Quest Journals: Specialized Manufacturing of Calcium Lactate Gluconate (CLG)

Calcium, the most prevalent mineral in the human body, is crucial for maintaining bone and dental health. Adequate calcium intake is essential, with the Indian Council of Medical Research recommending 600-800 mg/day for adults and 1200 mg/day for pregnant and lactating women. Insufficient intake can lead to osteopenia and osteoporosis, making supplementation important. Among various forms, calcium lactate gluconate (CLG) stands out for its high solubility and bioavailability. This paper explores the synthesis, properties, and benefits of CLG, particularly a novel formulation by West Bengal Chemical Industries (WBCIL) where lactate and gluconate molecules are bonded to a single calcium ion, enhancing stability and absorption. WBCIL employs advanced analytical techniques such as FT-IR and NMR spectroscopy, alongside rigorous testing for heavy metals and microbial contaminants, ensuring the highest standards of safety and efficacy. The paper discusses the superior solubility, tr...

Calcium is the most prevalent mineral in the human body, with about 99% stored in bones and teeth.1 It can be found in both plant-based and animal-based foods, with milk being a particularly rich source. The Indian Council of Medical Research (ICMR) recommends a daily calcium intake of 600-800 mg for adults. This requirement increases to 1200 mg per day for pregnant and lactating women. 2 Chronic insufficient calcium intake can result in conditions such as osteopenia and osteoporosis.3 To address these deficiencies, calcium supplementation is essential. There are several forms of calcium supplements available, including organic salts such as tricalcium citrate, calcium lactate, calcium lactate gluconate, and calcium gluconate, as well as inorganic salts like calcium chloride, calcium carbonate, and calcium phosphate. 4 The selection of a calcium salt is influenced by factors such as calcium content, solubility, taste, and bioavailability, with higher solubility generally leading to better calcium absorption. Notably, calcium lactate gluconate (CLG), formed from the combination of calcium lactate and calcium gluconate, stands out as a highly soluble calcium form. 4 Some supplements are available in the name of calcium lactate gluconate as a mixture of calcium lactate and calcium gluconate which is chemically different from calcium lactate gluconate. Calcium lactate gluconate is a bidental complex where one ligand is lactate ion and another ligand is gluconate ion and both these ions are attached to the single calcium ion. With its chemical formula C9H16CaO10, calcium lactate gluconate (CLG) demonstrates high bioavailability and water solubility, making it an excellent option for supplementation. CLG is essential for providing elemental calcium, which is vital for numerous physiological processes such as bone health, muscle function, and nerve communication