Precise and Accurate CHN Data from Low Weight Samples

A new report from Exeter Analytical demonstrates how the Model 440 CHN Analyser provides precise and accurate determination of percentage carbon, hydrogen and nitrogen on samples as small as 0.3 mg.

Using Atropine (8-Methyl-8-azabicyclo[3.2.1]oct-3-yl) 3-hydroxy-2-phenylpropanoate) as the test compound the Model 440 produced data from 0.3 mg samples which only varied within +/- 0.12% of the theoretical CHN values. In environments such as pharmaceutical research and synthetic chemistry laboratories, where the weight of new compounds for analytical purposes is often limited, the ability to reliably generate reliable CHN data on sub 0.5 milligram samples is highly valuable.

The Exeter Analytical Model 440 is a static combustion CHN Elemental Analyser, with a unique horizontal furnace design, which enables easy removal of sample residue between each analysis.  Because the Model 440 is able to effectively eliminate troublesome residue build-up, its gas flow characteristics are superior to other CHN Analysers leading to longer-term calibration stability, as well as enhanced accuracy and precision for measured sample data.

Because the Model 440 provides complete control over combustion parameters it is able to reproducibly achieve 100% combustion with the widest range of sample types. Through incorporation of extensive automation in the Model 440 and intuitive software – the percentage Carbon (C), Hydrogen (H) and Nitrogen (N) in samples can be determined in as little as 5 minutes.