loVol®

  • loVol® 1
  • loVol® 2
Product Description

The loVol®  is a specialized system engineered for low-volume solubility and dissolution testing. Designed for early-stage drug development and formulation screening, loVolr evaluates APIs, powder mixtures, granules, coated pellets, and finished oral dosage forms under both constant pH and dynamic pH gradient conditions. 

It supports both constant pH and pH-gradient experiments while using only up to 25 mL per vessel, reducing reagent costs and better mimicking physiological conditions for early-stage development. The loVol® offers precise control of temperature, stirring, and pH in every experiment. The integrated pHysio- grad enables automated pH adjustment. .

Read more Show less

Physiolution Polska sp. z o. o.

  • Country/Region:
    Poland
  • Founded:
    2009
  • On CPHI since:
    2026
  • Certificates:
    1
  • Employees:
    1 - 24
Company types
Biopharmaceutical company
Primary activities
Biopharmaceutical
Laboratory Services
Laboratory, Analytical, Biotechnology Equipment
View company profile
Categories
more categories Show less
Specifications
  • Details
    loVol® is a compact, low-volume system for solubility and biopredictive dissolution  testing of APIs, powder blends, granules, coated pellets, and finished dosage forms.
  • Selling Points
    Product Features; Product Performance; Quality Service; Key Advantages of loVol® are:
    - Physiological Relevance: Operating at low working volumes (up to 25 mL) closely replicates in vivo gastrointestinal conditions, delivering more predictive dissolution data.

    - Cost & Media Efficiency: Significantly reduces reagent and media consumption, lowering operational costs and minimizing environmental impact.

    - System Configuration & Functionality

    - 11-Vessel Architecture: Features 11 vessels per run—8 configured for simultaneous pH-controlled testing and 3 reserved for support (e.g., blanks or media concentrates).

    - Precise Parameter Control: Enables real-time monitoring and adjustments of vessel temperature, stirring speed, and pH throughout the experiment 

    - Bicarbonate Buffer Compatibility: Integrates the pHysio-grad® automatic pH controller to run dynamic, biorelevant bicarbonate buffer profiles.

    - Flexible Analytics & Sampling (UV-Vis or HPLC)
  • Model
    Hybrid Device-as-a-Service (device provisioning and scientific support))
  • Measured In
    piece
More specifications Fewer specifications
Sales Markets
Show more Show less

Physiolution Polska sp. z o. o.

  • Country/Region:
    Poland
  • Founded:
    2009
  • On CPHI since:
    2026
  • Certificates:
    1
  • Employees:
    1 - 24
Company types
Biopharmaceutical company
Primary activities
Biopharmaceutical
Laboratory Services
Laboratory, Analytical, Biotechnology Equipment
View company profile

More Products from Physiolution Polska sp. z o. o. (6)

  • Advanced Modular Platform (AMP™ )

    Product Advanced Modular Platform (AMP™ )

    AMP™ (Advanced Modular Platform) is the first system to deliver precise, customizable simulations of dynamic in vivo conditions. Built around a universal core system with interchangeable test modules, AMP™ realistically mimics gastrointestinal transit by combining:

    • Dynamic mechanical and phys...
  • Compass®

    Product Compass®

    Compass® is a Python-based software that predicts in vivo similarity of immediate-release oral dosage forms by combining semi-mechanistic modeling with user-provided dissolution and pharmacokinetic data.
    Compass® fits a modified Noyes–Whitney model, simulates plasma concentration–time pr...
  • DoSampler

    Product DoSampler

    The DoSampler is a versatile autosampler designed to complement pHysio-grad® and AMP systems, or operate in standalone mode. 

    It enables precise, automated sampling into HPLC vials or glass tubes using high-accuracy syringe pumps.With support for up to 12 channels and the ability to collect up ...
  • Oral Delivery Feasibility Screening

    Product Oral Delivery Feasibility Screening

    Our experimental protocols are designed to simulate the stressors of the GI environment, providing a high-resolution assessment of molecular integrity. Key services include:

    pH-Dependent Kinetic Stability: Quantitative assessment of API chemical stability across a physiological range of ...
  • pHysio-grad

    Product pHysio-grad

    The pHysio-grad® device: 
    - Can precisely monitor and adjust the pH value of commonly used hydrogen carbonate buffers the pH adjustment in the range of pH 5.5 to 8.3 with a maximum deviation of ± 0.02 pH units.

    - Utilizes pure CO2 and inert gases for simulation of intestinal condi...
  • PhysioCell

    Product PhysioCell

    Our PhysioCell: 

     - simulates crucial conditions of the upper GIT and is based on three-compartmental flow-through construction,


    - features simulation of: gastric motility, constant or variable kinetics of the gastric emptying of non-caloric liquids, temperature gradients of the...