Pendant Type Monodisperse PEG linker

NOF has developed releasable PEG derivatives that have cleavable acetal linkers in physiological environment(pH7.4). The PEGylated drug by releasable PEGs release native drug through hydrolysis and 1,4-elimination.The release rate of bioactive substance can be controlled with linker structures.

For specific delivery, nanoparticles modified with ligands are widely used.Conventional modifying agents, such as activated PEG-phospholipids, have an ioniccharge.It is complicated to apply them to lipid nanoparticles (LNP), as they have anegative impact on a charge and stability of LNP.NOF newly developed...

We have newly developed COATSOME® SS Series foreffective intracellular delivery and lower toxicity.COATSOME® SS Series contains dual sensing motifs thatcan respond to the intracellular environment; tertiaryamines respond to an acidic compartment (endosome/lysosome) for membrane destabilization, and disulfi...

NOF CORPORATION has manufactured and supplied high purity GMP-grade phospholipids and other lipid derivatives to pharmaceutical companies worldwide since the early 1990s. These are suitable for lipid emulsion, liposome,and lipid nanoparticle (LNP / targeted LNP)formulations.

NOF has succeeded in developing PEG lipids (diacylglycerol-type PEG lipids with various PEG molecular weights and acyl chain lengths for lipid nanoparticle (LNP)applications) with higher purity and extremely low levels of impurities compared to PEG lipids available from other companies. Leveraging our year...

NOF CORPORATION and Phosphorex collaborate to supply Ionizable Lipid Screening and Formulation Optimization using NOF’s proprietary Ionizable lipids, COATSOME® SS to its clients. NOF CORPORATION manufactures and supplies highly purified lipids derivatives (COATSOME® Series) suitable for lipid emulsion...