(3R,4S,5R,6R)-3,4,5-tris(trimethylsilyloxy)-6-((trimethylsilyloxy)methyl)-tetrahydropyran-2-one

32384-65-9

(3R,4S,5R,6R)-3,4,5-Tris(trimethylsilyloxy)-6-((trimethylsilyloxy)methyl)tetrahydropyran-2-one (CAS No. 32384-65-9) is a high-purity pharmaceutical intermediate with a molecular formula of C₁₈H₄₂O₆Si₄ and a molecular weight of 466.87 g/mol. It appears as a colourless to slight yellowish clear liquid, with a density of approximately 0.97 g/cm³ and a boiling point around 417°C. This compound is soluble in solvents like hexane, n-heptane, Dichloromethane, THF, Toluene, methanol, DMF and DMSO and should be stored under inert gas (nitrogen or argon) at 2–8°C to maintain stability. It serves as a crucial intermediate in the synthesis of sodium-glucose co-transporter 2 (SGLT2) inhibitors, including Dapagliflozin, Empagliflozin, and Canagliflozin, which are vital for managing type 2 diabetes by regulating glucose reabsorption in the kidneys. Additionally, its trimethylsilyl groups make it valuable as a protecting agent in organic synthesis, preventing unwanted reactions at hydroxyl sites.

Prompt Delivery; Quality Service; Critical Intermediate for SGLT2 Inhibitors, High Purity and Quality, Versatile Protecting Group, Stable under proper storage, Essential for Antidiabetic Drug Development, High Demand in Pharmaceutical Industries, Scalable Productions, Compliance with Quality Standards

India

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