Plasticell’s Massively Parallel Approach is Set to Transform the Regenerative Medicine Research Landscape

UK stem cell biotech pioneer Plasticell has announced the publication of scientific research which demonstrates how the company’s innovative high throughput 'Combinatorial Cell Culture' (CombiCult) technology allows a single scientist to perform 10,000 stem cell biology experiments in parallel. The scientific paper ('Directed differentiation of embryonic stem cells using a bead-based combinatorial screening method')points to the potential of high throughput technologies such as “Combinatorial Cell Culture” to accelerate painfully slow biomedical research, which has hampered the development of new therapies ever since human embryonic stem cells were developed in 1998.

Plasticell’s cutting edge technology allows the discovery of improved methods to create chosen human cell types from stem cells, a critical step in the discovery of regenerative medicines to treat conditions such as diabetes, Parkinson’s disease and multiple sclerosis. The 10,000 individual experiments would have required around 200 years to complete back-to-back.

Chris Mason, Professor of Regenerative Medicine Bioprocessing at UCL, whose research group conducted external validation of the technology commented: "Discovery of robust methods to differentiate stem cells remains a serious bottleneck for the industry. This is a major reason why only two pluripotent stem cell therapies have progressed to clinical trials despite the spending of many hundreds of millions of dollars on pluripotent stem cell translation. The unique CombiCult technology can dramatically increase research productivity, significantly cutting costs whilst accelerating the development of innovative therapies for serious medical conditions."

Dr Yen Choo, Plasticell’s Executive Chairman and senior author of the scientific paper, added: "Optimising laboratory methods to obtain affordable, industrialised cell manufacturing protocols is absolutely key to the development of cell therapies. The paper describes a study in which we used combinatorial screening to obtain a 250-fold reduction in cell bioprocessing costs, through a 50-fold increase in cell yield accompanied by a five-fold reduction in reagent costs via the use of cell culture media comprising small molecule drugs."

The paper also demonstrates use of CombiCult technology to produce large numbers of rare adult stem cells that maintain and repair various organs of the body such as the brain and heart. "We believe progenitor cells are key to the discovery of new drugs that regenerate specific tissues of the human body in response to injury, disease or ageing," added David Phillips, Partner at SR One, the corporate venture arm of the pharmaceutical company GSK, which is backing Progenitor Therapeutics, a Plasticell spin-out company that uses CombiCult to develop drug-based regenerative medicines.