RP5063 shows positive signs for the treatment of schizophrenia
A new drug has been shown to be potentially effective for the treatment of schizophrenia.
A Phase 2 clinical trial has shown the dopamine serotonin stabiliser RP5063 may be effective for the treatment of schizophrenia and schizoaffective disorder.
That is according to Reviva Pharmaceuticals, which explained the trial was carried out across 234 patients in the US, Asia and Europe.
Participants with schizophrenia or schizoaffective disorder were randomised and treated for a month with either RP5063 at doses of 15mg, 30mg or 50mg per day, or a placebo or control arm of aripiprazole at 15mg.
"The favourable tolerability data also lends support to trials in even more fragile populations such as geriatrics and pediatrics," said study investigator Mark Novitsky.
According to the results of the research, there were no clinically significant differences in systematic side effects between RP5063 and the placebo drug, including motor function.
There was also no apparent side effects in prolactin related sexual problems which the study observed are a common side effect of current antipsychotic treatments.
Related News
-
News Understanding the Benefits and Advances of Cleanroom Technology
In an industry where precision and sterility are crucial concerns, cleanrooms play a vital role in maintaining the integrity of pharmaceutical products like drugs, vaccines, and other medical products. So, what is a cleanroom?
-
News AbbVie secures GBP£1.2 billion deal for Gilgamesh’s psychedelic programme
AbbVie has penned a significant agreement to acquire the bretisilocin programme from Gilgamesh Pharmaceuticals for up to £1.2 billion, marking a bold step in the pharmaceutical giant's quest to develop treatments for psychiatric disorders. -
News Gates Foundation commits US$2.5 billion to women’s health research
The Bill & Melinda Gates Foundation has announced a substantial US$2.5 billion commitment to accelerate research and development focused exclusively on women's health through 2030.
-
News Mid-year review: notable FDA drug approvals of 2025
As we fly past the halfway point of 2025, the pharmaceutical landscape reliably continues to evolve with innovative therapies addressing critical medical needs. The FDA has already approved 17 groundbreaking medications this year, each representin... -
News US FDA announces new priority vouchers for accelerated review times
The US FDA announced a new priority program for drug developers – the Commissioner’s National Priority Voucher (CNPV) program aims to enhance the health interests of the US by allowing drug developers to redeem a voucher, shortening th... -
News Google-backed start-up raises US$600 million to support AI drug discovery and design
London-based Isomorphic Labs, an AI-driven drug design and development start-up backed by Google’s AI research lab DeepMind, has raised US$600 million in its first external funding round by Thrive Capital. The funding will provide further power t... -
News AstraZeneca to invest US$2.5 billion in Beijing R&D centre
Amid investigations of former AstraZeneca China head Leon Wang in 2024, AstraZeneca have outlined plans to establish its sixth global strategic R&D centre in China. Their aim is to further advance life sciences in China with major research and manufact... -
News Experimental drug for managing aortic valve stenosis shows promise
The new small molecule drug ataciguat is garnering attention for its potential to manage aortic valve stenosis, which may prevent the need for surgery and significantly improve patient experience.