Pralatrexate

Steroidogenesis inhibitor API that blocks 11-beta-hydroxylase and is used to control hypercortisolism in Cushing syndrome.

Synthetic anabolic-androgenic steroid API used in selected conditions requiring promotion of weight or lean-tissue gain.

Bisphosphonate API that inhibits osteoclast-mediated bone resorption and is used in hypercalcemia and other high-turnover bone disorders.

Multitargeted antifolate antineoplastic API used in chemotherapy for mesothelioma and selected non-small-cell lung cancers.

Oral antifibrotic API used to slow disease progression in idiopathic pulmonary fibrosis.

CXCR4 antagonist API used to mobilize hematopoietic stem cells into peripheral blood for collection before transplantation.

Class IC antiarrhythmic API that blocks cardiac sodium channels and is used for selected atrial and ventricular arrhythmias.

Selective serotonin 5-HT4 receptor agonist API with prokinetic activity used for chronic constipation.

Topical keratolytic and antiseptic active used in dermatological preparations and as a pharmaceutical intermediate.

Nitrogen-containing bisphosphonate API that reduces bone resorption and is used in osteoporosis and related bone disorders.

Lysine salt of carbocisteine used as a mucoregulating and mucolytic active in respiratory formulations.

Selective serotonin reuptake inhibitor API used in antidepressant and anxiety-disorder therapies.