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APIs (Active Pharmaceutical Ingredients)
APIs (Active Pharmaceutical Ingredients) Companies (500+)
APIs (Active Pharmaceutical Ingredients) News
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News Pharma Supply Chain People Moves
The latest appointments and promotions across the pharmaceutical supply chain.14 Mar 2023 -
News The HPAPI supply chain: why manufacturers should care about handling and transportation
An increasing number of drug development pipelines are turning towards the use of HPAPIs to target rare and ‘undruggable’ diseases. In this article, we talk to leading industry experts about how pharmaceutical manufacturers are adapting and...7 Feb 2023 -
News Sai Life Sciences opens new HPAPI manufacturing facility in Bidar, India
A new HPAPI development and manufacturing block is now open at Sai Life Sciences’ Bidar Manufacturing Campus, expanding the CRDMO’s capabilities in small molecule discovery and commercialisation.17 Jan 2023 -
News CordenPharma joins sustainability initiative to achieve Net Zero
The CDMO has joined the environmental initiative looking to align private sector companies with those aims upheld by the Paris Agreement to reduce global warming.5 Dec 2022 -
News Trend Report: The True Cost of API Price Rises
Download our Trend Report to discover what the current landscape of APIs and their pricing means for the pharmaceutical industry in the future.5 Dec 2022 -
News CPHI Frankfurt 2022: Innovator Interviews – Bioiberica
In this series of interviews, we speak to the companies on the CPHI Frankfurt show floor who are driving innovation in pharma for a better healthcare future. We caught up with Mónica Gómez Navarro (Marketing Manager Branded Ingredients), ...28 Nov 2022 -
News CPHI Frankfurt 2022: Innovator Interview – DSM Biomedical
At CPHI Frankfurt we spoke to Anne-Cecile Bayne, Global Science & Innovation Lead Pharma and Medical Nutrition, and Marc Hendriks, Vice President Strategy & Business Development, on their expertise in nitrosamines and business strategy at DSM Biomedica...23 Nov 2022 -
News CPHI Frankfurt 2022: Innovator Interview – CordenPharma
In this interview from CPHI Frankfurt 2022, we speak to Dr Michael Quirmbach of CordenPharma about his role as President and CEO and what CordenPharma is bringing to the pharma industry.15 Nov 2022 -
News Lukang Pharma has launched two new products: Tulathromycin and Levodopa
Shandong Lukang Pharmaceutical Co., Ltd is a leading bio-pharmaceutical enterprise in China.14 Nov 2022 -
News A Comprehensive Pharmaceutical Enterprise with Multi-Field
We are committed to the export of several API and intermediates, such as Azathioprine, Mercaptopurine, Ribavirin etc.25 Oct 2022 -
News CDMO - Health is a Joint Project: Connect to Frankfurt on-demand
In this Connect to Frankfurt session, Emanuele Agnese, Business Development Manager and Pietro Allegrini, R&D Director at Indena, present the ways in which a reliable manufacturing partner in the pursuit of better health outcomes for patients and pharm...11 Oct 2022 -
News Dr. Paul Lohmann® - Your Partner for high value Mineral Salts
With our expertise in the chemical and physical modification of Minerals and our customer-oriented philosophy, we are the ideal partner to turn your ideas into reality. Meet us at CPHI stand #110F50!27 Sep 2022 -
News Lonza adds X-ray powder diffraction to micronisation portfolio in Monteggio (CH)
Lonza expands solid-state characterisation services for polymorph and solid-state properties of APIs with the addition of X-ray powder diffraction to its portfolio.25 Aug 2022 -
News Connect to Frankfurt - Five reasons to tune in
Get a jump-start on your CPHI Frankfurt experience with exclusive access to our online event platform.23 Aug 2022 -
News Artificial intelligence used to uncover ‘dark matter of the plant kingdom’
Brightseed uses its AI-enabled platform to detect natural bioactives important to human health, also known as ‘nature’s dark matter’2 Aug 2022 -
News WuXi STA launches new HPAPI production facility in China
The new plant features flow chemistry and milling technology, as well as reactors up to 3,000 liters1 Jul 2022 -
News Supply chain disruptions continue, but is the end in sight?
Supply chain disruptions have become the new normal. Recurring pandemic waves, inflation, trade jitters and a war in Europe have done little to quell C-suite anxieties.28 Apr 2022 -
News Onyx Scientific expands small molecule CMC services with new UK facility
The contract development and manufacturing organisation (CDMO) has completed the first phase of its multi-million-pound development.28 Apr 2022 -
News Bora Pharmaceuticals invests $10M to expand oral solid dose capabilities at two sites
The investment will expand operations over two years at facilities in Taiwan and Canada21 Apr 2022 -
News CPHI North America Lookahead: Facilitating ‘meaningful conversations’ on needs and solutions
CPHI NA takes place as a SMART event this year, with online learning and networking from May 9-27 and an in-person event from May 17-19 in Philadelphia, PA.19 Apr 2022
APIs (Active Pharmaceutical Ingredients) Products (2500+)
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Product Intermediates and API Plant to Lease or Purchase/Operate In Place
PRODUCTION AREA OVERVIEW
• (1) Reactors (SS, GL, Hastelloy): 3.4 – 16 m3 • (2) Centrifuges (Hastelloy): 1,600 mm diameter • (2) Conical Dryers(Hastelloy): 3 m3 Other process steps: Distillation, Filtration, Sieving & Milling
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Product Tropicamide
C2 PHARMA provides a wide range of active pharmaceutical ingredients (APls) and complex chemical compounds obtained from synthetic and natural origins which includes Tropicamide.
As a 0.5% and 1% topical ophthalmic solution applied to the cornea of the eye, Tropicamide is useful in inducing mydrias... -
Product Atropine Sulfate
C2 PHARMA provides a wide range of active pharmaceutical ingredients (APls) and complex chemical compounds obtained from synthetic and natural origins which includes Atropine Sulfate.
Atropine Sulfate is helpful in controlling conditions such as spastic bladder, infant colic, renal and biliar... -
Product Ectoine, (S)-2-Methyl-1,4,5,6-tetrahydropyrimidine-4-carboxylic acid
VIO Chemicals offers a broad range of APIs through its wholly-owned subsidiary in Greece, VIO AG Pharmaceuticals S.A. VIO Chemicals is currently developing Ectoine. Products which are subject to patent protection are currently not offered or made available in Germany and in countries where patents are i... -
Product Tapentadol
VIO Chemicals offers a broad range of APIs through its wholly-owned subsidiary in Greece, VIO AG Pharmaceuticals S.A. Currently, VIO Chemicals is developing Tapentadol API. Products which are subject to patent protection are currently not offered or made available in Germany and in countries where paten... -
Product Polymyxin B sulfate
Polymyxin B sulfate is a mixture of sulfates of polypeptide antibiotics active against Pseudomonas aeruginosa and other Gram-negative bacteria.
Indication: Used in the treatment of acute urinary, meningeal or blood stream infections due to Pseudomonas aeruginosa and other ... -
Product Amphotericin B
Amphotericin B is a mixture of polyenes active against a wide variety of fungi e.g. Aspergillus, Candida and Cryptococcus species.
Indication: Used in the treatment of severe, invasive, potentially life-threatening fungal infections (mycosis) typically in immunocompromised patients. q... -
Product API Pharmaceutical Plants and Equipment - Used Equipment and Complete Sites Available
IPP has available complete pharmaceutical plants that can be operated in place as well as relocation.
We have recently acquired pharmaceutical systems in both API and Formulation that can be moved to your plant site saving your projects 50-60% of the equipment value versus new. You can also save... -
Product Crotamiton (CEP)
Transo-Pharm Handels-GmbH offers a wide range of API products which includes Crotamiton (CEP). It belongs to API category. Contact us for more information. -
Product Digoxin (CEP / US-DMF)
Transo-Pharm Handels-GmbH offers a wide range of API products which includes Digoxin (CEP / US-DMF). It belongs to API category. Contact us for more information. -
Product Hydrochlorothiazide
Therapeutic Area: Cardiovascular system • EU DMF available • US DMF no. 17599 available • Japanese DMF available • CEP available
Indication: Hydrochlorothiazide is a diuretic drug of the thiazide class that acts by inhibiting the kidneys' ability to retain water. This reduces the volum... -
Product Pentoxifylline
Therapeutic Area: Cardiovascular system • EU DMF available • US DMF no. 20976 available • Chinese DMF under registration • CEP available
Indication: Pentoxifylline improves blood flow through peripheral blood vessels and therefore helps with blood circulation in the arms and legs (e.g. intermi... -
Product CARBOWAX™ SENTRY™ Polyethylene Glycol (PEG)
CARBOWAX™ SENTRY™ PEGs common applications include: carrier/plasticizer in gel capsules, base for face/neck lotions, providing formulation stability in toothpaste, binder for tablets, shampoo wetting agent, and more. CARBOWAX™ SENTRY™ PEGs are available in average molecular weights ranging from 3... -
Product Processing aids – surfactants: TRITON X-100 & TERGITOL 15-S-9
Large Molecule (Biologic) API Production:
Dow’s TRITON™ and TERGITOL™ surfactants are used to inactivate virus envelopes, lyse cells, and buffer RNA extraction solutions. As the only producer of TRITON™ X-100 (CAS No: 9036-19-5), which has been trusted by the industry for deca... -
Product Acyclovir
Hetero Drugs Limited offers a wide range of active pharmaceutical ingredients for regulated market which includes acyclovir. Contact us for more information. -
Product Adefovir Dipivoxil
Hetero Drugs Limited offers a wide range of active pharmaceutical ingredients for regulated market which includes adefovir dipivoxil. Contact us for more information. -
Product Active Pharmaceutical Ingredients
We cover the spectrum from clinical to commercial services to outsource active pharmaceutical ingredients (APIs), registered intermediates (RIs), and registered starting materials (RSMs). DSM services encompass most commercially-used chemical conversions. Some of our specialities include:
•Chiral te... -
Product Manufacturing Solutions
We are GMP-certified for the manufacturing of IMP clinical batches (Phases I-III) as well as commercialized products. Our laboratories are prepared to work with over 30 key pharmaceutical technologies, all API types from OEB classes 1-5 and narcotics, innovative technologies, hard-to-make formulations in a... -
Product SIMULATED MOVING BED CHROMATOGRAPHY (SMB)
KD Pharma is a contract manufacturer that develops products in the pharmaceutical space by employing state-of-the-art technology. Since its inception in 1988, KD Pharma has focused on utilizing cutting edge technologies to develop and manufacture exceptional quality APIs. These twin pillars of technology a... -
Product Inhalation Product Analysis and Testing
Inhalation product analysis and testing services include particle size and droplet characterization, delivered dose testing, as well as aerodynamic particle size analysis – for pressurized metered-dose inhalers (PMDI), dry powder inhalers (DPI), nebulizers, and soft mist inhalers. Our Good Manufacturin... -
Product Diosmin
CEP & DMF | IP: Solvent-Free method GMP
HTBA is the world’s largest producer of Diosmin (Free Market).
Venotonic for chronicle treatment of CVD, varicose veins, hemorrhoids, spider veins, and heavy legs syndrome. Promotes blood circulation and addresses vascular discomfort. ... -
Product Polyglykol
Effective and high-purity ingredients including a complete range of Polyglykols (Macrogols) our universally applicable pharmaceutical polymers, with various molecular weights, supported by CEP certification and DMF type II documentation. -
Product Sodium Hyaluronate Hyaluronsan HA-AM
Sodium Hyaluronate (API): MW 600 - 1,200 kDa Certificates: GMP certified sodium hyaluronate powder extracted from chicken comb, DMF in Japan, USA, China and South Korea
Application: Used in the pharmaceutical preparations for knee-osteoarthritis injection,... -
Product Penicillin G Clemizole Sterile
Penicillin G Clemizole + 0,5% Lecithin + 0,3% Polysorbate
Sterile Powder
MOQ: 440 Kg
Shelf life: 5 years
DMF: Available
GMP: Available -
Product Active Pharmaceutical Ingredients
Actylis manufactures and supplies a wide range of active pharmaceutical ingredients (APIs) to many generic drug companies in the pharmaceutical industry. Active pharmaceutical ingredients are the active components of a drug product. Actylis is a valued partner in our clients' effort to develop and mar... -
Product Diazepam
FIS produces a wide range of API's which includes Diazepam. It is commercially available. Contact us for more information. -
Product Manidipine Hydrochloride
Manidipine Hydrochloride,Manidipine,Manidipine HCl,cas#89226-75-5
Used to prepare related preparations of manidipine hydrochloride for treating hypertension. -
Product PVP-iodine Complex
PVP Iodine complex kills microorganisms on contact, is safer and easier to use than classic iodine preparations and has low systemic toxicity. In addition, it forms films that protect open wounds. Because it is soluble in water as well as in organic solvents, it an be formulated in powders, tablets, lozeng... -
Product Amisulpride
LEBSA manufactures in compliance with full GMP conditions a range of Active Pharmaceutical Ingredients (APIs) which includes Amisulpride (CAS number 71675-85-9). It is a neuroleptic/ antipsychotic agent manufactured in our unique European GMP manufacturing plant ... -
Product Ashitaba Leaves Extract
• Name- Ashitaba • Specifications- IH • Botanical Source- GERD For more information, visit www.chereso.net -
Product N-Nitroso Ambroxol
Catalogue No: VE007666
Molecular Formula: C13H17Br2N3O2
Molecular Weight: 407.10 g/mol
IUPAC Name: N-(2-amino-3, 5-dibromobenzyl)-N-(4-hydroxycyclohexyl)nitrous amide
Status: In-stock
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Product Heparin Lithium
It is an anticoagulant commonly used in chemistry and specially chemistry testing and routine clinical chemistry determination. It is the recommended anticoagulant for many determinations using whole blood or plasma specimens because of its minimal chelating properties, minimal effects on water shifts,... -
Product XanGuard® Lutein and Zeaxanthin
Lutein and Zeaxanthin are the main pigments in the macular area of the retina and play important role in eye health. They can be found in green cauliflower, spinach, egg yolk and other foods, extracted from marigold is the first choice for industrial production.
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Product Flurbiprofen,
Azilsartan,
Epalrestat,
Fimasartan,
Flurbiprofen,
Loxoprofen Sodium,
Nizatidine,
(3-Carboxypropyl)triphenylphosphonium bromide,
(methyl 2-ethoxy-1-((2'-(5-oxo-4,5-dihydro-1,2,4-oxadiazol-3-yl)-[1,1'-bi... -
Product Polysorbate 80 / Hedisan-80 (API)
Hedisan-80 is a high quality Polysorbate 80. The product is produced at Kolb in Hedingen. The site has been authorised by SwissMedic to manufacture and distribute active pharmaceutical ingredients and is subject to regular GMP inspections. Kolb has a broad portfolio of non-ionic surfactants with... -
Product RoSS®: Protecting single-use bags
Protect your preferred single-use bioprocess containers: RoSS shells - abbreviated for Robust Storage and Shipping - reduce product loss towards 0%. Compatible with all available sizes and types of single-use bags, RoSS enables standardized and scalable end-to-end process solutions for fluid managemen... -
Product Clarithromycin Taste Masked Coated Granules
White to off white tasteless free flowing granules.Recomended for Dry Syrup / Suspension
Available activities 27.5%, 30%, 33%, 38%, 42%, & 43.75% -
Product Antazoline Hydrochloride
Fields of Application: Conjunctivitis. Antazoline Hydrochloride is an ethylenediamine derivative with antihistaminic properties and is used in conjunction with a vasoconstrictor for ocular allergies. -
Product Ulinastatin
Jiangsu Aidea Pharmaceutical Co.,Ltd. offers a wide range of products which includes Ulinastatin. It is a glycoprotein which contains 143 amino acids with molecular weight of 67000±5000 Dalton, extracted and refined from human urine. It is a natural broad-spectrum proteinase inhibitor w... -
Product Guaifenesin
Anzen Exports provides wide range of pharmaceutical products which includes Guaifenesin. It belongs to active pharmaceutical ingredients category. Contact us for more information. -
Product Cannabinoid actives / CBD APIs
Our CBD API has 0% THC or other impurities in line with ICH guidelines and no pesticides, herbicides, or heavy metals. It has been tested by a World Anti-Doping Agency (WADA) lab, NSF and Informed Choice, confirmed for the absence of THC and banned substances. The product follows ICH Q7 regulations and is ... -
Product ALTRENOGEST
Veterinary use. It is a synthetic progestogen (sex hormone), programmer and synchronizer of the estrous cycle in swine and horses. -
Product Acepromazine maleate [vet]
WELDING GmbH & Co. KG founded in 1955, independent, family-owned. Global marketing, sourcing and distribution of APIs for human and veterinary medicines, additives for the food and feed industry.
Development of finished products, including services related to IP evaluation, regulatory affairs ... -
Product Lithium Carbonate
API - Active Pharmaceutical Ingredient
- Therapeutic Area: Bipolar Disorder and Major Depressive Disorder as adjunctive
- Status: DMF (Drug Master File) ready
Blanver fully respects the patents’ expiration dates in all countries*
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Product Amiodarone HCL
SPC Life Sciences Pvt Ltd offers a wide range of products which includes: Amiodarone HCL Therapeutic category: Antiarrhythmic . Contact us for more information. -
Product Acheflan Aerosol
Ache Laboratorios Farmaceuticos S/A offers a wide range of products which includes acheflan aerosol. Features: it is used to treat symptoms and major ills and are available only from a medical prescription, according to the need of each patient. It should be administered under the supervision and guidance ... -
Product Quali®-D (vitamin D)
Dsm innosyn offers wide range of products which includes quali®-d (vitamin d). Feature: it comprises a group of fat-soluble compounds essential for maintaining the mineral balance in the body; the vitamin d form synthesized in humans is called ‘cholecalciferol’ (vitamin d3). Because cholecalciferol is synt... -
Product Active Pharmaceutical Ingredients
Smart Ingredients offers a wide range of APIs which are manufactured in compliance with standards of Good
Manufacturing Practices (GMP) and appropriate regulatory frameworks (CEP, DMF, etc.). Along with our experienced technical Teams, we exceed your expectations with class-leading service, support,... -
Product Drug Substances
With more than 30 years of experience in Pharma, Midas has demonstrated a proven track record & expertise in sourcing and supplying Drug Substances (APIs) required for the pharmaceutical production. We work closely with our manufacturing partners around the globe and are active in more than 700 dr... -
Product Small Molecules
Our multi-patented Controlled Expansion of Supercritical Solutions (CESS®) technology enables the creation of API nanoparticles directly from solution. The process can be applied to most small molecules, with a high success rate of 80-90%.
CESS® is a bottom-up method of recrystallization that wo... -
Product Paracetamol
SEQENS offers wide range of products which includes paracetamol. Contact us for more information. -
Product Mediprene A
Overmoulding is a powerful technique that allows the production of finished parts in soft and hard material combinations without trimming or assembly.
It offers many design and product advantages, allowing designers to differentiate products while meeting important us... -
Product Elimreal
ELIMREAL® is a new patented exclusive natural and powerful elimination complex that stimulates natural body drain functions and body detoxification. ELIMREAL® efficiency has been demonstrated clinically during double-blind against placebo studies, increasing Urinary Volume and Frequency. Approved worldwide... -
Product Combination Products
A combination product is the combination of a physical part and a drug which can be implanted or worn on the body for long-term treatments. Combination products offer several advantages when compared with drug delivery via oral, injection, and infusion methods:
Controlled release of the Ac... -
Product Articaine or carticaine
Moehs Fine Chemicals provides a wide range of generics which includes articaine or carticaine under GMP guidelines. FDA approved site. It belongs to local anesthetic- antiarrhythmic category. Packaging: Fiber drum 50 Kg. CEP, EDMF, USDMF available Contact us for more information... -
Product Ursodeoxycholic Acid
PharmaZell GmbH manufactures a wide range of commercial API's which includes Ursodeoxycholic Acid, Ursodiol, UDCA. Therapeutic area: Cholelitholytic agent. Grades: Standard. micronized. Regulatory Documentation: CEP, EU DMF. Pack size [kg]: 20, 25. Contact us for more information. -
Product APETAMIN
Til healthcare pvt ltd provides wide range of appetite stimulant which includes apetamin. Feature: cyproheptadine + multivitamin + lysine. Dose: 2 mg. Dosage form: syrup. Shelf life: 18. Packaging: 120 & 200 ml. Contact us for more informations. -
Product Animal Health API
Flarer S.A. offers a wide range of products which includes Animal Health API. Contact us for more information. -
Product Suitable Supports
Offering Tailor-made catalysts for optimum productivity in your process.
Hindustan Platinum is a leading manufacturer of precious metal catalysts that play a pivotal role in chemical industries, owing to their activity, selectivity and recyclability. Our catalysts are abundantly suppli... -
Product 5 HTP
L-5-HYDROXYTRYPTOPHAN: NLT 99.0%
PHARMA USE
InsomniaPost-anoxic myoclonus
Anxiety and depression
Migraines
DIETARY USE
Sleep improvement
Promotion of positive moods and emotions
Appetite control and adherence to slimming programs -
Product HPAPI Platform
Responding to the rising number of custom HPAPIs demand, Angelini Fine Chemicals expands its HPAPI capacity. With over 50 years of CDMO experience, Angelini Fine Chemicals is at the forefront of chemical development and cGMP manufacturing of HPAPIs to serving brand pharmaceutica industry. The new Angel... -
Product APISAL (Sodium chloride API)
For the exceptionally high requirements in pharmaceutical manufacturing processes, we produce pure pharmaceutical salt exceeding the purity requirements stipulated in the pharmacopoeias. All steps of production, analysis, and quality control comply with these strict principles. APISAL® is obtained from a p... -
Product Lansoprazole
INTEGRIN LIFE SCIENCES PVT. LTD. offers wide range APIs and Intermediates which includes Lansoprazole. Contact us for more information. -
Product Thyroid
BIOFAC manufactures Thyroid Powder from porcine thyroid gland according to USP with standardized content of both T3 and T4 hormones.
The oral products with Thyroid Powder is a well-known option for patients with hypothyroidism. Thyroid Powder is easily absorbed by human body and shown to ha... -
Product New Drug & Chemical Services
1.Custom Synthesis 2.R&D of Synthetic Processes and Custom Manufacturing 3.Contract Manufacturing Service 4.CMC Service for New Drugs
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Product Salicylic acid
Fischer Chemicals AG offers a wide range of active pharmaceutical ingredients. Contact us for more information. -
Product FERRIC CITRATE
Greenish brown to brown hygroscopic powder. Powder & DC grade available. DMF & Patent available -
Product R&D Service
1. Process R&D
1) Synthetic route scouting
2) Process Optimization
3) Impurities fate/purge study
4) Control strategy: PAR & DOE
5) Technology trasnfer
6) Procative trouble shooting
7... -
Product Z-Arg(Pmc)-OH.CHA CAS:112160-33-5
We are very compeitive on Z-Arg(Pmc)-OH.CHA CAS:112160-33-5 with high quality on commercial scale
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Product Drug Substance
Recipharm has more than 25 years’ experience in drug substance development and manufacturing. We are ideally placed to deliver a wide range of drug substance services from our dedicated development facilities around the world. -
Product CDMO Services
Strong R&D with over 100 patents filled and 4 cGMP manufacturing sites offering from pre-clinical to commercial supplies (from grams to multi-tons).
With available capacity to start supporting your project now! -
Product Pactol Cough Adults
MASENZ DANYA GROUP SL offers a wide range of products which includes pactol antitussif (adult). Contact us for more information. -
Product Sodium Hyaluronate (Hyaluronic Acid API): MW 250-2300 kDa
Sodium Hyaluronate (Hyaluronan, HA) - TYPE I: MW 250 - 2300 kDa
Ultra-Pure HA
Pharmaceutical Grade (Injection suitable)Certificates: GMP, CEP, DMF
Our Intrinsic Viscosity is from IV 0.7 to 2.8 m3/Kg
Sodium hyaluronate is a polysaccharide found... -
Product Diphenyacetic Acid
Diphenylacetic acid is a monocarboxylic acid that is acetic acid where the methyl hydrogens have been replaced by two phenyl groups respectively. It has a role as a xenobiotic metabolite.
Shree Ganesh Remedies Limited is one of the leading manufacturer and supplier of the Diphenyaceti... -
Product Algal DHA
Algal DHA, a vegetarian, sustainable and highly stable algal Omega-3 DHA produced from the microalgae Schizochytrium. Although fish oil is well known for having a high content of EPA and DHA, micro algae is the original source of marine omega-3. Algal DHA is the DHA in Algal oil that is derived directly fr... -
Product Glass Vials
Momentive Technologies, a global leader in the development and manufacture of ultra-high-purity fused quartz products, has been trusted for years in processes where durability in extreme conditions is required – from semiconductor and water purification to the consumer electronics and telecommunication... -
Product Colloidal Silver EP / Collargol
Laboratorios Argenol offers wide range of pharmaceutical products which includes Colloidal Silver. Characteristics: green or bluish-black metallic shiny flakes or powder, hygroscopic. Solubility: Freely soluble or soluble in water, practically insoluble in ethanol and methylen chloride. Contact us for more... -
Product Active Pharmaceutical Ingredients and Intermediates
We provide customized chemical synthesis for active pharmaceutical ingredients from concept to commercial supply.
We are an industry-leading integrated development and manufacturing service provider for small molecule drug substances and their intermediates.
Chemistry is c... -
Product BAC
Benzalkonium Chloride Ph.Eur., USP/NF (BKC/BAC/BAK) CAS No. 8001-54-5
Consists of Benzyl (dodecyl) dimethyl ammonium chloride (C12 approx. 65%) and Benzyl (tetradecyl) dimethyl ammonium chloride (C14 approx. 35%). Other chain length distributions are also available. Available with more ... -
Product PHSE UK
• Specialty courier dedicated to clinical trials and the drug development process • Import and export from more than 70 countries including 3rd country and direct to site 24hr operations 7 days per week, 365 days per year • Walk in cold chain facilities for high volume supply of temperature contro... -
Product Calcium Levomefolate
Active Pharmaceutical Ingredient (6S)-5-Methyl-tetrahydrofolic Acid Calcium Salt is used as a food supplement for folate deficiency and also in cases of depression disorders.
6S)-5-Methyl-tetrahydrofolic Acid Calcium Salt is the isomerically pure form of 5-Methyl-tetrahydrofolic, Acid Calcium Sa... -
Product Diminazene Aceturate
NGL Fine-Chem Ltd manufacturers wide range of pharmaceutical products which includes Diminazene Aceturate. It belongs to API's animal health products category. It is a lemon yellow powder, odorless. Therapeutic Category : Antiprotozoal Contact us for more information. -
Product inline mixer CMX with 2 dispersing stages
The IKA CMX 2000 is an inline mixer for rapid and homogeneous incorporation of powders into liquids. The circulation of fluid creates a powerful vacuum in the machine that draws in the powder. This ensures an agglomerate free integration of problematic powders that are not easily incorporated into the liqu... -
Product Highly Potent API
CARBOGEN AMCIS has state of the art facilities and controls to handle both drug substance and drug product of the highest potency and toxicity, under cGMP. Our dedicated containment facilities use a containment methodology, utilizing barrier isolation technology and Rapid Transfer Ports (RTPs), combined wi... -
Product Manufacturing
Custom API Manufacturing, Fermentation, Finished Dosage Form, High Potency, Lipid Nanoparticle, Rare / Orphan, Stability & Release Testing, Sterile Fill Finish, APIs & Intermediates, Fine Chemicals
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Product Custom API
AbbVie’s API site has the flexibility to run multiple chemical processes simultaneously to support late development phase to commercial products including highly potent drug containment up to OEL 3A (1 µg/m3). State of the art QC laboratories integrated across a highly experienced team focused on commercia... -
Product Active Pharmaceutical Ingredients
OLON is an Italian company world leader in the Active Pharmaceutical Ingredients (APIs) production, using synthetic and biological processes for Generic market as well as in Contract Development and Manufacturing (CDMO).
Always considering human safety and environmental security, OLON hand... -
Product Gaskets for pharmaceutical applications
Dockweiler gaskets ensure the availability of various materials from approved high quality vendors to complete our high quality product range of tubular components. Dockweiler guarantees total traceabilty even for gaskets: laser engraved, lipped gaskets with material certification. Dockweiler gaskets are c... -
Product Early Phase Support
From the lab to the plant:• Development of new, scalable API route options
• Process safety and hazards assessment
• cGMP starting material assessment& establishment of regulatory concept
• Starting material & other raw materials sourcing and development
• Polymorph screening & salt... -
Product Kijimea® Synpro 20
Kijimea® Synpro 20 is a dietary supplement containing 20 selected microcultures that occur in the natural intestinal flora of humans. In addition, Kijimea® Synpro 20 contains choline, FOS, inulin and biotin, which helps to maintain normal mucous membranes.
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Product CordenPharma Peptides Platform
Your Expert Partner for Peptide APIs
• >> Proven track record delivering world class manufacturing services from early stage to commercial supply, including complex products (e.g., Linaclotide, Enfuvirtide, Mifamurtide, Eptifibatide, Glatiramer, GLP analogues). • >> Proprietary... -
Product Pharmx - High Shear Granulators
PHARMX® high-shear granulators are fully customizable bottom-driven mixing systems engineered to provide homogeneous mixing and efficient granulation. Equipped with an in-bowl, bottom-driven mixing impeller and side-mounted chopper, the PHARMX ensures uniform mixing across a range of R&D, pilot, and pr... -
Product Chlorthalidone
CAS Number: 77-36-1
Formula: C14H11ClN2O4S
Molecular Weight: 338.8
API
Aplication: Diuretic - Hypertension treatment
DMF, CEP, KFDA, GMP, USDMF
www.menadiona.com
[email protected] -
Product NORMOBOWELL
Medical Device for the management of Irritable Bowel Syndrome.
MEDICAL DEVICE CE 0477 CLASS IIB -
Product Triptorelin Acetate
Product Name:Triptorelin Acetate;Cas No. 57773-63-4;Sequence Pyr-His-Trp-Ser-Tyr-D-Trp-Leu-Arg-Pro-Gly-NH2;Molecular Formula C64H82N18O13;Molar Mass 1311.5 g/mol;Purity ≥98%;Impurity ≤0.5% ;Storage Temperature 2-8℃;Packing Size 1G/Bottle, 10G/Bottle,50G/Bottle or at customers reqirement.
Triptorelin Ace... -
Product API PORTFOLIO
Hovione's APIs offer impeccable chemical purity and unique product performance.
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Product Pharmacopea Analysis
Neotron SpA provides wide range of analytical control according to EP, USP, JP, BP, CHP.
Contact us to ask for tests in relation to your monograph of interest. -
Product Active pharmaceutical ingredients services
Taking advantage of our global presence with offices located in all the key areas for the chemical and pharmaceutical business, Summit Pharmaceuticals Europe can provide a large range of different APIs.
Due to our long experience and consolidated relationships with our partners we can provide material f... -
Product Sunvidone ® PI Solution
SUNVIDONE PIS is a deep-brown solution of Sunvidone PI in water. They are stablebroad spectrum and non-selective germicidal antiseptics and disinfectant which havedetoxified iodine, no general odor, no loss of iodine, no detectable vapor pressure. They arewater soluble, Film-forming and effective in dilute... -
Product Diosmin
Diosmin EP8.3 EP9 BP. 90%, 92%, 95%;
Diosmin/Hesperidin(90:10)
Particle Size: Non-micronized, Micronized, Granulated
EUGMP, CEP, Written Confirmation (EU), ISO, DMF
Annual Capacity 600 tons/ year -
Product Contract Manufacturing Solutions
GVK BIO offers long term Contract Manufacturing Solutions in development, validations, DMF filing, manufacturing of New Chemical Entities (NCE), Active Pharmaceutical Ingredients (API) and Intermediates.
Capabilities:Environment friendly routes under GMP conditions
Robust and cost-effective p... -
Product Nitrosamine Impurities Testing
SGS Life Sciences has considerable expertise in the method development of nitrosamine determination in pharmaceutical products. SGS has established a specific method for NDMA which can be applied to various different matrices. Alternatively, a platform method, based on trace-level detection by LC-MSMS, is ... -
Product Butorphanol Tartrate
Butorphanol Tartate is a morphinan-type synthetic opioid analgesic.
It is approved by NMPA. -
Product Mexiletine hydrochloride
Active Pharmaceutical Ingredient. Arrhythmia indication. Cardiovascular therapeutic area. -
Product Thermo Compression distillation system/ Vapour Compression distillation system
Thermo Compression distillation system is the most economical method of producing highest quality WFI. The system is available in wide range of production capacities, from 100 LPH to 5000 LPH. The system is fully automated, in compliance with GAMP5 standards and is also available to comply with 21... -
Product Cannabidiol (CBD)
Our product is an API-grade CBD purified naturally from the Hemp Plant. Cannabidiol (CBD) is a phytocannabinoid, a non-psychoactive molecule present in the Cannabaceae family of plants. CBD has been demonstrated as an effective treatment of epilepsy in several clinical trials. There is also preliminar... -
Product Fomepizole
An orphan drug API used in its finished form (injectable) is the only known antidote for methanol and ethylene glycol poisoning in the world. Available for all global markets along with DMF support.
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Product Nifuratel
Nifuratel is a nitrofuran antibacterial drug, which is researched by Italy Poli Industrial Co. Ltd. forty years ago and applied for a Belgium patent in 1962, and is used widely to treat vaginitis caused by bacteria, trichomonas and mold etc. -
Product Hydrochlorothiazide
Hydrochlorothiazide is a benzothiadiazine that is 3,4-dihydro-2H-1,2,4-benzothiadiazine 1,1-dioxidesubstituted by a chloro group at position 6 and a sulfonamide at 7. It is diuretic used for the treatment of hypertension and congestive heart failure. It has a role as a xenobiotic, ... -
Product Active pharmaceutical ingredients (APIs)
High quality APIs to accelerate your generic product launches. Catering to leading innovator and generic companies across the world, Dr. Reddy’s is recognized as one of the largest API suppliers worldwide. The launch of Dr. Reddy’s XCEED – a digital customer service platform - gives customers inst... -
Product Hyatrue® — Pharmaceutical Grade Sodium Hyaluronate
Hyatrue® is a pharmaceutical grade sodium hyaluronate which can be used as an API or excipient for drugs and medical devices in ophthalmic preparations, intra-articular injections, anti-adhesive preparations, topical preparations for wound healing and soft tissue filler, etc. Hyatrue® sodium hyaluronate ... -
Product Tulathromycin
Tulathromycin is a newly listed macrolides semisynthetic antibiotic for animals,It is mainly used For the prevention and treatment of bovine or swine respiratorydisease caused by actinobacillus pleuropneumoniae, mycoplasma, pasteurella, etc.. Its efficacy is better than that of the widely used macrolides a... -
Product SensiKin range
Oral hygiene in cases of hypersensitivity.Mouthwash and toothpaste for daily care. Gel and spray for intensive care. Synergistic action of Potassium Nitrate and Sodium Fluoride. -
Product Ethacrynate Sodium
Etacrynic acid (INN) or ethacrynic acid (USAN), trade name Edecrin, is a loop diuretic used to treat high blood pressure and the swelling caused by diseases like congestive heart failure, liver failure, and kidney failure.
Biophore's Ethacrynate Sodium :
US DMF Available -
Product Epsom salt USP Food grade
Name:Magnesium SulphateCAS No.:7487-88-9 Other Names: Epsom Salt , Magnesium sulphate MF: MgSO4.7H2O EINECS No.:231-298-2 Place of Origin: Hebei, China (Mainland) Grade Standard: Medicine Grade Purity:99.9% Appear... -
Product Cathejell Lidocaine
Montavit GmbHoffers a wide range of products which includes cathejell lidocaine. Active ingredient: lidocainecathejell lidocaine - anaesthetizing gel is a catheter lubrification with local anaesthetic effect for instillation into the urethra before catheterization, pain relief through anaesthetic effect, c... -
Product Ortho-Nitro benzaldehyde intermediates
High quality but low price with high reputation at home and abroad. -
Product Carprofen
It is used in the treatment of rheumatoid arthritis, osteoarthritis, acute gout and tendonitis etc. -
Product Acetaminophen
We have all kind of paraceatamol powder, such as standard powder, fine powder, dense powder, semi-dense powder, mironized powder, crystal etc. -
Product 2-(4-chlorophenylaceto)benzoic acid
Jiangsu Lingyun Pharmaceutical Co., Ltd. offers wide range of intermediates which includes 2-(4-chlorophenylaceto)benzoic acid. Contact us for more information. -
Product Polyglykol
Polyethylene glycols or PEGs as Active Pharmaceutical Ingredients and Excipients used in a variety of pharmaceutical applications. -
Product CX-4945
Inhibitor. Catalog ID # PI-38267
Empirical Formula C19H12ClN3O2 Molecular Weight 349.77
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Product Entecavir
Carelife offers a wide range of products which includes Clindamycin Hydrochloride, Phosphate, Palmitate Hydrochloride.
We also offer:
Iron sucrose
Ferric carboxymaltose
Pemetrexed disodium
Granisetron HCl
Mitoxantrone HCl... -
Product Catalog API & CDMO
Catalog API's : ~200 API's availableCDMO Services: Custom Development through Commercial Launch -
Product Carbomer 974P
Application:For oral care such as Aqueous Toothpaste,AnhydrousToothpaste, Mucoadhesive Application, Denture Fixate etc. and For pharmaceutical excipients such as Ultrasonic coupling agent,tablet binders, suspension stabilizers, extended-release polymers, mucoadhesive aids, and bioavailab... -
Product Solifenacin Succinate
Solifenacin is a medicine used to treat symptoms of an overactive bladder -
Product Nystatin API
Nystatin Standard, Nystatin Micronised, Nystatin CompactedPharmaceutical form: Oral Suspension, Tablets, Capsules, Creams, Ointments, Topical Powders, Pessaries
Therapeutical class: Antifungal
Contact us for more information. -
Product Amygdalin
Shaanxi Jiahe Phytochem Co Ltd offers a wide range of products which includes amygdalin. It belongs to ingredients category. It is a glycoside initially isolated from the seeds of the tree prunus dulcis, also known as bitter almonds, by pierre-jean robiquet and a. F. Boutron charlard in 1830. Several other... -
Product Nafamostat mesylate
Nafamostat mesylate is a treatment for anticoagulant for acute pancreatitis that has shown steady growth since it was released domestically in 2004.It was mainly used in several Asian countries and recorded sales of 14.4 billion won in Korea in 2019. Our company has registered KDMF for the first time ... -
Product Active Ingredients
Egis Pharmaceuticals PLC provides a wide range of products which includes active pharmaceutical ingredients. Contact us for more information. -
Product Rapamycin
Chunghwa chem synthesis & biotech co. offers a wide range of api products which includes rapamycin. It belongs to immunosuppressant category. Contact us for more information. -
Product AMOROLFINE HCl
PHARMASYNTHESE - INABATA offers a wide range of products which includes amorolfine hcl. It is useful for the treatment of antifungal. Contact us for more information. CEP obtained in 2018 : R0-CEP 2016-312-Rev 00 -
Product Acyclovir sodium sterile
Acyclovir Sodium Injection is a synthetic nucleoside analog, active against herpes viruses. It is a sterile, aqueous solution for intravenous infusion, Ayclovir Sodium Injection is a synthetic nucleoside analog, active against herpes viruses.
Acyclovir Sodium is the sodium salt form of a... -
Product Pantoprazole
IOL Chemicals & Pharm provides a wide range of active pharmaceutical ingredients which includes dex-ibuprofen. It is white crystalline powder. Usage: NSAID. Contact us for more information. -
Product Aprepitant
Pharmaceutical form: Hard Capsules. Therapeutic category: Prevention of nausea and vomiting associated with moderately emetogenic cancer chemotherapy in adults.
Strengths: 40mg, 80mg, 125mg, 165mg (Not available in the US market).
Contact us for more information.
Pr... -
Product Nitrogenema II
This enclosure is capable of protecting your process by nearly eliminating moisture or oxygen with the flow of inert gas. Don’t spend tens of thousands of dollars on a cumbersome metal isolator, see how the Flow Sciences END Series can solve your application needs.
Achieve and maintain low humidity ... -
Product PharmASep™ Filter Dryer
The PharmASep™ Filter Dryer combines SWECO’s patented separation process with vacuum drying technology to efficiently and effectively filter and dry product while significantly increasing convenience, safety, precision and productivity in critical applications. This documented aseptic pharmaceutical fi... -
Product Balsalazide Disodium Dihydrate
Formosa Laboratories provides a wide range of active pharmaceutical ingredients which includes balsalazide. It belongs to anti-inflammatory and analgesic agents category. Contact us for more information. -
Product Sodium Hyaluronate (HA)
Miat offers Sodium Hyaluronate (i.e. HA) obtained by fermentation from Streptococcus equi subsp. Zooepidemicus, intended for Pharmaceutical (available IV range 0.6-3.6 m3/kg) and Medical Device use (available IV range 0.1-3.6 m3/kg). The offered HA is supported by European documentation i.e. the ... -
Product Albendazole Film-Coated Tablets
Remedica Ltd offers a wide range of products which includes albendazole film-coated tablets. Features: it is broad spectrum anthelmintic. Contact us for more information. -
Product Pharmaceuticals (active pharmaceutical ingredients [APIs]
NAGASE (Europa) GmbH offers wide range of products which includes Pharmaceuticals (active pharmaceutical ingredients [APIs]. It deals in a wide range of products, including raw pharmaceuticals and intermediates, as well as injection drugs for company. Contact us for more information. -
Product Chenodeoxycholic Acid or Chenodiol
ICE S.p.A provides a wide range of products which includes chenodeoxycholic acid or chenodiol. It is a natural substance found in human bile. it's used in the treatment of gall stones disease and it's obtained by synthesis starting from cholic acid. it's used as intermediate for ursodeoxycholic acid manufa... -
Product Paclitaxel API
Phyton commercially supplies paclitaxel API (from Plant Cell Fermentation PCF™). It is inspected by: USP/EP, CEP 2011-324, US DMF 25525, filed in Japan, Korea, China, India. Contact us for more information. -
Product Ascorbyl Palmitate
Jiangxi Tianxin Pharmaceutical Co. Ltd offers a wide range of products which includes ascorbyl palmitate. It belongs to vitamin and derivatives category. Generally used as a nutrition reinforcer and antioxidant and antistaling agent. It is widely used in food and beverage industry. Packaging: 20 kg per car... -
Product IRON SUCROSE
Active ingredient: Iron sucrose
Therapeutic indication: Treatment of anaemia caused by iron deficiency. -
Product Abiraterone acetate
Scinopharm Taiwan Ltd offers a wide range of products with US DMF or EDMF which includes Abirterone Acetate. Contact us for more information. -
Product PRODUCT LIST
ACTH, Abaloparatide, Alarelin, Angiotensin I/II (1-7), Angiotensin II, Arginine Vasopressin, Atosiban, Buserelin, Carbetocin, Carperitide, Desmopressin, Elcatonin, Eledoisin, Etelcalcetide, Fertirelin, GHRP-6, GLP-1 (7-37), Gonadorelin, Goserelin, Icatibant, Lanreotide, Lecirelin, Leuprolide, Lysine Vasopr... -
Product Sodium Hyaluronate - Injection grade
Hyature® is a pharmaceutical grade sodium hyaluronate which can be used as an API or excipient for drugs and medical devices in ophthalmic preparations, intra-articular injections, anti-adhesive preparations, topical preparations for wound healing and soft tissue filler, etc. Hyature® sodium hyalur... -
Product Benidipine HCl
Recordati S.p.A provides a wide range of active pharmaceutical ingridients which includes benidipine HCl. It belongs to antihypertensive category. Contact us for more information. -
Product COATSOME® FE-4040MA3 (DMPE-MAL)
Nof Europe offers a wide range of drug delivery products which includes coatsome® fe-4040ma3 (dmpe-mal). Contact us for more information. -
Product PROSTAGLANDINS
Newchem Spa provides wide range of active pharmaceutical ingredients which includes Prostaglandins. Contact us for more information. -
Product Meropenem Trihydrate (sterile) (API)
Savior Lifetec Corporation manufactures sterile carbapenem antibiotic which includes meropenem (sterile bulk). It is a broad spectrum, beta-lactamase resistant, carbapenem antibiotic for parenteral administration. It readily penetrates through the cell wall of most gram-positive and gram-negative bacteria ... -
Product Bisoprolol hemifumarate
SCI Pharmtech, Inc. offers a wide range of active pharmaceutical ingredients which includes bisoprolol hemifumarate. Contact us for more information. -
Product Acarbose
Hangzhou Zhongmei Huadong Pharmaceutical provides wide range of pharmaceutical products which includes acarbose. It belongs to active pharmaceutical ingredient category. Contact us for more information. -
Product Montanide™ Range
SEPPIC SA offers a wide range of products which includes montanide™ range. Features: it can used in about 300 clinical trials from phase i to phase iii. Contact us for more information. -
Product Sufentanil
This API is part of the FCC product portfolio and is available for selected markets only
What are Active Pharmaceutical Ingredients (API)?
Drugs are composed of two major components: – Active pharmaceutical ingredient (API), and excipients. APIs vary from drug to drug and are responsible for creating the intended biological, physiological or therapeutic effect within the recipient's (patient's) body. A drug can contain one or more APIs depending on its purpose and the synergistic actions of the APIs.
Active pharmaceutical ingredients (APIs) are the therapeutically active substances or chemical components of drug products (capsules, tablets, syrups, etc.) that produce an intended pharmacological effect.
The APIs within drugs are conveyed into the body through inactive components known as excipients, which usually make up the bulk of the drug. They facilitate the ingestion, absorption, and distribution of the active ingredients. These excipients serve as vehicles and are usually inert or biologically inactive.
Source APIs from our marketplace of 900+ global API manufacturers and 2,500+ API solutions in categories such as Amino Acids, Enzymes, Antibiotics, Antibodies, Sera and Vaccines and more.
What is the purpose of APIs?
APIs are the primary ingredients contained in drugs and medicines. They play a significant role in drug production and produce pharmacological effects within the body. The pharmacological effects produced, directly or indirectly, influence the diagnosis, symptom relief, mitigation, treatment, cure, or prevention of diseases. APIs also modify, correct, or enhance the physiological function and structure of chemicals, cells, tissues, and organs within the body. In simple terms, they make the drug or medicine work.
What is the overall size of the API market?
With the exponential rise in the global population, the growing demand for a therapeutic solution to critical and chronic diseases, change of lifestyle, and the increasing importance of generics globally, the need for active pharmaceutical ingredients has skyrocketed. As a result of these, the API market growth is increasing at a rapid rate.
Based on research, the global active pharmaceutical ingredient market had an estimated value of $168.87 billion in 2019 and is presently worth $ 187.3 billion. However, the global market is expected to grow by the US $ 100 – 120 billion dollars in the next seven years to attain a market value of US $285.5 billion by 2027. The growth of the API market is expected to move at a CAGR of 6.8% during the forecast period.
This research covers growth trends and competitions in significant regions where APIs are actively manufactured and distributed. These regions include Europe, North America, Latin America, Middle and East America (MEA), and Asian Pacific (APAC). Although the majority of API manufacturing companies are located in the United States, others are located in India and China.
How APIs are synthesized?
API synthesis is a complex multi-step process that involves a wide range of chemical processes and reactions of varieties of raw materials by physical and chemical means. Specialized professionals in API manufacturing companies perform the process of active pharmaceutical ingredient synthesis and manufacturing.
APIs can be synthesized through 3 major processes – Biological process, organic chemical synthesis, and extraction from a biological source. The method used depends on the raw material involved, steps of the process, and complexity of the API molecule.
What steps are involved in the synthesis of APIs?
APIs are tiny complex molecules produced through a variety of processes. The complexity of the active pharmaceutical ingredient to be synthesized plays a significant role in determining the process used and the steps involved in the process. The steps involved in each of the three processes vary. Synthesis of APIs through biological processes include inoculum and seed preparation, fermentation, and product recovery.
Organic chemical synthesis of APIs involves the use of organic and inorganic chemicals and reactors to produce APIs. This process usually consists of the production of intermediates during chemical reactions. In some cases, these intermediates can be used to produce different APIs or used as a separate pharmaceutical entity. Extraction of APIs from a biological source involves passing natural materials through batch processes to extract or produce a pharmacologically active substance.
Although the stages involved in the various processes differ, they are all grouped into different stages - the introduction of raw materials, production of intermediates, isolation, and purification, and physical processing and packaging.
Given that technology is continually evolving, continuous flow-system has been introduced to enhance the API synthesis and manufacturing process.
How long does it take to synthesize APIs?
The length of the manufacturing process is majorly dependent on the complexity of the API molecule to be synthesized and the process used. API synthesis is a long and complicated process that may take months and sometimes, up to years to complete. The complexity of the structure influences the API synthesis period length, the number of steps in the synthesis route, type of synthesis, cost of the process, drug impurities present, number of APIs to be produced, and the number of isolation steps involved.
What is the goal behind the synthesis of APIs?
API synthesis facilitates the processing and manufacturing of pure pharmaceutical preparations (APIs) for clinical use. Through API synthesis, these active ingredients are extracted, purified, and packaged for treatment, diagnosis, cure, mitigation, and prevention of diseases. These APIs are synthesized and manufactured into biologically secure forms and substances to produce specific pharmacological effects within the recipient's body. Simply put, the primary goal of API synthesis is to create pure, potent, and safe APIs for drug development and production and administration to patients.
Challenges with API reactions and drug interactions
APIs make up the primary ingredients within drugs and are mostly responsible for drug-drug interactions. These drug-drug reactions constitute one of the major causes of failed treatment in patients as well as the production of adverse drug effects in them. Also, reactions of APIs combined within the same drug pose a significant challenge to API manufacturers and the healthcare industry.
How do API and drug interactions occur?
API and drug interactions usually occur as a result of poly-therapy, and this is mostly seen amongst elderly patients. With poly-therapy, the API of one drug interferes with the pharmacological activity of another, by enhancing or inhibiting the function of the other. These reactions usually result in diverse severe health implications and some scenarios, death. This interaction is significantly influenced by the pharmacodynamics of the body and the pharmacokinetics of the drug.
API and drug interaction can either occur during absorption, distribution, metabolism, or excretion of the drugs. Co-administration of drugs (polytherapy) greatly influences the body's response to them, and the risk of API and drug interaction rises as the number of medications administered increases. These reactions are why the API of drugs is taken into consideration when administering several drugs at once or concomitantly.
How does drug data sharing work?
The increasing need for transparency between research participants, publishers, research funders, pharmaceutical companies, regulating bodies, and trading companies during clinical trials has heightened the demand for drug data sharing. Though not yet fully established in some countries, several data sharing policies and guidelines have been set up to support this movement.
Through drug data sharing, clinical results, data, and clinical trial practices are shared and made available to pharmaceutical companies, research investigators, institutions, and other sectors to improve public health, drug development, and boost patient safety. Clinical data is shared at participant and company-level to improve company practices and public trust.
How do you set up the testing parameters of API reactions?
API testing ensures the production of stable and quality active pharmaceutical ingredients. The strength, quality, and stability of APIs are assessed by the manufacturers and regulating agencies through specific standards. Although this is done for all APIs, the testing parameters set up will vary based on the API and the brand. The primary test carried out is the stability test, and it includes stress-testing, storage conditions testing frequency, container closure system, specification, and selection of batches.
The quality of an API is directly proportional to the potency, efficacy, and safety of the medication. Low quality and compromised APIs harm the recipient's health. To ensure the production of high-quality and stable APIs, pharmaceutical companies are only allowed to handle one or two stages of the drug production process. Also, outsourced APIs and locally produced APIs and medications are thoroughly screened and tested to ensure the quality and safety of drugs.
What role does an API manufacturer play in pharmaceutical research?
The API manufacturers constitute a significant part of the pharmaceutical company globally, as well as the healthcare industry. They help to improve and facilitate pharmaceutical research in many ways. API manufacturers play a significant role in pharmaceutical research by conducting research and providing fact-based data and results on APIs and their pharmacological effects on the body.
Through in-depth analysis and a combination of efforts and contributions from active pharmaceutical ingredients manufacturers and other professionals in the pharmaceutical industry, potent and safer drugs can be developed to improve healthcare delivery.
What are the key market trends in API manufacturing?
The global demand for active pharmaceutical ingredients is on the rise, and there are a variety of factors that have actively contributed to its growth. Some of the key trends driving the development of the global active pharmaceutical ingredient market and API manufacturing include the worldwide rise of chronic diseases as well as the increasing demand for and importance of generics. Over the years, there's been a growing prevalence of chronic diseases such as chronic obstructive pulmonary disease (COPD), arthritis, hepatitis, cancer, etc., in various parts of the world.
The rapid rise of these diseases can be attributed to the increase in the geriatric population across the world. With this population experiencing a lifestyle change, and dietary consumption as a result of urbanization, an increase in the occurrence of chronic diseases such as cancer, is expected. This, in turn, will affect demand, as well as positively influence the market.
Also, as a result of technological advancement in active pharmaceutical ingredient manufacturing, the global API market is taking a huge turn around. Besides, another key trend that has positively influenced the market is the increased use of artificial intelligence-based drug discovery and production.
Market trends that have negatively influenced the global API manufacturing market include the cost of drug monitoring in other countries, intense competition between API manufacturers, and increasing production of anti-counterfeit drugs. The major market trend that has negatively influenced the market is the high cost of manufacturing APIs and unfavourable drug pricing control policies in countries across the world.
What are the key players in the active pharmaceutical ingredients market?
There are several competitor pharmaceutical companies working in the global active pharmaceutical ingredients market. These API manufacturing companies have contributed a great deal to the growth of the global API market. Some of the prominent and leading API companies include:
- Pfizer Inc. (US),
- TAPI (Teva Active Pharmaceutical Ingredients Israel),
- Sun Pharmaceutical Industries Ltd. (India),
- Aurobindo (India),
- Novartis International AG (Switzerland),
- Boehringer Ingelheim (Germany),
- Abbott (US),
- AbbVie (US),
- GlaxoSmithKline Plc (UK),
- Merck &Co. Inc. (US) amongst many others.
Regardless of these strategies, these key players in the global API market are still likely to face tough competition from new and upcoming companies in the industry.
References
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