Boosting capabilities through collaboration
CDMO, Micro-Sphere partners with German machine manufacturer Harro Höfliger for the latest step in its 21 million CHF (€19 million) investment into its facility in Switzerland.
Micro-Sphere, a CDMO specialising in the spray drying of APIs and HPAPIs, noticed a growing interest in using spray drying as a technology for particle engineering in the field of respiratory dry powders. Listening to respected and long-standing clients and keeping abreast of technological advances in the market, the CDMO decided to increase its capabilities, adding new technology to satisfy clients' new needs.
After consulting a number of experts and suppliers, and considering various options, Micro-Sphere concluded their next logical step was to source a technical partner to supply the best available technology to fill spray-dried powder in capsules ‒ the Harro Hofliger Modu-C MS unit.
This capsule filling machine boosts Micro-Sphere’s capsule filling production. A notional production of 72,000 capsules per hour and a 100% net weight check control, grant the correct dose when filling capsules for dry powder inhalers.
Micro-Sphere was satisfied that Harro Höfliger offered the best technology to handle cohesive spray-dried powders for respiratory applications and would be the right partner for the job.
Spray dried powders are sensitive and versatile in terms of physical characteristics and handling needs. The Modu-C Drum dosing technology has the capability to allow for careful powder feeding and precise metering without causing negative impact on final product performance (powder dispersion, stability, etc.) and is therefore the perfect solution for Micro-Sphere's needs.
Adding this capacity has given Micro-Sphere a powerful tool to cover client needs from clinical through to commercial launch.
Micro-Sphere founder and president of the Board, Dr Michele Müller, said: “Low-dose capsule filling is becoming increasingly popular across the market and at present we are the only CDMO in Europe offering this level of capability.
“Harro Höfliger’s powder expertise and technological competence is particularly evident in the Modu-C MS. This investment is an important next step in our expansion plans, allowing us to meet demand for greater capacity and speed up project delivery for our customers.”
Based in Allmersbach, Germany, Harro Höfliger develops and manufactures production and packaging systems and is a valued development partner for many pharmaceutical and medical technology companies.
Marco Laackmann, business unit leader, inhalation at Harro Höfliger added: “The capacitive fill quantity control of the Modu-C MS offers excellent process reliability and is a great choice for Micro-Sphere in line with its continued expansion. We’re delighted to be a part of their exciting future.”
Having been through the process of increasing capsule-filling capabilities, what has Micro-Sphere learnt and what advice can they offer companies in a similar situation?
First, the CDMO would encourage companies to consider collaborative working. "Besides the purchase of a piece of equipment, both companies are technology-driven and service orientated and this has created a positive, winning relationship for both the companies involved and our clients that can have their dry powder inhalers capsules quickly and properly filled under GMP."
It doesn't end with the delivery of the machinery either. Harro Höfliger offers continuous and competent postsale support, and as a result Micro-Sphere is learning how to get the best from the Modu-C-MS unit. Thanks to its clients and Micro-Sphere's spray drying expertise, Harro Höfliger is also learning more about challenges posed by cohesive spray-dried powders.
Micro-Sphere and Harro Höfliger teams are already working together side by side at Micro-Sphere's site to deliver more success stories.
Related News
-
News Patients vs Pharma – who will the Inflation Reduction Act affect the most?
The Inflation Reduction Act brought in by the Biden administration in 2022 aims to give better and more equitable access to healthcare in the USA. However, pharma companies are now concerned about the other potential costs of such legislation. -
News CPHI Podcast Series: What does the changing US Pharma market mean for industry and patients alike?
In this week's episode of the CPHI Podcast Series Lucy Chard, Digital Editor for CPHI Online is joined by James Manser to discuss the political and market changes in the US pharma field. -
News CPHI Barcelona Annual Report illuminates industry trends for 2024
The CPHI Annual Survey comes into it’s 7th year to report on the predicted trends for 2024. Over 250 pharma executives were asked 35 questions, with their answers informing the industry landscape for the next year, spanning all major pharma marke... -
News Which 10 drugs are open to price negotiation with Medicare in the USA?
The Centres for Medicare & Medicaid Services, under the Biden administration in the USA, has released a list of the 10 drugs that will be open to price negotiations as part of the new legislation under the Inflation Reduction Act (IRA). -
News EU Medical Devices Regulation causes unintended disappearances of medical devices for children, doctors state
Doctor groups and associations have appealed to the EU to correct the EU Medical Devices Regulation law that may cause unintended shortages of essential drug and medical devices for children and rare disease patients. -
News 10 Major Drug Approvals So Far in 2023
Last year, 37 novel drugs were approved by the FDA, this was a high number for such a category, and covered many fields including oncology, demonstrating how promising further research is, and how it is only continuing to build. To date, there are alre... -
News Detecting Alzheimer's disease with a simple lateral flow test
A novel rapid diagnostic test for early-stage Alzheimer's disease has been developed using a biomarker binder from Aptamer Group along with technology from Neuro-Bio, the neurodegenerative disease experts. -
News CPHI Podcast Series: outsourcing and manufacturing trends
Listen to the CPHI Podcast Series this June to hear Gil Roth of the PBOA speak with Digital Editor Lucy Chard about the biggest trends and topics to watch in pharma outsourcing and manufacturing at the minute.
Position your company at the heart of the global Pharma industry with a CPHI Online membership
-
Your products and solutions visible to thousands of visitors within the largest Pharma marketplace
-
Generate high-quality, engaged leads for your business, all year round
-
Promote your business as the industry’s thought-leader by hosting your reports, brochures and videos within your profile
-
Your company’s profile boosted at all participating CPHI events
-
An easy-to-use platform with a detailed dashboard showing your leads and performance