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CPHI Online is the largest global marketplace in the pharma ingredients industry
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APIs (Active Pharmaceutical Ingredients)
APIs (Active Pharmaceutical Ingredients) Companies (500+)
APIs (Active Pharmaceutical Ingredients) News
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News Pharma Supply Chain People Moves
The latest appointments and promotions across the pharmaceutical supply chain.1 Jul 2022 -
News WuXi STA launches new HPAPI production facility in China
The new plant features flow chemistry and milling technology, as well as reactors up to 3,000 liters1 Jul 2022 -
News Supply chain disruptions continue, but is the end in sight?
Supply chain disruptions have become the new normal. Recurring pandemic waves, inflation, trade jitters and a war in Europe have done little to quell C-suite anxieties.28 Apr 2022 -
News Onyx Scientific expands small molecule CMC services with new UK facility
The contract development and manufacturing organisation (CDMO) has completed the first phase of its multi-million-pound development.28 Apr 2022 -
News Bora Pharmaceuticals invests $10M to expand oral solid dose capabilities at two sites
The investment will expand operations over two years at facilities in Taiwan and Canada21 Apr 2022 -
News CPHI North America Lookahead: Facilitating ‘meaningful conversations’ on needs and solutions
CPHI NA takes place as a SMART event this year, with online learning and networking from May 9-27 and an in-person event from May 17-19 in Philadelphia, PA.19 Apr 2022 -
News Celebrating World Water Day and the PSCI’s continued support for the Musi River Revitalisation Initiative
The Musi River flows through Hyderabad in Telangana State, southern India. It is fed by the world heritage Hussain Sagar Lake, known as the 'heart of the world'.14 Apr 2022 -
News Drugmakers pledge faster, more equitable medicine access in Europe
Drugmakers have agreed to speed up the market launch of new drugs in underserved EU member states as an alternative to stricter regulation.11 Apr 2022 -
News AGC Pharma Chemicals to boost capacity by 30% at Spanish site
The expansion will increase production capacity for synthetic pharmaceutical products8 Apr 2022 -
News Sanofi to list drug ingredients subsidiary EUROAPI on Euronext Paris
Sanofi will reduce its stake in EUROAPI to 30% after listing4 Apr 2022 -
News Janssen invests €150M to expand Irish biopharmaceutical facility
The expansion will take two years and add 180 new jobs.25 Mar 2022 -
News Boom expected in global COVID-19 drug associated APIs market
Market set to grow as companies face fewer operational restrictions and COVID-19 drug development continues at pace23 Mar 2022 -
News Seqens commits to US market with multi-million dollar investment in R&D
A redeveloped R&D facility will enhance Seqens' capabilities in developing and producing APIs and active delivery systems development23 Mar 2022 -
News Lonza scoops contract to manufacture ovarian drug candidate for Oasmia
The CDMO will produce drug substance for clinical supply at its HPAPI manufacturing site in Nansha, China21 Mar 2022 -
News KKR-backed Biosynth Carbosynth acquires Vivitide
KKR closes its previously-announced acquisition of Biosynth Carbosynth and announces Biosynth's acquisition of vivitide.18 Mar 2022 -
News Lonza adds HPAPI manufacturing capabilities to its Nansha, China site
The development and cGMP manufacturing laboratories will provide additional early-phase HPAPI manufacturing capabilities8 Mar 2022 -
News HCmed to expand inhalation treatment business with new CDMO offering
The Taiwan-based nebuliser specialist has signed an MoU with Formosa Laboratories, and Formosa Pharmaceuticals to form a biopharma one-stop-shop7 Mar 2022 -
News Hovione and Zerion Pharma collaborate to commercialise low drug solubility solution
By joining forces, the two companies will be able to bring Dispersome to the market faster for novel drug development22 Feb 2022 -
News Steps for Building Supply Chain Integrity and Resilience in Europe
Speakers from the European Fine Chemicals Group, the voice of fine chemical manufacturers in Europe, led a discussion on the ‘globalised, fragmented and complex’ API and raw materials supply chain, in this month’s edition of the CPHI ...2 Feb 2022 -
News UPDATED: COVID-19 Pharma Development Tracker
The latest coronavirus updates and developments impacting the global pharmaceutical supply chain6 Jul 2022
APIs (Active Pharmaceutical Ingredients) Products (1000+)
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Product APIs
Recipharm operate facilities which can manufacture several products at a time, handling high pressure, high temperature (up to 150 degrees Celsius) and low temperature (down to –80 degrees Celsius) reactions. Different batch sizes are available ranging from 20L to 6000L, supporting early development and comme... -
Product Inhalation Product Analysis and Testing
Inhalation product analysis and testing services include particle size and droplet characterization, delivered dose testing, as well as aerodynamic particle size analysis – for pressurized metered-dose inhalers (PMDI), dry powder inhalers (DPI), nebulizers, and soft mist inhalers. Our Good Manufacturing P... -
Product Active Pharmaceutical Ingredients and Intermediates
We provide customized chemical synthesis for active pharmaceutical ingredients from concept to commercial supply.
We are an industry-leading integrated development and manufacturing service provider for small molecule drug substances and their intermediates.
Chemistry is core... -
Product Polyglykol
Effective and high-purity ingredients including a complete range of Polyglykols (Macrogols) our universally applicable pharmaceutical polymers, with various molecular weights, supported by CEP certification and DMF type II documentation. -
Product Paclitaxel API
Phyton commercially supplies paclitaxel API (from Plant Cell Fermentation PCF™). It is inspected by: USP/EP, CEP 2011-324, US DMF 25525, filed in Japan, Korea, China, India. Contact us for more information. -
Product CARBOWAX™ SENTRY™ Polyethylene Glycol (PEG)
CARBOWAX™ SENTRY™ PEGs common applications include: carrier/plasticizer in gel capsules, base for face/neck lotions, providing formulation stability in toothpaste, binder for tablets, shampoo wetting agent, and more. CARBOWAX™ SENTRY™ PEGs are available in average molecular weights ranging from 300 ... -
Product Active Pharmaceutical Ingredients
We cover the spectrum from clinical to commercial services to outsource active pharmaceutical ingredients (APIs), registered intermediates (RIs), and registered starting materials (RSMs). DSM services encompass most commercially-used chemical conversions. Some of our specialities include:
•Chiral techn... -
Product Flurbiprofen,
Azilsartan,
Epalrestat,
Fimasartan,
Flurbiprofen,
Loxoprofen Sodium,
Nizatidine,
(3-Carboxypropyl)triphenylphosphonium bromide,
(methyl 2-ethoxy-1-((2'-(5-oxo-4,5-dihydro-1,2,4-oxadiazol-3-yl)-[1,1'-biphe... -
Product Sodium Hyaluronate Hyaluronsan HA-AM
Sodium Hyaluronate (API): MW 600 - 1,200 kDa Certificates: GMP certified sodium hyaluronate powder extracted from chicken comb, DMF in Japan, USA, China and South Korea
Application: Used in the pharmaceutical preparations for knee-osteoarthritis injection, (d... -
Product Vinpocetine
VINPOCETINE ORAL GRADESemi-synthetic derivativeSuitable for oral pharmaceutical forms.
VINJECT
Semi-synthetic derivative - Suitable for injectable pharmaceutical forms
PHARMA USE
Cerebrovascular disorders
Degenerative senile cerebral dysfunction
Peripheral vasodilatation an... -
Product Sodium oxybate
Johnson matthey pharma services offers a wide range of products which includes sodium oxybate. Features: it is used in cns depressant (narcolepsy). Contact us for more information. -
Product Butorphanol Tartrate
Butorphanol Tartate is a morphinan-type synthetic opioid analgesic.
It is approved by NMPA. -
Product Diosgenin
Diosgenin (CAS NO.512-04-9) is an important basic raw material for producing steroid hormones or steroidal sapogenin drugs. Steroid hormones have strong anti-infection, anti-allergic, anti-viral, and anti-shock pharmacological effects, and are important drugs for the treatment of rheumatism, cardiovascul... -
Product Manidipine Hydrochloride
Manidipine Hydrochloride,Manidipine,Manidipine HCl,cas#89226-75-5
Used to prepare related preparations of manidipine hydrochloride for treating hypertension. -
Product Crotamiton (CEP)
Transo-Pharm Handels-GmbH offers a wide range of API products which includes Crotamiton (CEP). It belongs to API category. Contact us for more information. -
Product 7-ADCA
7-Aminodesacetoxycephalosporanic acid is used in the synthesis of cephalosporins and for bioconversion studies . Biochem/physiol Actions 7-ADCA is produced from penicillin G made by Penicill... -
Product APIs & Intermediates
We leverage our experience in everything – from R&D to process innovation to navigating the complex global regulatory arena – to help clients efficiently develop and manufacture quality products • Small Molecules
• Carbapenems
• Glycans
• Peptides
... -
Product Amygdalin
Shaanxi Jiahe Phytochem Co Ltd offers a wide range of products which includes amygdalin. It belongs to ingredients category. It is a glycoside initially isolated from the seeds of the tree prunus dulcis, also known as bitter almonds, by pierre-jean robiquet and a. F. Boutron charlard in 1830. Several other re... -
Product RoSS®: Protecting single-use bags
Protect your preferred single-use bioprocess containers: RoSS shells - abbreviated for Robust Storage and Shipping - reduce product loss towards 0%. Compatible with all available sizes and types of single-use bags, RoSS enables standardized and scalable end-to-end process solutions for fluid management a... -
Product S.boulardii
Patented and clinically substantiated yeast probiotic S.boulardii strain to help manage diarrhea and restore the gut flora balance. S.boulardii, the physicians' solutions for decades to support a healthy gut. -
Product API and advanced intermedates development and manufacturing
With our global standard quality system, we are uniquely positioned to be your strategic manufacturing partner for reliable, cost effective long-term supplies of your intermediates and APIs from a few grams to metric tons. Our unique"end-to-end" platform ensures knowledge retention throughout your product lif... -
Product Calcium Levomefolate
Active Pharmaceutical Ingredient (6S)-5-Methyl-tetrahydrofolic Acid Calcium Salt is used as a food supplement for folate deficiency and also in cases of depression disorders.
6S)-5-Methyl-tetrahydrofolic Acid Calcium Salt is the isomerically pure form of 5-Methyl-tetrahydrofolic, Acid Calcium Salt.... -
Product Lab reactor
The Steroglass lab reactor comes from an innovative reaction concept made with the same materials used in the chemical process. Ideal for scale down and scale up processes, it guarantees a quick return on investment for your research projects.The Steroglass Lab reactor has a stainless steel support structure ... -
Product Omeprazole Sodium Sterile (Lyohilized)
Omeprazole sodium sterile belongs to a class of drugs known as proton pump inhibitors (PPIs). This vaccination is a compound of omeprazole and sodium hydrogen carbonate. It is used to treat the certain abdomen and esophagus problems (such as acid reflux, ulcers). It is also used to prevent abdomen interna... -
Product API Pharmaceutical Plants and Equipment - Used Equipment and Complete Sites Available
IPP has available complete pharmaceutical plants that can be operated in place as well as relocation.
We have recently acquired pharmaceutical systems in both API and Formulation that can be moved to your plant site saving your projects 50-60% of the equipment value versus new. You can also save 85... -
Product Acepromazine maleate [vet]
WELDING GmbH & Co. KG founded in 1955, independent, family-owned. Global marketing, sourcing and distribution of APIs for human and veterinary medicines, additives for the food and feed industry.
Development of finished products, including services related to IP evaluation, regulatory affairs as ... -
Product Homatropine Methylbromide
Anzen Exports provides wide range of pharmaceutical products which includes Homatropine Methylbromide. It belongs to active pharmaceutical ingredients category. Contact us for more information.
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Product Analgesics
Sintetica SA offers wide range of products which includes analgesics. Contact us for more information. -
Product Aluminium chloride-6-hydrate
Cg Chemikalien Gmbh & Co Kg offers wide range of api and excipients which includes aluminium chloride-6-hydrate. Contact us for more information. -
Product Active Pharmaceutical Ingredients
Smart Ingredients offers a wide range of APIs which are manufactured in compliance with standards of Good
Manufacturing Practices (GMP) and appropriate regulatory frameworks (CEP, DMF, etc.). Along with our experienced technical Teams, we exceed your expectations with class-leading service, support, an... -
Product 2-Phenoxyethanol Multi- Compendial API grade
A&C Your Global GMP Partner offers a wide range of products which includes 2-phenoxyethanol multi-compendial API grade. Contact us for more information. -
Product Polysorbate 80 / Hedisan-80 (API)
Hedisan-80 is a high quality Polysorbate 80. The product is produced at Kolb in Hedingen. The site has been authorised by SwissMedic to manufacture and distribute active pharmaceutical ingredients and is subject to regular GMP inspections. Kolb has a broad portfolio of non-ionic surfactants with po... -
Product Bedrocan - THC 22% | CBD <1.0%
Introduced in 2003, Bedrocan® is the brand name for the cultivar Cannabis sativa L. ‘Afina’. Cannabis sativa L. ‘Afina’ is the first cultivar developed and it features 22% THC, with a CBD-level below 1%. It’s the most widely used medicinal cannabis product and has been used i... -
Product R&D Service
1. Process R&D
1) Synthetic route scouting
2) Process Optimization
3) Impurities fate/purge study
4) Control strategy: PAR & DOE
5) Technology trasnfer
6) Procative trouble shooting
7) N... -
Product TETRACYCLINE HYDROCHLORIDE
specifications:USP/ EP/IP/BP
Packing: 25Kgs/ Carton
Certifications: Manufacturing license, EU-GMP,Indian DCGI approval,Pending approval by U.S.FDA, COS application in progress.
Product Advantages:
... -
Product APIs (Flavonoids)
Venotonics for chronicle treatment of CVD, varicose veins, hemorrhoids, spider veins, and heavy legs syndrome. Promotes blood circulation and addresses vascular discomfort:
• Diosmin (CEP & DMF). HTBA is the world’s largest producer of Diosmin. IP: Solvent-Free method GMP. • Hesperidin (... -
Product CDMO Services
Strong R&D with over 100 patents filled and 4 cGMP manufacturing sites offering from pre-clinical to commercial supplies (from grams to multi-tons).
With available capacity to start supporting your project now! -
Product FlowChem Platform
Angelini Fine Chemicals is one of the first European CDMOs investing in flow chemistry and micro-reaction technology for development and manufacturing of APIs and HPAPIs. Angelini Fine Chemicals brings extensive experience in research and development of flow continuous process and offers extensive custom d... -
Product Curculigo Orchioides Extract
• Name- Curculigo Orchioides Extract • Specifications- Curculigosides 25% to 35% (By HPLC) • Application- Aphrodisiac /Sports Supplements • Botanical Source- Curculigo Orchioides Roots • Trademark- Rhizome K For more information, please visit our website www.chereso.net -
Product Cabergoline IP/USP/EP
Global calcium manufactures wide range of pharmaceutical products which includes anhydrous magnesium citrate bp. It belongs to magnesium products category. It is a white or almost white, fine, slightly hygroscopic powder. It is soluble in water, practically insoluble in ethanol (96 %). It dissolves in dil. Hc... -
Product Pactol Cough Adults
MASENZ DANYA GROUP SL offers a wide range of products which includes pactol antitussif (adult). Contact us for more information. -
Product Sodium Hyaluronate (Hyaluronic Acid API): MW 250-2300 kDa
Sodium Hyaluronate (Hyaluronan, HA) - TYPE I: MW 250 - 2300 kDa
Ultra-Pure HA
Pharmaceutical Grade (Injection suitable)Certificates: GMP, CEP, DMF
Our Intrinsic Viscosity is from IV 0.7 to 2.8 m3/Kg
Sodium hyaluronate is a polysaccharide found in... -
Product Digoxin, Digoxin Micronized
C2 PHARMA provides a wide range of active pharmaceutical ingredients (APls) and complex chemical compounds obtained from natural and synthetic origins which includes Digoxin.
C2 PHARMA is the only API manufacturer able to offer a fully redundant dual-source of Digoxin API produced at two d... -
Product Diphenyacetic Acid
Diphenylacetic acid is a monocarboxylic acid that is acetic acid where the methyl hydrogens have been replaced by two phenyl groups respectively. It has a role as a xenobiotic metabolite.
Shree Ganesh Remedies Limited is one of the leading manufacturer and supplier of the Diphenyacetic A... -
Product Aspirin
SEQENS offers wide range of products which includes aspirin. Contact us for more information. -
Product Small Molecules
Our multi-patented Controlled Expansion of Supercritical Solutions (CESS®) technology enables the creation of API nanoparticles directly from solution. The process can be applied to most small molecules, with a high success rate of 80-90%.
CESS® is a bottom-up method of recrystallization that works... -
Product Algal DHA
Algal DHA, a vegetarian, sustainable and highly stable algal Omega-3 DHA produced from the microalgae Schizochytrium. Although fish oil is well known for having a high content of EPA and DHA, micro algae is the original source of marine omega-3. Algal DHA is the DHA in Algal oil that is derived directly from ... -
Product API's (Active Pharmaceutical Ingredients)
Interested in learning more about our API’s (Active Pharmaceutical Ingredients) specialty excipients?
At Barentz we always have a better solution! Reach out to us [email protected], we’d be happy to help!
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Product Amphotericin B
Amphotericin B is a mixture of polyenes active against a wide variety of fungi e.g. Aspergillus, Candida and Cryptococcus species.
Indication: Used in the treatment of severe, invasive, potentially life-threatening fungal infections (mycosis) typically in immunocompromised patients.
... -
Product Colloidal Silver EP / Collargol
Laboratorios Argenol offers wide range of pharmaceutical products which includes Colloidal Silver. Characteristics: green or bluish-black metallic shiny flakes or powder, hygroscopic. Solubility: Freely soluble or soluble in water, practically insoluble in ethanol and methylen chloride. Contact us for more in... -
Product Amisulpride
LEBSA manufactures in compliance with full GMP conditions a range of Active Pharmaceutical Ingredients (APIs) which includes Amisulpride (CAS number 71675-85-9). It is a neuroleptic/ antipsychotic agent manufactured in our unique European GMP manufacturing plant loc... -
Product BAC
Benzalkonium Chloride Ph.Eur., USP/NF (BKC/BAC/BAK) CAS No. 8001-54-5
Consists of Benzyl (dodecyl) dimethyl ammonium chloride (C12 approx. 65%) and Benzyl (tetradecyl) dimethyl ammonium chloride (C14 approx. 35%). Other chain length distributions are also available. Available with more tha... -
Product Heparin sodium
Heparin sodium has been medically important as an anticoagulant since its introduction over a half-century ago, and recently several new biological activities have been assigned to it. Applications: pulmonary embolism; prevention of pulmonary thromboembolism and deep venous thrombosis (also in pregnancy),... -
Product PHSE UK
• Specialty courier dedicated to clinical trials and the drug development process • Import and export from more than 70 countries including 3rd country and direct to site 24hr operations 7 days per week, 365 days per year • Walk in cold chain facilities for high volume supply of temperature controlle... -
Product Diminazene Aceturate
NGL Fine-Chem Ltd manufacturers wide range of pharmaceutical products which includes Diminazene Aceturate. It belongs to API's animal health products category. It is a lemon yellow powder, odorless. Therapeutic Category : Antiprotozoal Contact us for more information. -
Product inline mixer CMX with 2 dispersing stages
The IKA CMX 2000 is an inline mixer for rapid and homogeneous incorporation of powders into liquids. The circulation of fluid creates a powerful vacuum in the machine that draws in the powder. This ensures an agglomerate free integration of problematic powders that are not easily incorporated into the liquid ... -
Product Basalin®(insulin glargine injection)
Basalin® is an insulin glargine injection developed and produced independently by Gan & Lee Pharmaceuticals. It was launched in China in 2005 and has been approved in almost 20 countries globally. As a long-acting biosimilar insulin, Basalin® is able to stablely control human blood sugar within 24 ho... -
Product Drug Substances
With more than 30 years of experience in Pharma, Midas has demonstrated a proven track record & expertise in sourcing and supplying Drug Substances (APIs) required for the pharmaceutical production. We work closely with our manufacturing partners around the globe and are active in more than 700 drug ... -
Product Manufacturing
Custom API Manufacturing, Fermentation, Finished Dosage Form, High Potency, Lipid Nanoparticle, Rare / Orphan, Stability & Release Testing, Sterile Fill Finish, APIs & Intermediates, Fine Chemicals
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Product Custom API
AbbVie’s API site has the flexibility to run multiple chemical processes simultaneously to support late development phase to commercial products including highly potent drug containment up to OEL 3A (1 µg/m3). State of the art QC laboratories integrated across a highly experienced team focused on commercial r... -
Product Active Pharmaceutical Ingredients
OLON is an Italian company world leader in the Active Pharmaceutical Ingredients (APIs) production, using synthetic and biological processes for Generic market as well as in Contract Development and Manufacturing (CDMO).
Always considering human safety and environmental security, OLON handles... -
Product Gaskets for pharmaceutical applications
Dockweiler gaskets ensure the availability of various materials from approved high quality vendors to complete our high quality product range of tubular components. Dockweiler guarantees total traceabilty even for gaskets: laser engraved, lipped gaskets with material certification. Dockweiler gaskets are clea... -
Product Early Phase Support
From the lab to the plant:• Development of new, scalable API route options
• Process safety and hazards assessment
• cGMP starting material assessment& establishment of regulatory concept
• Starting material & other raw materials sourcing and development
• Polymorph screening & salt se... -
Product Kijimea® Synpro 20
Kijimea® Synpro 20 is a dietary supplement containing 20 selected microcultures that occur in the natural intestinal flora of humans. In addition, Kijimea® Synpro 20 contains choline, FOS, inulin and biotin, which helps to maintain normal mucous membranes.
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Product CordenPharma Peptides Platform
Your Expert Partner for Peptide APIs
• >> Proven track record delivering world class manufacturing services from early stage to commercial supply, including complex products (e.g., Linaclotide, Enfuvirtide, Mifamurtide, Eptifibatide, Glatiramer, GLP analogues). • >> Proprietary pr... -
Product Azithromycin Taste Masked Granular Powder
White to off white tasteless free flowing granules
Recommended for Dry Syrup / Suspension
Available Acitivies are 22.22% & 26% -
Product Chlorthalidone
CAS Number: 77-36-1
Formula: C14H11ClN2O4S
Molecular Weight: 338.8
API
Aplication: Diuretic - Hypertension treatment
DMF, CEP, KFDA, GMP, USDMF
www.menadiona.com
[email protected] -
Product Celecoxib (Form III)
PharmaZell GmbH manufactures a wide range of commercial API's which includes Celecoxib (Form III). Therapeutic area: NSAID. Pack size [kg]: 25. Grades: Standard, micronized, fine. Regulatory Documentation: CEP, EU DMF, US DMF. Contact us for more information. -
Product NORMOBOWELL
Medical Device for the management of Irritable Bowel Syndrome.
MEDICAL DEVICE CE 0477 CLASS IIB -
Product Ectoine, (S)-2-Methyl-1,4,5,6-tetrahydropyrimidine-4-carboxylic acid
VIO Chemicals offers a broad range of APIs through its wholly-owned subsidiary in Greece, VIO AG Pharmaceuticals S.A. VIO Chemicals is currently developing Ectoine. Products which are subject to patent protection are currently not offered or made available in Germany and in countries where patents are in ... -
Product Triptorelin Acetate
Product Name:Triptorelin Acetate;Cas No. 57773-63-4;Sequence Pyr-His-Trp-Ser-Tyr-D-Trp-Leu-Arg-Pro-Gly-NH2;Molecular Formula C64H82N18O13;Molar Mass 1311.5 g/mol;Purity ≥98%;Impurity ≤0.5% ;Storage Temperature 2-8℃;Packing Size 1G/Bottle, 10G/Bottle,50G/Bottle or at customers reqirement.
Triptorelin Acetat... -
Product Antazoline Hydrochloride
Fields of Application: Conjunctivitis. Antazoline Hydrochloride is an ethylenediamine derivative with antihistaminic properties and is used in conjunction with a vasoconstrictor for ocular allergies. -
Product API PORTFOLIO
Hovione's APIs offer impeccable chemical purity and unique product performance.
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Product Land in Europe- EU Market Access Support Services
Azierta provides global support in accesing to European Market to Non-European companies
European Pharma market access support services: There are three main strategies that may be implemented on an individual basis, or alongside each other, depending on your company needs, i... -
Product Pharmacopea Analysis
Neotron SpA provides wide range of analytical control according to EP, USP, JP, BP, CHP.
Contact us to ask for tests in relation to your monograph of interest. -
Product Oxacillin sodium
Reyoung Pharmaceutical Co. Ltd. is one of the leading manufacturer and distributor of pharmaceutical products.
It has 31 workshops, which can produce ten categories and more than 400 specifications of pharmaceutical products including tablets, capsules, granules, st... -
Product Active pharmaceutical ingredients services
Taking advantage of our global presence with offices located in all the key areas for the chemical and pharmaceutical business, Summit Pharmaceuticals Europe can provide a large range of different APIs.
Due to our long experience and consolidated relationships with our partners we can provide material from... -
Product Sunvidone ® PI Solution
SUNVIDONE PIS is a deep-brown solution of Sunvidone PI in water. They are stablebroad spectrum and non-selective germicidal antiseptics and disinfectant which havedetoxified iodine, no general odor, no loss of iodine, no detectable vapor pressure. They arewater soluble, Film-forming and effective in dilute so... -
Product Contract Manufacturing Solutions
GVK BIO offers long term Contract Manufacturing Solutions in development, validations, DMF filing, manufacturing of New Chemical Entities (NCE), Active Pharmaceutical Ingredients (API) and Intermediates.
Capabilities:Environment friendly routes under GMP conditions
Robust and cost-effective proc... -
Product Nitrosamine Impurities Testing
SGS Life Sciences has considerable expertise in the method development of nitrosamine determination in pharmaceutical products. SGS has established a specific method for NDMA which can be applied to various different matrices. Alternatively, a platform method, based on trace-level detection by LC-MSMS, is als... -
Product Mexiletine hydrochloride
Active Pharmaceutical Ingredient. Arrhythmia indication. Cardiovascular therapeutic area. -
Product Amantadine hcl
Moehs Fine Chemicals provides a wide range of generics which includes amantadine hcl manufactured under GMP guidelines. FDA approved site. It belongs to antiviral - antiparkinsonian category.CEP, EDMF, USDMF Packaging: Fiber drum 40 Kg Product manufactured in regular basis. Contact us for more inf... -
Product POVIDONE, MICROCRYSTALLINE CELLULOSE, HYPROMELLOSE, CROSPOVIDONE, COPOVIDONE, CCS, COLLOIDAL MCC, LACTOSE, STARCH, SUCRALOSE, SACCHARIN, CYCLODEXTRINS, POLOXAMER, POLYSORBATE, PEG, API, INTERMEDIATES, FILTER BAGS, SILICA, SILICONES,
DILUENTS, BINDERS, DISINTEGRANTS, FILM FORMERS, PLASTICIZER, POLYMERS, SWEETENERS, SURFACTANTS, PEPTIDES, OMEGA 3 FATTY ACID, VITAMINS, DIETARY FIBRES, COCOA POWDER, ANTI AGEING, ANTI WRINKLES, MOISTURIZERS, ENCAPSULATED BEADS, SCRUBING BEADS, -
Product Thermo Compression distillation system/ Vapour Compression distillation system
Thermo Compression distillation system is the most economical method of producing highest quality WFI. The system is available in wide range of production capacities, from 100 LPH to 5000 LPH. The system is fully automated, in compliance with GAMP5 standards and is also available to comply with 21 CF... -
Product HRS Hot Water Systems
HRS Hot Water System is the most versatile and compact solution offered by HRS Process Systems Ltd. for hot water generation. It generates instantaneous hot water using energy efficient heat exchangers like HRS Funke Brazed or Gasketed plate heat exchanger or Ecoflux* corrugated tube heat exchan... -
Product Fomepizole
An orphan drug API used in its finished form (injectable) is the only known antidote for methanol and ethylene glycol poisoning in the world. Available for all global markets along with DMF support.
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Product Hydrochlorothiazide
Hydrochlorothiazide is a benzothiadiazine that is 3,4-dihydro-2H-1,2,4-benzothiadiazine 1,1-dioxidesubstituted by a chloro group at position 6 and a sulfonamide at 7. It is diuretic used for the treatment of hypertension and congestive heart failure. It has a role as a xenobiotic, an ... -
Product Active pharmaceutical ingredients (APIs)
High quality APIs to accelerate your generic product launches. Catering to leading innovator and generic companies across the world, Dr. Reddy’s is recognized as one of the largest API suppliers worldwide. The launch of Dr. Reddy’s XCEED – a digital customer service platform - gives customers instant... -
Product Hyatrue® — Pharmaceutical Grade Sodium Hyaluronate
Hyatrue® is a pharmaceutical grade sodium hyaluronate which can be used as an API or excipient for drugs and medical devices in ophthalmic preparations, intra-articular injections, anti-adhesive preparations, topical preparations for wound healing and soft tissue filler, etc. Hyatrue® sodium hyaluronate is ... -
Product Acyclovir 400 Mg Tablet
Pharmaniaga Manufacturing Berhad provides wide range of pharmaceutical products which includes acyclovir 400 mg tablet. Packaging: pack of 50 x 10's. Contact us for more information. -
Product CEREBROLYSIN®
EVER Neuro Pharma GmbH offers a wide range of products which includes CEREBROLYSIN®. It is a biotechnologically prepared peptide that stimulates neurotrophic regulation in the central nervous system. It is used worldwide for treatment of ischemic and hemorrhagic stroke, traumatic brain injuries, to treat diff... -
Product Hyacyst
Sodium Hyaluronate Solution for the treatment of interstitial cystitis Intracavital instilation -
Product Ethacrynate Sodium
Etacrynic acid (INN) or ethacrynic acid (USAN), trade name Edecrin, is a loop diuretic used to treat high blood pressure and the swelling caused by diseases like congestive heart failure, liver failure, and kidney failure.
Biophore's Ethacrynate Sodium :
US DMF Available -
Product Amitraz
Synonyms : 1,5-di(2,4-dimethylphenyl)-3-methyl-1,3,5-triazapenta-1,4-diene; Methyl-bis(2,4-xylyliminomethyl)amine
CAS No. :33089-61-1
Molecular Formular : C19H23N3
Molecular Weight : 293.41
Appearance : white needle crystal
Melting Point : 86-87oC
Solubility : Soluble in acetone, xylene, met... -
Product RIFAXIMIN BY FRIULCHEM - Human and Veterinary use
RIFAXIMIN BY FRIULCHEM FOR HUMAN USE
Rifaximin is approved for the treatment of travellers’ diarrhoea in adults and children 12-years of age and older. Rifaximin has also been evaluated for the treatment of hepatic encephalopathy, infectious diarrhoea, diverticular disease and as an antibacterial ... -
Product Aprepitant
Pharmaceutical form: Hard Capsules. Therapeutic category: Prevention of nausea and vomiting associated with moderately emetogenic cancer chemotherapy in adults.
Strengths: 40mg, 80mg, 125mg, 165mg (Not available in the US market).
Contact us for more information.
Produ... -
Product Lactulose Liquid API
With 40 years of expertise in Lactulose production, highest quality standards and a second Lactulose plant in Italy, we rank among the leading global Lactulose producers. We supply liquid Lactulose as bulk API in 250 kg drums or 1.250 kg containers. Our plant is cGMP- and ISO-certified.
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Product Acebutolol hydrochloride
Sanofi Cepia offers a wide range of products which includes acebutolol hydrochloride. Therapeutic class: beta blocking agents. Contact us for more information. -
Product Active Pharmaceutical Ingredients (APIs)
Citric Acid AnhydrousTripotassium Citrate Monohydrate
Trimagnesium Citrate Anhydrous
Trisodium Citrate Dihydrate
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Product Hydrochlorothiazide
Therapeutic Area: Cardiovascular system • EU DMF available • US DMF no. 17599 available • Japanese DMF available • CEP available
Indication: Hydrochlorothiazide is a diuretic drug of the thiazide class that acts by inhibiting the kidneys' ability to retain water. This reduces the volume o... -
Product WATER RING VACUUM PUMP
We have pleasure in introducing ourselves as one of the leading manufacturers of Vacuum Pumps. Now, we would like to give our short introduction as under.(1) We are manufacturing Liquid Ring Vacuum Pumps and Twin Lobe Roots Blowers in India since last 38 years.
(2) We have very wide product r... -
Product Biotage® Flash 400 Systems
The ultimate purification system, Isolate up to 8 kg of product per run at 6 L/minThe Biotage® Flash 400 system is a complete skid-mounted system designed for kilogram scale separations. Built to last and engineered with high quality materials that comply with various cGMP standards. Available in two co... -
Product LABEL INSPECTION
The system snaps 2 lateral (transversal) images as bottles pass through the inspection enclosure especially for oriented rectangular, triangular and oval containers. The inspection system is placed outside labeller over conveyor. Complete turnkey installation for inspection of missing labels, upside down labe... -
Product Balsalazide Disodium Dihydrate
Formosa Laboratories provides a wide range of active pharmaceutical ingredients which includes balsalazide. It belongs to anti-inflammatory and analgesic agents category. Contact us for more information. -
Product Sodium Hyaluronate (HA)
Miat offers Sodium Hyaluronate (i.e. HA) obtained by fermentation from Streptococcus equi subsp. Zooepidemicus, intended for Pharmaceutical (available IV range 0.6-3.6 m3/kg) and Medical Device use (available IV range 0.1-3.6 m3/kg). The offered HA is supported by European documentation i.e. the CEP... -
Product Pharmaceuticals (active pharmaceutical ingredients [APIs]
NAGASE (Europa) GmbH offers wide range of products which includes Pharmaceuticals (active pharmaceutical ingredients [APIs]. It deals in a wide range of products, including raw pharmaceuticals and intermediates, as well as injection drugs for company. Contact us for more information. -
Product Chenodeoxycholic Acid or Chenodiol
ICE S.p.A provides a wide range of products which includes chenodeoxycholic acid or chenodiol. It is a natural substance found in human bile. it's used in the treatment of gall stones disease and it's obtained by synthesis starting from cholic acid. it's used as intermediate for ursodeoxycholic acid manufactu... -
Product Octenidine Dihydrochloride
Purity min. 99,7% (HPLC)Free of N,N-Dimethylformamide, o-Xylene, Methanol, Dimethylacetamide and EthylacetateManufactured according to EU GMP standard, Part II -
Product Vitamin D2
Synthesia a.s. offers a wide range of products which includes vitamin d2. Features: it plays a greater role in health and may protect against numerous forms of cancer, heart disease, diabetes, multiple sclerosis, rheumatoid arthritis and gum disease. Contact us for more information. -
Product Ascorbyl Palmitate
Jiangxi Tianxin Pharmaceutical Co. Ltd offers a wide range of products which includes ascorbyl palmitate. It belongs to vitamin and derivatives category. Generally used as a nutrition reinforcer and antioxidant and antistaling agent. It is widely used in food and beverage industry. Packaging: 20 kg per cardbo... -
Product IRON SUCROSE
Active ingredient: Iron sucrose
Therapeutic indication: Treatment of anaemia caused by iron deficiency. -
Product Abiraterone acetate
Scinopharm Taiwan Ltd offers a wide range of products with US DMF or EDMF which includes Abirterone Acetate. Contact us for more information. -
Product PRODUCT LIST
ACTH, Abaloparatide, Alarelin, Angiotensin I/II (1-7), Angiotensin II, Arginine Vasopressin, Atosiban, Buserelin, Carbetocin, Carperitide, Desmopressin, Elcatonin, Eledoisin, Etelcalcetide, Fertirelin, GHRP-6, GLP-1 (7-37), Gonadorelin, Goserelin, Icatibant, Lanreotide, Lecirelin, Leuprolide, Lysine Vasopress... -
Product Diazepam
FIS produces a wide range of API's which includes Diazepam. It is commercially available. Contact us for more information. -
Product Benidipine HCl
Recordati S.p.A provides a wide range of active pharmaceutical ingridients which includes benidipine HCl. It belongs to antihypertensive category. Contact us for more information. -
Product COATSOME® FE-4040MA3 (DMPE-MAL)
Nof Europe offers a wide range of drug delivery products which includes coatsome® fe-4040ma3 (dmpe-mal). Contact us for more information. -
Product PROSTAGLANDINS
Newchem Spa provides wide range of active pharmaceutical ingredients which includes Prostaglandins. Contact us for more information. -
Product Meropenem Trihydrate (sterile) (API)
Savior Lifetec Corporation manufactures sterile carbapenem antibiotic which includes meropenem (sterile bulk). It is a broad spectrum, beta-lactamase resistant, carbapenem antibiotic for parenteral administration. It readily penetrates through the cell wall of most gram-positive and gram-negative bacteria to ... -
Product Bisoprolol hemifumarate
SCI Pharmtech, Inc. offers a wide range of active pharmaceutical ingredients which includes bisoprolol hemifumarate. Contact us for more information. -
Product Apixaban
Neuland Laboratories Limited offers a wide range of API's which includes Apixaban. Therapeutic segment: Anticoagulant . Contact us for more information. -
Product 18β-GA
Indena SpA offers a wide range of pharmaceutical products which includes 18β-GA. Botanical origin: Glycyrrhiza glabra L. Biological activity: Anti-inflammatory. Contact us for more information. -
Product Acarbose
Hangzhou Zhongmei Huadong Pharmaceutical provides wide range of pharmaceutical products which includes acarbose. It belongs to active pharmaceutical ingredient category. Contact us for more information. -
Product Montanide™ Range
SEPPIC SA offers a wide range of products which includes montanide™ range. Features: it can used in about 300 clinical trials from phase i to phase iii. Contact us for more information. -
Product Sufentanil
This API is part of the FCC product portfolio and is available for selected markets only -
Product Latanoprost
Latanoprost is a type of prostaglandin. It is indicated for antiglaucoma treatment. Originator: Pfizer. Brand: Xalatan. Contact us for more information. -
Product Quetiapine fumarate
We are providing following documents or certifications of this product: GMP,USDMF -
Product Lamivudine
Shijiazhuang Lonzeal Pharmaceuticals Co Ltd offers a wide range of products which includes lamivudine. It belongs to antiviral drugs APIi category. APIplication: anti-viral drug substance. Contact us for more information. -
Product Bismuth Subsalicylate
Bismuth Subsalicylate is an antacid API used to treat discomforts of the stomach and gastrointestinal tract, such as diarrhea, indigestion, heartburn and nausea.
Available in different grades for solid and liquid formulations. -
Product Metformin Hydrochloride (BP/IP/USP/Ph. Eur.)
ACPL is a 'global scale' producer of Metformin hydrochloride (Active ingredient) with dedicated CEP/ISO/GMP approved facilities having market leadership and a well established status as 'supplier of choice' with hundreds of customers worldwide. Our customers include some of the leading Pharmaceutical compan... -
Product Diacerin
Shubham Pharmachem Pvt. Ltd. provides wide range of pharmaceutical products which includes Diacerin.It belongs to Active Pharmaceutical Ingredients category.
Contact us for more information. -
Product Amlodipine Besylate API and intermediates
We manufacture API and intermediate - CEP & USDMF filed. contact - [email protected] -
Product ASCORBYL PALMITATE
Ascorbyl palmitate is an ester, formed from ascorbic acid and palmitic acid creating a fat-soluble form of vitamin C.
In addition to its use as a source of vitamin C, it is also used as an&... -
Product Heparins
Biofer SpA offers a wide range of heparins and heparinoids which includes heparin sodium. It belongs to antithrombotic category. It is topical and injectable grade. It is white or almost white hygroscopic powder. Packaging: It is packed in tight light resisitant aluminium containers sealed with rubber closure... -
Product Artesunate
Micro Orgo Chem offers wide range of api which includes artesunate. It belongs to antimalarial category. Contact us for more information. -
Product FBD Finger Bags
We offer Ultrasonically welded Fluidized Bed Dryer Bags to minimize contamination of stitching thread in your final product. Manufactured with the latest state of Art Technology of European machine. These bags withstand higher pressure drops & do not damage. Available in with & without Antistatic as w... -
Product Olmesartan Medoxomil
Nutra specialities private limited provides wide range of pharmaceuticals products which includes olmesartan medoxomil. It is used to treat hypertension (high blood pressure). It works by blocking the effect of a hormone called angiotensin II. It substance prompts the blood vessels to contract, an action tha... -
Product Alfaepoetin -Rhu
BLAU FARMACÊUTICA S/A offers a wide range of products which includes alfaepoetin -rhu. Contact us for more information. -
Product MENTHOL AND MINT OILS
AOS Products Pvt Ltd offers impeccable quality of Menthol Crystals, Mint Oils, Spearmint Oil, Peppermint Oil, Indian Piperita Oil, Basil Oil and derivatives of all these Oils. We offer these products as per Indian Pharmacopeia, British Pharmacopeia, US Pharmacopeia etc. -
Product Methylcobalamine (Mecobalamine)
Largest Manufacturer for Methylcobalamine In India with a capacity of 350 Kg per month.
Grade : IP / JP / USP
Certifications : WHO-GMP / US-FDA (Food) / PMDA (Pre-Audit)
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Product SGM
Sugammadex is one of the greatest successes in the history of cyclodextrins. There is an increasing interest for this product and for the development of Sugammadex since the approval by the FDA resulted in a 3-4-fold increase in the global sales of the product. SGM is used in anesthesia as an injectable antid... -
Product Sodium hyaluronate ph. Eur.
Kraeber & Co GmbH offers a wide range of pharmaceutical products. We are GMP, GDP and ISO 9001:2015 certified. You can find our catalogue and product list in the download files. For further information, please contact us: www.kraeber.de -
Product Dibasic Calcium Phosphate dihydrate IP/BP/USP
Dibasic Calcium Phosphate dihydrate also known as Dicalcium Phosphate Dihydrae,Calcium hydrogen phosphate dihydrate ,DCP Dihydrate and Calcium Hydrogen Phosphate Phosphoric acid is used in Pharmaceutical Industry as fillers & binding agent for tablets & capsules.It is also used as API. -
Product Alclometasone Dipropionate
Teva Active Pharmaceutical Ingredients (TAPI) offers a wide range of products which includes alclometasone dipropionate. Therapeutic category: d-dermatologicals. Contact us for more information. -
Product Calcium Gluconate
High quality API for oral and parenteral dosage form registered with US DMF. -
Product Alugel® A 211
Elementis Pharma GmbH offers a wide range of products which includes Alugel® A 211. It belongs to antacid compounds category. Alugel® A 211 is the most widely used active for tablet, granulate or powder manufacture. Its high reaction capacity with hydrochloric acid ensures rapid onset and prolonged action in ... -
Product Tinidazole
The product has been approved by US FDA and EU EDQM, local GMP , EU GMP, CEP and DMF are available. -
Product Active Pharmaceutical Ingredients (API)
Neopharma supplies NCEs, cGMP intermediates and KSMs to global innovators. It is equipped with flexible, versatile and advanced infrastructure, tailored to fit any complex chemistry molecules. Our API manufacturing facilities comply with all regulatory guidelines and requirements of current Good Manufacturing... -
Product Pyrimidines, Purines, Carbohydrates, Nucleosides, Nucleotides, Chiral compounds
Your partner for API's production supplying chain
Product Development & Process InnovationOrganic Synthesis & Enzymatic Synthesis
Product Quality & Cost Efficiency
cGMP Regulatory Compliance &TDP Support
Professional Commercial Service -
Product Adenosine (Adenosine)
Yamasa corporation offers a wide range of biochemicals products which includes adenosine (adenosine). Contact us for more information. -
Product Aptimust Syrup
Mankind Pharma Limited offers a wide range of products which includes aptimust syrup. Active ingredient: cyproheptadine hydrochloride 2mg+tricholine citrate 275mg + sorbitol solution (70%) 2gm)/5ml. Package detail: 200 ml. Form: syrup. Contact us for more information. -
Product Calcium Chloride-2-Hydrate
CFL-Chemische Fabrik Lehrte GmbH provides wide range of products which includes calcium chloride-2-hydrate. Contact us for more information. -
Product Bortezomib
Qilu Pharmaceutical Co., Ltd offers wide range of API which includes bortezomib. Therapeutic category: oncology. Contact us for more information. -
Product Artemether (Ph.Int. / IP)
A white crystalline powder. Practically insoluble in water, very soluble in Dichloromethane & in Acetone, freely soluble in Ethyl acetate & in dehydrated Ethanol. Melting range - 86°C to 90°C -
Product Alprazolam
Centaur Pharmaceuticals Private Ltd provides wide range of products which includes alprazolam. Contact us for more information. -
Product Blending Solution
Avara Pharmaceutical Services offers clinical-scale drug product manufacturing services, including blending. Contact us for more information. -
Product Bicalutamide
Bicalutamide is available with quality of Ph.Eur and with EU DMF. Packaging: 10 kg. Contact us for more information. -
Product Fenbendazole
Veterinary API. Therapeutic Category: Anthelmintic. USVMF: Filed, EDMF & CEP: Available. Contact us for more information. -
Product cocaine hydrochloride
Mallinckrodt Chemical Ltd offers a wide range of products which includes cocaine. Contact us for more information. -
Product Aceclofenac BP / EP (CEP)
Amoli Organics Pvt. Ltd. is an API (Active Pharmaceutical Ingredients) manufacturer situated in Mumbai, India. We have two world class, WHO-GMP plants that are audited and approved by EU GMP & USFDA. -
Product Chlorhexidine Gluconate
Chlorhexidine Gluconate/Di gluconate Solution, manufacture as per BP/USP/EP/JP/IP DMF, CEP, REACH, WC Available -
Product Cartigen®
Getz Pharma (Pvt) Limited offers a wide range of products which includes cartigen®. Features: it is used to relieve pain and improve function in patients with mild to moderate osteoarthritis. Contact us for more information. -
Product Metoject/Metex Pre-Filled Syringe (Methotrexate)
medac offers a wide range of products which includes metoject®/metex® 50 mg/ml pre-filled syringe (methotrexate). Contact us for more information.
What are Active Pharmaceutical Ingredients (API)?
Drugs are composed of two major components: – Active pharmaceutical ingredient (API), and excipients. APIs vary from drug to drug and are responsible for creating the intended biological, physiological or therapeutic effect within the recipient's (patient's) body. A drug can contain one or more APIs depending on its purpose and the synergistic actions of the APIs.
Active pharmaceutical ingredients (APIs) are the therapeutically active substances or chemical components of drug products (capsules, tablets, syrups, etc.) that produce an intended pharmacological effect.
The APIs within drugs are conveyed into the body through inactive components known as excipients, which usually make up the bulk of the drug. They facilitate the ingestion, absorption, and distribution of the active ingredients. These excipients serve as vehicles and are usually inert or biologically inactive.
Source APIs from our marketplace of 900+ global API manufacturers and 2,500+ API solutions in categories such as Amino Acids, Enzymes, Antibiotics, Antibodies, Sera and Vaccines and more.
What is the purpose of APIs?
APIs are the primary ingredients contained in drugs and medicines. They play a significant role in drug production and produce pharmacological effects within the body. The pharmacological effects produced, directly or indirectly, influence the diagnosis, symptom relief, mitigation, treatment, cure, or prevention of diseases. APIs also modify, correct, or enhance the physiological function and structure of chemicals, cells, tissues, and organs within the body. In simple terms, they make the drug or medicine work.
What is the overall size of the API market?
With the exponential rise in the global population, the growing demand for a therapeutic solution to critical and chronic diseases, change of lifestyle, and the increasing importance of generics globally, the need for active pharmaceutical ingredients has skyrocketed. As a result of these, the API market growth is increasing at a rapid rate.
Based on research, the global active pharmaceutical ingredient market had an estimated value of $168.87 billion in 2019 and is presently worth $ 187.3 billion. However, the global market is expected to grow by the US $ 100 – 120 billion dollars in the next seven years to attain a market value of US $285.5 billion by 2027. The growth of the API market is expected to move at a CAGR of 6.8% during the forecast period.
This research covers growth trends and competitions in significant regions where APIs are actively manufactured and distributed. These regions include Europe, North America, Latin America, Middle and East America (MEA), and Asian Pacific (APAC). Although the majority of API manufacturing companies are located in the United States, others are located in India and China.
How APIs are synthesized?
API synthesis is a complex multi-step process that involves a wide range of chemical processes and reactions of varieties of raw materials by physical and chemical means. Specialized professionals in API manufacturing companies perform the process of active pharmaceutical ingredient synthesis and manufacturing.
APIs can be synthesized through 3 major processes – Biological process, organic chemical synthesis, and extraction from a biological source. The method used depends on the raw material involved, steps of the process, and complexity of the API molecule.
What steps are involved in the synthesis of APIs?
APIs are tiny complex molecules produced through a variety of processes. The complexity of the active pharmaceutical ingredient to be synthesized plays a significant role in determining the process used and the steps involved in the process. The steps involved in each of the three processes vary. Synthesis of APIs through biological processes include inoculum and seed preparation, fermentation, and product recovery.
Organic chemical synthesis of APIs involves the use of organic and inorganic chemicals and reactors to produce APIs. This process usually consists of the production of intermediates during chemical reactions. In some cases, these intermediates can be used to produce different APIs or used as a separate pharmaceutical entity. Extraction of APIs from a biological source involves passing natural materials through batch processes to extract or produce a pharmacologically active substance.
Although the stages involved in the various processes differ, they are all grouped into different stages - the introduction of raw materials, production of intermediates, isolation, and purification, and physical processing and packaging.
Given that technology is continually evolving, continuous flow-system has been introduced to enhance the API synthesis and manufacturing process.
How long does it take to synthesize APIs?
The length of the manufacturing process is majorly dependent on the complexity of the API molecule to be synthesized and the process used. API synthesis is a long and complicated process that may take months and sometimes, up to years to complete. The complexity of the structure influences the API synthesis period length, the number of steps in the synthesis route, type of synthesis, cost of the process, drug impurities present, number of APIs to be produced, and the number of isolation steps involved.
What is the goal behind the synthesis of APIs?
API synthesis facilitates the processing and manufacturing of pure pharmaceutical preparations (APIs) for clinical use. Through API synthesis, these active ingredients are extracted, purified, and packaged for treatment, diagnosis, cure, mitigation, and prevention of diseases. These APIs are synthesized and manufactured into biologically secure forms and substances to produce specific pharmacological effects within the recipient's body. Simply put, the primary goal of API synthesis is to create pure, potent, and safe APIs for drug development and production and administration to patients.
Challenges with API reactions and drug interactions
APIs make up the primary ingredients within drugs and are mostly responsible for drug-drug interactions. These drug-drug reactions constitute one of the major causes of failed treatment in patients as well as the production of adverse drug effects in them. Also, reactions of APIs combined within the same drug pose a significant challenge to API manufacturers and the healthcare industry.
How do API and drug interactions occur?
API and drug interactions usually occur as a result of poly-therapy, and this is mostly seen amongst elderly patients. With poly-therapy, the API of one drug interferes with the pharmacological activity of another, by enhancing or inhibiting the function of the other. These reactions usually result in diverse severe health implications and some scenarios, death. This interaction is significantly influenced by the pharmacodynamics of the body and the pharmacokinetics of the drug.
API and drug interaction can either occur during absorption, distribution, metabolism, or excretion of the drugs. Co-administration of drugs (polytherapy) greatly influences the body's response to them, and the risk of API and drug interaction rises as the number of medications administered increases. These reactions are why the API of drugs is taken into consideration when administering several drugs at once or concomitantly.
How does drug data sharing work?
The increasing need for transparency between research participants, publishers, research funders, pharmaceutical companies, regulating bodies, and trading companies during clinical trials has heightened the demand for drug data sharing. Though not yet fully established in some countries, several data sharing policies and guidelines have been set up to support this movement.
Through drug data sharing, clinical results, data, and clinical trial practices are shared and made available to pharmaceutical companies, research investigators, institutions, and other sectors to improve public health, drug development, and boost patient safety. Clinical data is shared at participant and company-level to improve company practices and public trust.
How do you set up the testing parameters of API reactions?
API testing ensures the production of stable and quality active pharmaceutical ingredients. The strength, quality, and stability of APIs are assessed by the manufacturers and regulating agencies through specific standards. Although this is done for all APIs, the testing parameters set up will vary based on the API and the brand. The primary test carried out is the stability test, and it includes stress-testing, storage conditions testing frequency, container closure system, specification, and selection of batches.
The quality of an API is directly proportional to the potency, efficacy, and safety of the medication. Low quality and compromised APIs harm the recipient's health. To ensure the production of high-quality and stable APIs, pharmaceutical companies are only allowed to handle one or two stages of the drug production process. Also, outsourced APIs and locally produced APIs and medications are thoroughly screened and tested to ensure the quality and safety of drugs.
What role does an API manufacturer play in pharmaceutical research?
The API manufacturers constitute a significant part of the pharmaceutical company globally, as well as the healthcare industry. They help to improve and facilitate pharmaceutical research in many ways. API manufacturers play a significant role in pharmaceutical research by conducting research and providing fact-based data and results on APIs and their pharmacological effects on the body.
Through in-depth analysis and a combination of efforts and contributions from active pharmaceutical ingredients manufacturers and other professionals in the pharmaceutical industry, potent and safer drugs can be developed to improve healthcare delivery.
What are the key market trends in API manufacturing?
The global demand for active pharmaceutical ingredients is on the rise, and there are a variety of factors that have actively contributed to its growth. Some of the key trends driving the development of the global active pharmaceutical ingredient market and API manufacturing include the worldwide rise of chronic diseases as well as the increasing demand for and importance of generics. Over the years, there's been a growing prevalence of chronic diseases such as chronic obstructive pulmonary disease (COPD), arthritis, hepatitis, cancer, etc., in various parts of the world.
The rapid rise of these diseases can be attributed to the increase in the geriatric population across the world. With this population experiencing a lifestyle change, and dietary consumption as a result of urbanization, an increase in the occurrence of chronic diseases such as cancer, is expected. This, in turn, will affect demand, as well as positively influence the market.
Also, as a result of technological advancement in active pharmaceutical ingredient manufacturing, the global API market is taking a huge turn around. Besides, another key trend that has positively influenced the market is the increased use of artificial intelligence-based drug discovery and production.
Market trends that have negatively influenced the global API manufacturing market include the cost of drug monitoring in other countries, intense competition between API manufacturers, and increasing production of anti-counterfeit drugs. The major market trend that has negatively influenced the market is the high cost of manufacturing APIs and unfavourable drug pricing control policies in countries across the world.
What are the key players in the active pharmaceutical ingredients market?
There are several competitor pharmaceutical companies working in the global active pharmaceutical ingredients market. These API manufacturing companies have contributed a great deal to the growth of the global API market. Some of the prominent and leading API companies include:
- Pfizer Inc. (US),
- TAPI (Teva Active Pharmaceutical Ingredients Israel),
- Sun Pharmaceutical Industries Ltd. (India),
- Aurobindo (India),
- Novartis International AG (Switzerland),
- Boehringer Ingelheim (Germany),
- Abbott (US),
- AbbVie (US),
- GlaxoSmithKline Plc (UK),
- Merck &Co. Inc. (US) amongst many others.
Regardless of these strategies, these key players in the global API market are still likely to face tough competition from new and upcoming companies in the industry.
References
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