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10 Aug 2021

Bachem & Novo Nordisk Redesign SPPS for Green Chemistry

SPPS reactor in Bubendorf, Switzerland

In our studies in collaboration with Novo Nordisk, we set out to identify environmentally benign solvents suitable for large-scale SPPS of peptide therapeutics at ambient temperature by assessing reagent solubility, resin swelling, amino acid coupling and Fmoc-removal efficiency in a collection of REACH compatible neat solvents and selected binary solvent mixtures. These studies have shown that binary solvent mixtures are indeed viable alternatives.

Replacing gold standard solvents to provide a greener alternative: new binary solvents are a good alternative to DMF and mitigate common side reactions in SPPS.

Mentioned Companies
Bachem AG
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