Highly Potent APIs (HPAPIs) CDMO Services

ESTEVE CDMO provides integrated spray drying development and manufacturing services for complex small-molecule programs, from early feasibility through GMP manufacturing and commercial supply.

Our spray drying platform combines API-sparing strategies, predictive modeling, rapid analytical feedba...

This strategic move allows ESTEVE CDMO (actively operating under the Esteve Química brand) a physical presence in the United States, expanding its contract development and manufacturing solutions for innovative small-molecule active pharmaceutical ingredients (APIs) across the entire drug development lifecycle from pre-clinical to commercial manufacturing.

Choosing a Spray Drying Manufacturer: Why Flexibility and Customizability Matter.The spray drying of active pharmaceutical ingredients (APIs) is a technology...

Esteve was honoured with the 2025 CDMO Leadership Award in the Small Molecule API – Global category and also recognized with the Champion Award, delivered to the CDMO with the highest ranking in this category.
These prestigious recognitions reflect not only our commitment to excellence in pharmaceutical development and manufacturing but also the trust and collaboration of our clients and partners worldwide. We would like to extend our deepest gratitude to everyone who has made this journey possible. ​And above all, a heartfelt thank you to our incredible team at who has provided the opportunity of receiving such remarkable achievements ESTEVE. You are the driving force behind our success.​​

This award is the result of a shared effort, a collective commitment to delivering value, innovation, and better health for people everywhere. Let's keep advancing health together!​

Spray Drying - Adding value to your API. Esteve Quimica constantly strives to offer the best-in-class service to its customers. Understanding customer spec...

Spain-headquartered CMO Esteve expands its manufacutring capacity in plants in Girona, Spain to increase global API offerings with advanced technological solutions, through a weighty investment of €100 million. 

ESTEVE CDMO industrialized and delivered 20 metric tons of API in nine months, with manufacturing starting just 70 days after project award. Success was driven by coordinated multi-site execution, a harmonized quality system, a global supply chain and close collaboration with the customer.

Read the full case study to discover how the program was delivered at speed and scale.

While people tend to think worldwide supply chain issues or supply conflicts impacting specific markets affect all companies in a distressed field equally, regardless of efforts to mitigate the negative occurrence’s impact, this simply is not true. Anticipatory planning and established supply disruption mitigation plans often enable market access before competitors — in advance of suffocating demand — while mitigating or eliminating concomitant supply chain problems like cost or timeline overruns, as well as lapses in material quality or security of supply.

The spray drying of active pharmaceutical ingredients (APIs) is a technology widely used to enhance bioavailability for poorly soluble materials, dry heat-sensitive pharmaceuticals, and perform particle engineering. Spray drying is a process in which a solution of API and a polymer are rapidly dried to produce an amorphous powder. The fact that it allows for the customization of powder characteristics, particularly solubility, renders it a preferential technology for the increasing number of molecules that have become pharmaceutical candidates in recent years.

Quality and compliance might be associated with bottlenecks and the creation of complexity, but it does not have to be like this. When a CMO has the right quality culture, knowledgeable quality personnel are involved in the earliest phases of customer projects and everyone upholds a customer-centric vision; a reliable, flexible, and transparent quality system is the norm.