From Conventional Batch Lyophilizer to Continuous Spin-Freeze-Drying Technology: Lyophilized Drug Product in hours instead of days
Freeze-dried product
Continuous spin freeze-drying integrates spin-freezing, primary drying, and secondary drying into a fully continuous process. During spin-freezing, vials are rotated under a controlled gas flow, creating a thin and homogeneous frozen layer along the vial wall. This configuration enhances heat and mass transfer, accelerates sublimation, and has the potential to substantially reduce freeze-drying cycle times while maintaining product quality.
In this context, the R&D Formulation and Analytical Development Laboratory of Thermo Fisher Scientific (Monza, Italy) investigated the application of the RheaVita continuous lyophilization technology to a challenging formulation, in comparison with a conventional lyophilizer.
Cake appearance of RheaLyo vial.
