Product BioHale® Trehalose Dihydrate
BioHale® Trehalose Dihydrate is a non-reducing disaccharide consisting of two glucose molecules which are linked by an α, α-1,1 bond. It is used in the pharmaceutical industry as a stabilizer of biologics.
Trehalose Dihydrate has proven to be highly effective in protecting cell membranes... -
Product Lactohale® 206
Lactohale® 206 is a milled grade of alpha-monohydrate lactose where the fine lactose particles have been removed. The mean particle size can be tightly controlled by milling to match the customer’s requirement.
Customers can further optimise their inhaled formulation for flow and depositi... -
Product Lactohale® 300
Lactohale® 300 is a very fine and micronised lactose with a D50 below 5 microns. Lactohale® 300 is applied to Dry Powder Inhalation formulation to improve the drug deposition or optimize the flow properties of their formulation. In addition, Lactohale® 300 can be blended with several coarse lactose gra... -
Product Atenolol
Fine Foods & Pharmaceuticals N.T.M. Spa offers wide range of API which includes atenolol. Contact us for more information. -
Product Buprenorfine HCl
Fine Foods & Pharmaceuticals N.T.M. Spa offers wide range of API which includes buprenorfine HCl. Contact us for more information. -
Product Calcium carbonate
Fine Foods & Pharmaceuticals N.T.M. Spa offers wide range of API which includes calcium carbonate. Contact us for more information. -
Product Chlortalidon
Fine Foods & Pharmaceuticals N.T.M. Spa offers wide range of API which includes chlortalidon. Contact us for more information. -
Product Co-Processed Excipients
Advantol (chewable tablets), Effersoda (effervescent tablets), Pharmaburst and Pharmasperse -
Product LIGAMED CPR-2-V-MB
Some pharmaceutical formulations include vegetable based Calcium Stearate instead of Magnesium Stearate. Our LIGAMED CPR-2-V-MB is a perfect choice encompassing all core LIGAMED® pharmaceutical excipient principles. LIGAMED CPR-2-V is also used as a water repellent agent in the production of effervescent t... -
Product LIGAMED MF-2-V-BI-MB
LIGAMED MF-2-K-BI-MB is the RSPO Mass Balance certified alternative product for LIGAMED MF-2-V-BI. It offers the same positive properties as the standards product but is produced with RSPO Mass Balance certified fatty acid. -
Product PALMSTAR AL PHARMA-MB
PALMSTAR AL PHARMA-MB is one of our Aluminium Stearates with the best gelling performance capabilities. It is very suitable as an emulsion stabilizer and viscosity increasing agent for creams and ointments. Additionally, pharmaceutical applications use it as an anti-caking agent or suspending agent. PALMST... -
Product APION - ION EXCHANGE CROSS LINKED POLYMER
TASTE MASKING - ION EXCHANGE POLYMER
DISINTEGRANT - POLACRILIN POTTASIUM
For More Details log on to
www.vikramthermo.com -
Product DRUGCOAT - Methacrylic acid Copolymer based Basic Pharma Polymer
DRUGCOAT L 30D / L 100-55 / L 100-55DDRUGCOAT L 100 / L 12.5
DRUGCOAT S 100 / S 12.5 / FS 30D
DRUGCOAT E 100 / E PO / E 12.5
DRUGCOAT RL 100 / RL PO/ RL 12.5
DRUGCOAT RS 100 / RS PO/ RS 12.5
DRUGCOAT NE 30D -
Product Dimethyl Sulfoxide (USP, BP, Ph. Eur.) pharma grade CODE 191954
https://www.itwreagents.com/iberia/en/product/dimethyl-sulfoxide-usp-bp-ph-eur-pharma-grade/191954 -
Product Glyceryl Dibehenate / Glyceryl Behenate
Our EP/USP/IIG listed Stelliesters DBHG, Is An Excellent Multifunctional Excipient, Lubricant, Sustained Release Agent, Taste Masking Agent And A Hotmelt Matrix.
Join Our Booth To Discuss Your Projects With Our Oral Formulation Experts.
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Product RSPO Mass Balance Excipients
Our EP/USP Ranges - STELLIESTERS, DUBCARE, STELLIPRESS, DUB PP - Are Proposed In Mass Balance RSPO Quality.
Join Our Booth To Discuss With Our Corporate Projet Manager About Your Sustainability Project Implementation And How We Could Share Experience.
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Product Medical Device Excipients
Specific Excipients of EP/USP Ranges - STELLIESTERS, DUBCARE, STELLIPRESS, DUB PP - Are adequate for your medical device projects and formulations.
Join Our Booth To Discuss With Our Regulatory and Formulation Experts About Your Medical Device Projects And How We Could Share Experience. qq... -
Product Soft Gel Excipients
Our Stelliesters Range presents the most classic and innovative Solubilizers for Soft Gel Formulations.
Join Our Booth To get a Review with our Solubiliy Experts concerning your Soft Gel Solubilizers available in our Excipients Portfolio.
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Product Embo caps® VG ALPHA
EMBO CAPS® VG ALPHA is a vegetable capsule which has been manufactured from Hypromellose(HPMC) without any gelling agent through a thermal gelatin process.
EMBO CAPS® VG ALPHA is greater in strength and glossy in appearance.
As it does not contain materials which ... -
Product Pathway™ TPU Excipients
LLS Health has been a leading supplier of medical and pharmaceutical grade polymers for more than 50 years. Our Pathway™ TPU excipients build upon this expertise, offering controlled drug release and compatibility with a wide range of active pharmaceutical ingredients (APIs). Pathway TPU is an ideal o... -
Product Apinovex™ Polymers
Lubrizol’s Apinovex™ polymers are high molecular weight polyacrylic acid excipients designed to provide both processing and formulation benefits for spray-dried amorphous solid dispersions (ASDs).
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Product EUDRATEC Fasteric
A new oral drug delivery technology providing enteric protection followed by rapid, homogeneous release for effective pH targeting of the upper small intestine where there is a narrow absorption window.
Find our presentation on the Evonik Oncare platform: https://oncare.evonik.com/media/?fil...
Excipients
From coating and binding agents to ointment bases, antioxidants and more, search a wide range of excipients from hundreds of international suppliers online at CPhI Online.
The word excipient, derived from the Latin phrase excipere - to receive, to except, or take out, refers to any component other than the active pharmaceutical ingredient contained in solid dosage forms or used to manufacture a finished pharmaceutical product (FPP). Excipients play a significant role in the formulation and administration of dosage forms and the drug development process. They affect the aesthetics, processing capability, bioavailability, and performance of the drug substance and the compliance of patients using a specific dosage form.
Excipients can either act as carriers (basis or vehicles) or diluents, etc., of the active ingredients or components. They aid in the drug product manufacturing process and also enhance the bioavailability, stability, appearance, storage integrity, effectiveness, safety, and delivery of the drug product during use.
Excipients and active ingredients form the major components of drugs. However, excipients make up the bulk of drugs and medicines, making about 90% of each drug’s composition. These substances are mostly pharmacologically inactive or inert and serve specific purposes. However, as opposed to popular assumptions, excipients are not always inactive or inert and may result in side effects or adverse reactions if misused.
The wrong choice, quality, combination, or amounts of excipients used can have devastating effects on the patient’s health. Like every other drug component, these inactive ingredients need to be standardized, regulated, and validated to ensure the safety of the chemical decomposition products for consumption.
Pharmaceutical products contain not just active ingredients but also other components that largely influence the drug’s pharmacokinetics and pharmacodynamics.
There are a variety of excipients contained in FPP dosage form. The type of excipient included in each FPP is determined by the active ingredient contained, route of administration, and intended dosage form. For example, a tablet formulation is an oral dosage form and usually contains binders, fillers, diluents, disintegrators, and lubricants.
How many excipients are used in the pharmaceutical industry?
In almost every drug form, there is an excipient or combination of excipients and there are over 1,000 excipients used to manufacture finished pharmaceutical products.
Initially, excipients consisted of biologically inert, structurally simple, and naturally derived substances such as minerals, wheat, sugar, etc. Nevertheless, in recent times, the production of novel drug formation systems has led to several new and novel excipients such as coprocessed excipients.
How are pharmaceutical excipients classified?
Excipients are classified based on their route of administration (oral, parenteral, and topical excipients, etc.), on origin (Organic and inorganic chemicals), and by functionality (Fillers, emulsifying agents, excipients for direct compression, etc.). These classifications have subdivisions.
The oral dosage forms make up most dosage forms administered to patients due to their formulation, ease of formulation, administration, and transport, among many others. Given this, the main excipients are found in solid dosage formulations and serve as high revenue drivers in the pharmaceutical excipient market. Some main excipients include calcium phosphate, dicalcium phosphate, starch, magnesium stearate, gelatin, and several others.
Role of excipients in drug formation
The traditional use of excipients has been modified by the development of novel drug delivery systems. Beyond increasing the bulk of formulation and simplifying the manufacturing process, excipients perform a variety of roles such as binding ingredients, boosting patient’s acceptance and compliance (by masking unpleasant odors or tastes), enhancing the stability of active ingredients, extending viability and acting as diluents (for example, microcrystalline cellulose, starch), etc.
How do excipients affect the performance of drug products?
The bioavailability of drugs refers to the amount of and rate at which a drug’s active ingredient is being made available at its active site. Although excipients are generally pharmacologically inert or inactive, they can interact with drugs in various dosage forms and influence physiologic factors during absorption, distribution, and elimination.
Excipients that affect the bioavailability of drug formulations are capable of influencing their overall performance, either in a positive way by improving performance and therapeutic effect, or in a negative way by diminishing them. The extent of the impact is dependent on the dose and potency of the formulation, site of absorption, therapeutic window, or rate-limiting factors of drug absorption, and many other factors.
Excipients can result in pharmacokinetic interactions through modulation of intercellular tight junctions, metabolic enzymes, and transporter proteins. The bioavailability of drugs can be affected by excipients’ solubility at absorption sites, liability to enzymatic interaction and degradation, drug-excipient interactions, etc.
Poorly water-soluble drug formulations will result in low and erratic bioavailability. However, lipid-based, surfactant-based, and polymeric excipients have high solubility rates and can improve bioavailability.
Ionizable and soluble excipients can exhibit charge interactions with APIs. For example, positively charged drugs such as polymycin and neomycin can form precipitations in the presence of sodium alginate.
Excipients can also affect the dissolution kinetics of drugs by altering the medium in which the drug dissolves or reacting with the drug. Suspending agents help increase the viscosity of the drug vehicle, which, in turn, reduces the dissolution rate from suspensions. For example, an excessive amount of magnesium stearate in tablet formulations can repel water, and limit the rate of drug dissolution, thereby decreasing the rate of drug absorption and the bioavailability of the drug. Formulation processes such as wet granulation, also have a huge effect on the bioavailability of drugs.
Best practices in dealing with novel excipients
Novel excipients are simply excipients used in drug formulations or through a route of administration for the first time. These excipients could be new chemical products or a previously used and certified excipient that hasn’t been established for use by humans or through a specific administration route.
For example, new solubilizers are required to solve the drug delivery challenges associated with poorly water-soluble drugs. New and novel excipients usually include natural polymer excipients, synthetic polymers, natural polymers modified with/by synthetic polymers, coprocessed excipients, and synthetic polymers modified by other combinations or smaller molecules. Some examples of novel excipients include albumin, Soluplus, Kollicoat Smartseal 3D, etc.
Novel excipients play an essential role in producing and introducing new, advanced, and safer drugs to the pharmaceutical market. However, due to global regulatory policies, there have been various challenges to the development of new excipients. Regardless of this, more companies are adopting innovative excipients to develop novel drug formulations. This has given way for more recent and advanced drug delivery systems to provide safer and more effective drugs for patients and more convenient administration routes. The concept of novel excipients has further broadened the scope of pharmaceutical science.
What drug development challenges do drug sponsors encounter during the manufacturing process that could be addressed by using novel excipients?
With new and significant innovations in the pharmaceutical industry, such as the development of novel drugs for the treatment of rare and orphan diseases, the need for new and advanced excipients to boost drug delivery systems is on the rise. As drug products evolve and increase in structural complexity, the formulation challenges also increase. The use of novel excipients significantly impacts the drug development process, creating various treatment types available to patients, and introducing new therapies into the pharma market.
The development and evaluation of NCEs are costly to process compared to the process of modification of previously established excipients. This issue can be addressed by the development of multi-functional novel excipients, which can perform several roles such as boosting drug stability and bioavailability, controlling API release based on therapeutic needs, etc. These excipients’ production results in a significant decrease in manufacturing cost, hastens the drug development process and improves drug sales and company growth.
Other challenges encountered by sponsors include the need for solubility, stability and permeability modulation, loss of compaction due to wet granulations and high-moisture compatibility of drugs, and increased demands for ideal filler-binders for direct compression, among others.
What are the latest guidelines for novel excipients?
Currently, novel excipients are not evaluated and regulated independently. However, they can be submitted, evaluated, and regulated as part of an IND or IMPD. There are no clear-cut or approved regulatory pathways provided by the FDA or the European Medicines Agency (EMA) to independently assess the efficacy and safety of novel excipients. This present a major barrier and set-back to the pharmaceutical excipient industry and global market, limiting innovation of new and novel excipients regardless of whether they are modifications of existing chemical entities or new chemical entities (NCE).
Although the International Pharmaceutical Excipients Council has been advocating since 2011 for the implementation of a novel excipient approval process by the FDA, the evaluation process hasn’t been put in place. Implementing a novel excipient review or evaluation program will significantly drive the pharmaceutical industry and give room for innovative drug formulations.
Top trends in pharmaceutical excipients
The pharmaceutical excipient industry is rapidly evolving and is continuously searching for new ways to provide innovative and advanced drug formulations for therapeutic purposes. According to a recent study, the global pharmaceutical excipient market is anticipated to experience massive growth over the 2019-2025 forecast period. The market size is expected to reach an estimated value of USD 9.7 billion, at a steady CAGR of 5.8%.
The pharmaceutical excipient markets’ top trends include the increased use of nanotechnology, patent expiries, increased demand for multi-functional excipients, a competitive market landscape, the binders segment taking the lead as the fastest-growing market, and North America possessing the largest share in the global market. The pace of the global pharmaceutical excipient market growth serves as a pharma trend barometer.
Who are the top players in the pharmaceutical excipients industry?
Due to the increasing need for pharmaceutical excipients and the exponential growth of the global pharmaceutical excipient market, there has been a rising competition between excipient manufacturer and excipient supplier in this industry. Amongst the competitor is top players that have largely contributed to the growth of the pharmaceutical excipient industry.
Some of the top players in the pharmaceutical excipient industry include BASF SE, Evonik Industries AG, Lubrizol Corporation, Croda International Plc., Ashland Inc., Avantor Performance Materials Inc., The Dow Chemical Company, Innophos Holdings Inc., Archer Daniels Midland Company, Colorcon Inc., Kerry Group, Merck, Signet, and FMC Corporation amongst many others. The collaborative efforts, expansions, and agreements of these excipient manufacturers to boost the growth of the market.
What is the revenue, sales, and price analysis of top manufacturers of pharmaceutical excipients?
The binder’s segment is anticipated to dominate the pharmaceutical excipient market during the forecast period. In 2017, the pharmaceutical excipients market achieved a total revenue of about USD 4256.3 million, and this revenue is anticipated to grow at a rate of about 6% until 2023. The growing income levels, increasing health expenditures, and improved health awareness globally reflect the many potentials of pharmaceutical excipients.
In addition, the organic segment of the excipient market, including carbohydrates, proteins, petrochemicals, and others, is likely to contribute to the growth of the pharmaceutical excipients market. The rising demand for and application of organic excipients in pharmaceutical industries is expected to drive sales and market growth. Given this, the organic chemicals market share segment is anticipated to grow faster than the inorganic market segment. This benefits the manufacturers and the patients alike.
It is expected that top pharmaceutical excipients manufacturers in North America will record a spike in revenue generation during the forecast period. It would be influenced by the development of advanced infrastructures as well as better investment policies. Several pharmaceutical excipient manufacturing companies in this region participate in projects contributing to the growing demand for novel and advanced drugs.
In addition to this, the massive investments being made are also significant contributors to the anticipated revenue generation. Companies in Europe are also expected to partake in the revenue generation. Also, the Asia Pacific region is expected to experience an increase in revenue generation through structural investments.
Prices of manufactured excipients across various regions globally are dependent on the excipient supply and excipient demand chain within each region. Also, this is dependent on the quality of excipients being produced in each of these regions.
What key factors drive the global pharmaceutical excipients market?
The pharmaceutical drug market size is growing rapidly, and its growth is expected to drive positively impact the growth and size of the pharmaceutical excipient market. In addition to this, several other key factors have driven and are still driving the pharmaceutical excipient market’s growth. Some of these factors include advancement in functional excipient development, increased use and expansion of biopharmaceuticals, large patient population base, the prevalence of chronic diseases, the rapid growth of the biosimilar industry, increasing demand for generic drug, patent expiries, and development of multi-functional and co processed excipient. These key factors have primarily contributed to the growth of the pharmaceutical excipient market during the forecast period.
Excipients play a variety of roles in drug formulations and make up the bulk of almost every drug. The pharmaceutical industry is rapidly advancing through biotechnology to provide safer and more effective drugs for therapeutic purposes. Novel excipients are gaining worldwide attention, and the push for a novel excipient review and evaluation system is growing stronger. In a few years from now, there may be the creation of an established novel excipients evaluation process or system. The establishment of these evaluation processes would allow companies to grow, deliver on-demand health needs to patients, and spur the global pharmaceutical excipients market’s growth.
References
https://www.pharmaexcipients.com/pharmaceutical-excipients-some-definition/
https://www.biopharma-excellence.com/news/2019/12/13/best-practices-in-dealing-with-novel-excipients
https://www.pharmaexcipients.com/wp-content/uploads/attachments/CO5_2013_RGB_80-83.pdf?t=1446883266
https://www.slideshare.net/mobile/SalmanBaig6/novel-excipients
https://www.pharmaexcipients.com/news
References
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Webinar How to Commercialise an Advanced Therapy: Lessons Learned and Future Plans
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31st January 2023
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4pm CET / 10am EST
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Webinar Creating a Circular Economy for the Pharmaceutical Packaging Industry
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18th January 2023
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4pm CET / 10am EST
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Webinar Looking to The Future: What to Expect in the Pharmaceutical Industry in 2023
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13th December 2022
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4pm CET / 10am EST
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Webinar Discover and Make in India: From Generic Leaders to Innovators
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22nd November 2022
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4pm CET / 10am EST
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Webinar Innovating or Stagnating? Reviewing the Current State of Pharma in Europe
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25th October 2022
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4pm CET / 10am EST
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Webinar Improved Delivery of Poorly Soluble Compounds Using Capsule Formulations
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August 25th, 2022
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4pm CET, 10am EST
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Webinar Common Stumbling Blocks When Outsourcing an Injectable Project to a CMO and How to Avoid Them
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June 28th, 2022
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4pm CET, 10am EST
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Webinar The Digitalization of Autoinjector Manufacturing Webinar
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June 22nd, 2022
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4pm CET, 10am EST
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Webinar How Small/Mid-Size Firms are Shaping the Healthcare M&A Market
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April 28th, 2022
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4pm CET / 11am EST / 10am CST
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Webinar Technology & Device Trends Driving Care from Hospital to Home
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March 29th, 2022
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4pm CET / 10am EST
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Webinar Rapid Tech Transfer of Vaccine Products
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February 24th, 2022
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4pm CET / 10am EST / 9am CST
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Position your company at the heart of the global Pharma industry with a CPHI Online membership
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Your products and solutions visible to thousands of visitors within the largest Pharma marketplace
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Generate high-quality, engaged leads for your business, all year round
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Promote your business as the industry’s thought-leader by hosting your reports, brochures and videos within your profile
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Your company’s profile boosted at all participating CPHI events
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An easy-to-use platform with a detailed dashboard showing your leads and performance