Bachem AG

Fields of Application: Conjunctivitis.  Antazoline Hydrochloride is an ethylenediamine derivative with antihistaminic properties and is used in conjunction with a vasoconstrictor for ocular allergies.

Fields of Application: Conjunctivitis. Antazoline Hydrochloride is an ethylenediamine derivative with antihistaminic properties and is used in conjunction with a vasoconstrictor for ocular allergies.

Fields of Application: Conjunctivitis. Antazoline Sulsphate is an ethylenediamine derivative with antihistaminic properties and is used in conjunction with a vasoconstrictor for ocular allergies.

Fields of Application: Parkinson's disease. Carbidopa, an aromatic L-amino acid decarboxylase inhibitor, which does not cross the blood-brain barrier, is routinely administered in combination with levodopa to patients with Parkinson’s disease to reduce the peripheral decarboxylation of levodopa to dopamine.

Fields of Application: Anesthesia. Etomidate is a rapid, short acting intravenous anesthetic agent with no analgesic properties and a relative lack of significant hemodynamic and respiratory effects.

Fields of Application: Sedation, Anesthesia. Propofol is an intravenous, short acting anesthetic with rapid onset of action.

Fields of Application: Premature labor. Atosiban is an oxytocin and vasopressin antagonist. It is used as a tocolytic in the management of preterm labor.

Fields of Application: Moderate to high risk acute coronary syndromes. Percutaneous coronary intervention. Bivalirudin is a hirudin analog. It acts as a specific and reversible direct thrombin inhibitor.

Fields of Application: Use in reproduction medicine. Advanced hormone-dependent prostate cancer Endometriosis, Central precocious puberty, Uterine myoma. Buserelin is a potent LHRH agonist. After a transient increase, continuous administration results in downregulation of LH and FSH levels followed by a su...

Fields of Application: Nocturnal enuresis, Central diabetes insipidus, polyuria, polydipsia, Mild and moderate forms of hemophilia A and von Willebrand disease. Desmopressin is a synthetic analog of vasopressin with low vasopressor activity. Apart from its increasing effect on water resorption by the kidne...

Fields of Application: Hypoglycemia (due to diabetes mellitus). Glucagon opposes the action of insulin. It enhances the synthesis and mobilization of glucose in the liver.

Fields of Application: Ovarian follicular cysts (veterinary medicine), Use in reproduction medicine, Diagnosis of the hypothalamic-pituitary-gonadal axis function, Cryptorchism, Synchronization of ovulation (veterinary medicine). Gonadorelin is also known as LHRH or GnRH.After a transient increase, continu...

In our studies in collaboration with Novo Nordisk, we set out to identify environmentally benign solvents suitable for large-scale SPPS of peptide therapeutics at ambient temperature by assessing reagent solubility, resin swelling, amino acid coupling and Fmoc-removal efficiency in a collection of REACH compatible neat solvents and selected binary solvent mixtures. These studies have shown that binary solvent mixtures are indeed viable alternatives.

The Molecular Hiving™️ technology is especially suitable for the synthesis of peptide ingredients for cosmetic products, as CMR solvents and reagents can entirely be avoided during the manufacturing process.

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As the world’s leading company in the development and production of peptides and oligonucleotides (TIDES), Bachem is a strategic partner for Biotechnology, Pharmaceuticals, Diagnostics, Cosmetics and Life Science research. We work in close collaboration with our customers to ensure the success of their ambitious product development programs.Innovation is one of our key success factors. We are not only producing peptides and oligonucleotides in large quantities in modern industrial production facilities; we are also automating our manufacturing processes wherever possible. We have set new standards in quality, increased efficiency and reduced solvent volumes. There is an increase in the therapeutic use of oligonucleotide-based drugs. The category is also expanding from rare diseases into chronic diseases, with the potential to make a huge difference to more lives. We identified this need for oligonucleotide therapeutics to address larger-scale patient populations and indications. This is driving our commitment and journey in oligonucleotide NCEs: we want to help build a new future.

The Bachem Group (SIX: BANB) today announced measures and decisions designed to ensure that the global market is kept supplied with the active pharmaceutical ingredient Propofol from its Swiss production site in Vionnaz.

Bachem covers the entire life cycle of an active pharmaceutical ingredient (API), from early discovery to research grade catalogue item, to Good Manufacturing Practice (GMP) grade API suitable for clinical trials and drug products and, ultimately, to a high-quality and state-of-the-art generic API.

We can fulfill your needs from a few grams to multi-kilogram to tenth of tons of generic API using different organic, Solid Phase Peptide Synthesis (SPPS), Liquid Phase Peptide Synthesis (LPPS) or mixed peptide chemistries, from our four GMP manufacturing plants located in Europe and in the US.

With over 50 years of experience, Bachem is your innovative partner for the most sophisticated peptides and organic compounds and is ready to fully support you from development, to registration and reliable commercial supply for your next project.

Microparticle formulation has been successfully applied in a number of commercial products containing peptides as APIs. The use of nanoparticles for delivering proteins and peptides are still in early stages of development. Discover how Bachem is part of this technology!

Like all drug substance material, synthetic peptides manufactured under GMP conditions require stringent analytical tests for release and use in humans for clinical trials and approved treatments.

Long or strongly hydrophobic peptides may aggregate and become challenging to handle, either for further chemical reactions or for purification. PEC platform represents an opportunity to overcome these drawbacks and may facilitate and/or accelerate the purification process.

An in-depth look at the Japanese Pharma market. Hear from Associations and Analysts on market potential, challenges and opportunities, and from pharma companies who have successfully built a business in the market. Aired as part of the CPHI Festival of pharma

Improving the sustainability in the CDMO industry is a multi-facetted approach covering environmental, economic and social tasks while having a strong focus on these areas where a company can make the highest impact. Bachem, the leading manufacturer of peptides and oligonucleotides is a good example for using this approach successfully. By innovating for better manufacturing the company could massively reduce greenhouse gas emissions and solvent consumptions: something that is also of utmost interest when searching for a partner for large-scale production of oligonucleotides and peptides.