L.B. Bohle Coating Technology - Optimal Tablet Coating Uniformity and Highest Flexibility

Continuous wet granulation and drying have long been a hot topic in pharmaceutical research and development (R&D) and industry. However, there is no truly continuous fluid-bed dryer on the market that is suitable for a long process time and that meets the quality requirements described in the present article. This article outlines the experimental testing on a new R&D system (QbCon® 1) for truly continuous granulation and drying. Special attention is paid to the dryer and the resulting granules.
The results show that very narrow and reproducible residence time distributions are achieved in the dryer, which leads to uniform drying of the granules of different size classes. The process delivers consistent quality regarding moisture and particle size of the granules over several hours. When changing the conveying speed of the granules in the dryer while maintaining all other parameters, it was possible to describe the limits for a fixed process/formulation combination, ...

L.B. Bohle is the most innovative technology company in the planning and implementation of machines and processes for the pharmaceutical solids production. As a technology leader in machines, systems, and processes for the pharmaceutical tablet manufacture, we offer retail or all-in-one solutions for the entire production process.
Our products provide added value for your production. We have the optimal machine for your process, from weighing, to wet and dry granulation, grinding and sieving, blending, tablet coating, tablet checking through to product handling. We have installed several thousand systems around the world, standing out with safety, efficiency, longevity, and resource-protecting production.