Enhancing the stability and bioavailability of alpha-lipoic acid: Development and evaluation of a liposomal formulation

Objective: To evaluate the physicochemical properties, stability, and absorption behavior of a liposomal Vitamin C formulation developed by West Bengal Chemical Industries Ltd. (WBCIL) using non-genetically modified sunflower-derived phosphatidylcholine, with a focus on its potential as a topical alternative to conventional Vitamin C supplements

Methods: The liposomal formulation was synthesized and subjected to comprehensive characterization using advanced analytical techniques. High-Performance Liquid Chromatography (HPLC) was used to determine encapsulation efficiency. Fourier Transform Infrared Spectroscopy (FTIR) was employed to identify functional groups, while X-Ray Photoelectron Spectroscopy (XPS) confirmed elemental composition. Dynamic Light Scattering (DLS) was used to measure hydrodynamic particle size, zeta potential, and polydispersity index. Stability and sustained release of Vitamin C were evaluated under physiological and thermal conditions.