Biocatalysis Solutions

Product description

Biocatalysis Solutions:  Biocatalysts are essential tools in chemical synthesis, particularly in the synthesis of pharmaceutical and fine chemical targets. As highly selective catalysts, they offer a direct and simple way to synthesise complex achiral and chiral compounds. The application of biocatalysts in the pharmaceutical and fine chemical industries continues to grow as it moves from the domain of specialised technology to mainstream methodology. This movement has been facilitated by the increasing commercial ‘off-the-shelf’ availability of biocatalysts. Almac has heavily invested in this area to secure the supply of selectAZymeTM biocatalysts for clients’ non-GMP and GMP manufacturing projects.

Our Biocatalysis Group
Consisting of computational, molecular and micro biologists, enzymologists, organic chemists and analysts, the group has demonstrated expertise in gene identification, expression, enzyme evolution, fermentation, enzyme production and biotransformation scale-up.  Expertise ranges from enzyme production to the synthesis of complex chiral APIs from mg-tonne scale.

Our team is closely linked to the process chemistry and manufacturing chemistry groups, where enzyme discovery and development is integrated with screening and route definition. Each member of the team brings expertise to complex processes procedures and can rapidly implement an enzymatic process to significantly improve the yield and timelines of a multi-step synthesis.

In addition, Almac has recently acquired Arran Chemical Company which significantly increases our scale (a range of reactors up to 6,300L and total capacity of up to 45m3).  The new combined business will integrate Biocatalysis technology with large scale intermediates manufacture. The bespoke facility offers a full range of scales including kg lab, multi-purpose pilot plant and manufacturing plant.

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