Cholestyramine Resin USP (Doshion P 550 USP)

DOSHION P550 is Cholestyramine, a strong base type 1 anion exchange resin powder with a polystyrene matrix and quaternary ammonium functional groups. This is a pharmaceutical grade product which is an active drug for the treatment of a specific medical condition. The normal function of bile salts, secreted by the gall bladder into the intestines, is to emulsify fats and other lipids in order to promote their enzymatic hydrolysis and thereby enable transfer to the liver, via the venous circulation or the portal system. The bile salts, mainly sodium glycocholate, with smaller amounts of sodium taurocholate, act as surfactants by virtue of their dual lipophile/hydrophile character. In obstructive jaundice, an excess of these materials is present in the gastro-intestinal tract, increasing the concentration of cholesterol in the bloodstream, with accompanying hazard to the cardio-vascular system. Here and in other conditions of high blood cholesterol, it has been found that oral administration of Colestyramine, which has a high affinity for the glycocholate and taurocholate ions is effective in reducing the blood cholesterol level.DOSHION P550 fully complies with the U.S.Pharmacopeia where it is listed under the name Colestyramine. This product is registered with the Food and Drug Administration and has a up to date Drug Master File with the FDA .

Application:

• Cholesterol reduction
• Control release of Diclofenac Potassium
• Taste masking of bitter drugs