DRcaps® capsule

DRcaps® capsule
Product Description

DRcaps® capsules are innovative HPMC capsules that can help protect dietary supplement ingredients from stomach acidity without the cost and complexity of adding acid-resistant properties during manufacturing. DRcaps® capsules can also help mask taste and odor and reduce bad aftertaste without the addition of costly coatings.

DRcaps® capsules can be customized with titanium dioxide free colors to obtain a transparent, semi-opaque or fully opaque effect.

Lonza Capsules & Health Ingredients

  • BE
  • 2015
    On CPHI since
  • 5000+
Company types

Lonza Capsules & Health Ingredients

  • BE
  • 2015
    On CPHI since
  • 5000+
Company types

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Lonza Capsules & Health Ingredients resources (24)

  • News On track at CPHI Barcelona - The Track Sponsor interview: Lonza

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  • News The Top 5 Industry Content Reads on CPHI Online

    If you’re looking for news, product information and market trends from leading pharma companies, the CPHI-Online.com Company Showcases are a great resource for buyers who want to stay up to date, browse product portfolios and find the right partner. 

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    Rapid and efficient development of drug candidates is increasingly important for pharmaceutical companies with accelerated timelines and funding constraints. However, many early drug candidates have poor oral absorption properties making it challenging to achieve target pharmacokinetic (PK) profiles. Without upfront knowledge of absorption risks and mitigation strategies, poor absorption can significantly impact preclinical and clinical study timelines and costs. Physiologically-based pharmacokinetic (PBPK) modeling software, such as the GastroPlus® platform from Simulations Plus, simulates dynamic physiological factors impacting oral performance. When coupled with in vitro measurements, PBPK modeling is effective in early development for 1) identifying absorption risks, 2) assessing the potential for solubility enhancing formulations such as salts, cocrystals, or amorphous solid dispersions to mitigate these risks, and 3) designing and optimizing preclinical and clinical studies with respect to dose, prandial state, or gastric pH modification to maximize the likelihood of achieving desired PK profiles. In this presentation, we will demonstrate how PBPK models combined with Lonza’s custom and off-the shelf in vitro tools and solubility enhancement expertise can be used to identify and mitigate absorption risks in early drug development, reducing the need for drug product reformulation or repeated preclinical or clinical studies. Key Learning Objectives: Learn how PBPK modeling can identify potential oral absorption risks and mitigation strategies (e.g. bioavailability enhancement) for early drug candidates. Learn how PBPK modeling coupled with in vitro testing can guide early selection of drug form and formulation to achieve clinical study goals. Gain insights into how key drug and formulation factors including solubility, permeability, and dissolution rate can impact absorption risks such as poor oral bioavailability, food-drug interactions, and pH-dependent DDI effects.
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