Ionizable Lipid Screening and Formulation Optimization
Product Description
NOF CORPORATION
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Country/Region:United States
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On CPHI since:2018
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Employees:1000 - 4999
Company types
Categories
NOF CORPORATION
-
Country/Region:United States
-
On CPHI since:2018
-
Employees:1000 - 4999
Company types
More Products from NOF CORPORATION (6)
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Product Acetal-Linkage Releasable PEGs
NOF has developed releasable PEG derivatives that have cleavable acetal linkers in physiological environment(pH7.4). The PEGylated drug by releasable PEGs release native drug through hydrolysis and 1,4-elimination.The release rate of bioactive substance can be controlled with linker structures. -
Product Activated PEG-Lipids for Targeting Lipid Nanoparticles
For specific delivery, nanoparticles modified with ligands are widely used.Conventional modifying agents, such as activated PEG-phospholipids, have an ioniccharge.It is complicated to apply them to lipid nanoparticles (LNP), as they have anegative impact on a charge and stability of LNP.NOF newly developed... -
Product COATSOME SS Series_Novel Lipid Nanoparticle Platform
We have newly developed COATSOME® SS Series foreffective intracellular delivery and lower toxicity.COATSOME® SS Series contains dual sensing motifs thatcan respond to the intracellular environment; tertiaryamines respond to an acidic compartment (endosome/lysosome) for membrane destabilization, and disulfi... -
Product Custom Lipid Synthesis for Pharmaceutical Applications
NOF CORPORATION has manufactured and supplied high purity GMP-grade phospholipids and other lipid derivatives to pharmaceutical companies worldwide since the early 1990s. These are suitable for lipid emulsion, liposome,and lipid nanoparticle (LNP / targeted LNP)formulations. -
Product High purity PEG Diacylglycerols for Lipid Nanoparticles
NOF has succeeded in developing PEG lipids (diacylglycerol-type PEG lipids with various PEG molecular weights and acyl chain lengths for lipid nanoparticle (LNP)applications) with higher purity and extremely low levels of impurities compared to PEG lipids available from other companies. Leveraging our year... -
Product Pendant Type Monodisperse PEG linker
NOF has developed novel monodisperse PEG linkers that have pendant-like structure. The pendant type PEG linkers have two monodisperse PEG chains with two different functional groups. The pendant type PEG linkers can improve hydrophilicity of ADCs by effectively masking hydrophobicity of payloads.
