APPLIVER® FIBROSIS

APPLIVER® is the new product obtained by the ABR innovative biotechnological platform NATRISE®.
APPLIVER® is a freeze-drying Cydonia oblonga  fruit stem cells culture. The  Cydonia oblongais an apple-shaped fruit, with a delicious aroma and it is known for its exceptional health activities since ancient times.
APPLIVER® treatment shows a significant decrease of the cytokines production as TNF-α both in serum and in liver tissue.
The prominent production of fibrillar type 1 collagen is associated with extracellular matrix remodelling and liver fibrosis.  When APPLIVER® is administered, the production of the collagen was decreased both on gene and protein level.