SODIUM STEARYL FUMARATE

Sodium Stearyl FUMARATE (SSF). It is a tablet lubricant for use in ODT tablets, in effervescent formulas, or in formulas where the active incompatible with magnesium stearate. It is an inert, less hydrophobic tablet lubricant than magnesium stearate.  Tablets made with SSF exhibit less sensitivity to variations in blending time and lubricants levels and have superior hardness characteristics compared to tablets produced with magnesium stearate. Compatibility studies comparing SSF to Mag. Stearate showed that SSF was superior with respect to impact on tablet hardness, ejection forces, friability and disintegration.  The compatibility of blends was reduced when using magnesium stearate. Ejection forces and friability were also higher for tablets made using magnesium stearate.  The disintegration times were longer for magnesium stearate and varied with level