CGMP IWR-1-endo Ancillary Material

CGMP IWR-1-endo Ancillary Material
Product Description

IWR-1-endo is an inhibitor of the Wnt signaling pathway that acts via inhibition of tankyrases and stabilization of axin. It has been used to maintain proliferation of hematopoietic stem cells, promote pluripotency of human embryonic stem cells, and induce differentiation of progenitor cells. GMP IWR-1-endo Ancillary Material is intended for use in cell, gene, and tissue engineering applications.This product has been manufactured and tested in accordance with GMP principles set forth by the ICH and FDA and meets the expectations for commercial cell, gene, and tissue-engineered products in accordance with USP <1043> “Ancillary Materials for Cell, Gene, and Tissue-engineered Products”.

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Cayman Pharma s.r.o

  • Country/Region:
    Czech Republic
  • On CPHI since:
    2015
  • Certificates:
    3
  • Employees:
    100 - 249
Company types
Manufacturer/Innovator
Primary activities
Generic APIs producer
View company profile
Categories
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Specifications
  • CAS Registry Number
    1127442-82-3
  • Details
    This product has been manufactured and tested in accordance with GMP principles set forth by the ICH and FDA and meets the expectations for commercial cell, gene, and tissue-engineered products in accordance with USP <1043> “Ancillary Materials for Cell, Gene, and Tissue-engineered Products”.
  • Model
    44886
  • Supplied from
    United States
  • Measured In
    gram
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Sales Markets
Show more Show less

Cayman Pharma s.r.o

  • Country/Region:
    Czech Republic
  • On CPHI since:
    2015
  • Certificates:
    3
  • Employees:
    100 - 249
Company types
Manufacturer/Innovator
Primary activities
Generic APIs producer
View company profile

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    Product CGMP (+)-Cloprostenol (sodium salt)

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Cayman Pharma s.r.o resources (13)

  • Cayman Chemical Receives CEP for Latanoprost API from EDQM

    News Cayman Chemical Receives CEP for Latanoprost API from EDQM

    ANN ARBOR, MI, SEPTEMBER 12, 2023—Cayman Chemical, a world leader in the manufacture of prostaglandins for both research use and as active pharmaceutical ingredients (APIs), has been granted a Certification of Suitability to the monographs of the European Pharmacopoeia (CEP) by the European Directorate for the Quality of Medicines and HealthCare (EDQM) for its latanoprost API, effective August 28th, 2023. Cayman Chemical is the first company in the USA to receive a CEP for latanoprost.
    18 Oct 2023
  • Cayman Pharma cGMP API Manufacturing

    Brochure Cayman Pharma cGMP API Manufacturing

    This leaflet presents cGMP API portfolio of Cayman Pharma and Cayman Chemical.
  • Cayman Chemical Contract Services

    Brochure Cayman Chemical Contract Services

    This leaflet presents services offered by Cayman Chemical.
  • Cayman Pharma and Cayman Chemical - Opthalmics

    Brochure Cayman Pharma and Cayman Chemical - Opthalmics

    This leaflet presents detailed overview of cGMP prostaglandins used for glaucoma treatment manufactured by Cayman Pharma and Cayman Chemical.
  • Cayman Chemical - Psychedelics

    Brochure Cayman Chemical - Psychedelics

    This leaflet presents detailed overview of cGMP psychedelic APIs manufactured by Cayman Chemical.
  • Cayman Pharma - Vascular APIs

    Brochure Cayman Pharma - Vascular APIs

    This leaflet presents detailed overview of cGMP prostaglandins used for pulmonary hypertension treatment manufactured by Cayman Pharma
  • Cayman Pharma - Veterinary APIs

    Brochure Cayman Pharma - Veterinary APIs

    This leaflet presents detailed overview of cGMP prostaglandins used in veterinary medicine and manufactured by Cayman Pharma
  • API Manufacturing

    Brochure API Manufacturing

    Learn more about the importance of process understanding and Cayman's commercial API production
  • API Contract Services

    Brochure API Contract Services

    Cayman Chemical’s API Services group helps companies turn their new drug ideas into reality. The Cayman advantage offers the flexibility to support your project, allowing you to create a customized service to meet your needs.
  • Ophthalmology APIs

    Brochure Ophthalmology APIs

    The natural compound prostaglandin F2α (PGF2α) activates signaling pathways in the eye that reduce intraocular pressure (IOP). A family of PGF2α analogs, including bimatoprost, latanoprost, tafluprost, and travoprost, have been developed, and these compounds are more potent than PGF2α itself in lowering IOP and have fewer side effects. Moreover, they are known to be safe and effective when used in the treatment of glaucoma.
  • Psychedelic APIs

    Brochure Psychedelic APIs

    Psychedelics are emerging as promising therapies in the treatment of various neurological and psychiatric conditions. Though psychedelics are controlled substances in most countries, clinical trials exploring the use of psychedelics are underway. The US FDA has granted breakthrough therapy status for the use of psilocybin in major depressive disorder and treatment-resistant depression, for which it has shown to be safe and effective. It may also have potential in the treatment of anxiety, substance use disorder, cluster headaches, as well as psychological distress associated with end-of-life.
  • Vascular APIs

    Brochure Vascular APIs

    Each prostaglandin (PG) evokes distinct physiological effects through specific cell surface receptors. PGI2 (prostacyclin) promotes smooth muscle relaxation and inhibits platelet activation through the IP receptor. Agonists of IP, including epoprostenol, iloprost, and treprostinil, are effective in relaxing pulmonary arterial smooth muscle and are used in the treatment of pulmonary hypertension.
  • Veterinary APIs

    Brochure Veterinary APIs

    A stable and potent analog of prostaglandin F2α (PGF2α), cloprostenol is used in the care of domestic mammals to induce luteolysis, initiate estrus, and synchronize estrus cycles. Both the racemic and active isomer are also used to induce parturition, terminate abnormal and normal pregnancies, and treat chronic endometriosis and ovarian luteal cysts.