Methyl tosylate-d3

Bromocyclopentane-d₉ is a high-purity deuterated alkyl bromide widely used as a versatile building block in the synthesis of stable isotope-labeled pharmaceuticals, intermediates, and analytical reference standards. It enables the efficient introduction of a deuterated cyclopentyl group into complex organi...

Deucravacitinib is a first-in-class, oral, allosteric tyrosine kinase 2 (TYK2) inhibitor that selectively targets the enzyme's regulatory domain to suppress inflammatory cytokine pathways (IL-23, IL-12, Type I IFNs) while sparing JAK1–3. Approved for the treatment of moderate-to-severe plaque psoriasis, it...

Deutetrabenazine is a first-in-class, orally bioavailable deuterated vesicular monoamine transporter 2 (VMAT2) inhibitor approved for the treatment of chorea associated with Huntington’s disease and tardive dyskinesia. 

Deutivacaftor  is an orally active, deuterated cystic fibrosis transmembrane conductance regulator (CFTR) potentiator designed to improve salt and water transport across cell membranes. As a deuterium-substituted analogue of ivacaftor, it utilizes targeted carbon-deuterium bonds to resist CYP3A-mediat...

Methylboronic Acid-d₃ (CD₃B(OH)₂) is a high-purity deuterated organoboron building block widely used in the synthesis of stable isotope-labeled pharmaceuticals, advanced intermediates, and analytical reference standards. It is an essential reagent for Suzuki–Miyaura cross-coupling reactions, enabling the e...

Methyl iodide-d₃ (CD₃I) is a high-purity deuterated methylating reagent widely used in the synthesis of stable isotope-labeled pharmaceuticals, intermediates, metabolites, and analytical reference standards. It enables the efficient incorporation of a deuterated methyl (–CD₃) group into complex organic mol...

Methylamine-d₃ Hydrochloride serves as a key deuterated building block for introducing a CD₃-labeled methylamine moiety into complex organic molecules. It is extensively used in the preparation of deuterated drug candidates, impurities, and metabolites, including compounds such as: Deucravacitinib-d₃ ...

Tert-Butanol-d₁₀ ((CD₃)₃COD) is a high-purity deuterated alcohol widely used as a solvent and isotope-labeled building block for the synthesis of stable isotope-labeled pharmaceuticals, intermediates, and analytical reference standards. It provides an efficient source of deuterium for the preparation of de...

2-(3,4-bis(methoxy-d3)phenyl)ethan-1-amine is an advanced deuterated intermediate essential for the commercial synthesis and manufacturing of Deutetrabenazine (API)

Lisdexamfetamine Dimesylate is a central nervous system (CNS) stimulant active pharmaceutical ingredient (API) and prodrug indicated for the treatment of Attention Deficit Hyperactivity Disorder (ADHD) and binge eating disorder (BED). Enzymatically hydrolyzed in red blood cells to release active dextroamph...

Specialised in Deuterium Chemistry, Clearsynth Manufactures Deuterated Reagents, Deuterated Intermediates and Deuterated APIs (such as Deutetrabenazine, Deuruxolitinib, Deutivacaftor, Deucravacitinib, Donafenib)

Production capacity from mg to tons scale.

Our key reagents are Benzene D...

Clearsynth is a globally trusted partner for reference standards and research chemicals. We offer over 3,000 nitrosamine impurities, 5,000+ stable isotopes, and 10,000+ drug impurities, encompassing a vast portfolio of more than 325,000 products serving various industries, including pharmaceuticals, clinic...

Clearsynth Labs Limited is a technology-based, research-driven, innovation-led enterprise specializing in deuterium chemistry and stable isotopes. Headquartered in Mumbai, with an R&D center in Hyderabad and a CDMO facility in Karnataka, alongside operations in Canada and the USA, we deliver solutions from milligram-scale R&D to multi-ton manufacturing. Our expertise spans deuterated APIs, intermediates, impurities, and reference standards. Backed by strong IP and 350+ scientists, we partner with innovators and generics across CDMO and CMO segments, committed to precision, quality, and advancing next-generation isotopic solutions for global pharmaceutical needs.