Urokinase

Urokinase, an enzyme protein isolated from healthy human urine or obtained from human kidney tissue culture, is composed of two parts with molecular weights of 33000 (LMW-tcu-PA) and 54000 (HMW-tcu-PA). It is mainly used as a thrombolytic agent and acts directly on the endogenous fibrinolytic system. It can catalytically cleave plasminogen into plasmin, which can not only degrade fibrin clots, but also degrade fibrinogen, coagulation factor Ⅴ and coagulation factor Ⅷ in blood circulation, so as to play a thrombolytic role. It has a quick and good effect on newly formed thrombosis, and can also improve the activity of vascular ADPase, inhibit ADP-induced platelet aggregation, and prevent thrombosis. After the intravenous infusion, the patient's plasmin activity was markedly increased, and a few hours after the drug was stopped, the plasmin activity returned to the original level.