PEG Linkers for Targeted Protein Degraders (TPD), PROTACs, DACs, and LYTACs

Jenkem technology co ltd offers polyethylene glycol derivative which includes peg (amine) 2, hcl salt. It is a peg-modified monofunctional peg in a stable ligation form of amide, carbamate, urea or secondary amine. The hydrochloride form allows the diamine peg to be present in a stable solid state. The sam...

Jenkem technology co ltd offers polyethylene glycol derivative which includes peg (carboxyl) 2. Contact us for more information.

Jenkem technology co ltd offers polyethylene glycol derivative which includes peg (maleimide) 2. It is a mercapto reactivity with bifunctional peg derivatives that selectively reacts with mercapto groups on the side chain of cysteine. Peg (maleimide) 2 can be mercaptan peg modified in the environment of ph...

Jenkem technology co ltd offers polyethylene glycol derivative which includes peg (succinimidyl carboxymethyl ester) 2. It is high-quality double-peg succinimidyl carboxymethyl ester products with a product replacement rate of ≥95%. Contact us for more information.

Jenkem technology co ltd offers polyethylene glycol derivative which includes peg (thiol) 2. It can selectively react with the sulfur groups on the side chain of cysteine ​​under mild reaction conditions. The same double-functional peg derivatives can be used as cross-linking agents in peg and nano-particl...

Jenkem technology co ltd offers polyethylene glycol derivative which includes peg (vinylsulfone) 2. It is high quality diethylene sulfone peg products with a product replacement rate of ≥90%. Contact us for more information.

Jenkem technology co ltd offers monodisperse polyethylene glycol derivatives which includes pentaethylene glycol monomethyl ether. Contact us for more information.

Jenkem technology co ltd offers monodisperse polyethylene glycol derivatives which includes propionic acid peg12propionic acid. It is a monomolecular and bifunctional peg for amine peg modification that reacts with the amine groups of lysine or n-terminal amines. Monodisperse dipropionate peg is more stabl...

Jenkem technology co ltd offers monodisperse polyethylene glycol derivatives which includes propionic acid peg8 propionic acid. It is a monomolecular and bifunctional peg for amine peg modification that reacts with the amine groups of lysine or n-terminal amines. Monodisperse dipropionate peg is more stabl...

Jenkem technology co ltd offers polyethylene glycol derivatives which includes y-shape (mpeg20k) 2 acetaldehyde. It is a n-terminal modified polyethylene glycol derivative having a branched structure. The y derivatives have a more selective structure than linear polyethylene glycol derivatives because of t...

Jenkem technology co ltd offers polyethylene glycol derivatives which includes y-shape (mpeg20k) 2 alkyne. It is a pegylated reagent that can react with azide-containing molecules. Can be in a mild and simple conditions and rapid reaction with azide groups, with high selectivity and high yield characterist...

Jenkem technology co ltd offers polyethylene glycol derivatives which includes y-shape (mpeg20k) 2 amine. It is having a y-type branch can form a chemical bond having a stable structure such as an amide, a urethane or a secondary amine with a substrate. The aminated hydroxyl groups in the y-nh2 structure a...

JenKem Technology offers large scale GMP manufacture of premium fatty acid side chain products for drug modification, with batch size of 10kg-100kg, with high purity and good lot-to-lot reproducibility. Fatty acid side chains are known to aid in improving patient compliance with increased half-life for Glucagon-like peptide-1 (GLP-1) receptor agonists, which are extensively used in the treatment of type II diabetes and obesity. For example, several drug entities such as tirzepatide, somapacitan, or semaglutide, are modified to incorporate fatty acid side-chains.

JenKem Technology provides large scale GMP manufacture of monodisperse (discrete) PEG linkers for ADCs and for targeted protein degraders (TPD), including PROTACs, DACs, and LYTACs.

We offer a competitive price for kilogram-scale manufacture for our high-purity monodisperse PROTAC PEG linkers with various active groups, E3 ligase ligands, and E3 ligase ligand-linker conjugates, please contact us at [email protected] for a quotation.

JenKem Technology provides large scale GMP manufacture of PEG-lipids, lipids, PEG intermediates for lipid nanoparticles, along with innovative lipid nanoparticle (LNP) formulation services for selective delivery of mRNA and siRNA therapeutics.

Large scale GMP manufacture of lipids (cationic lipids, ionizable lipids, PEG lipids, phospholipids, helper lipids, SORT lipids, and others made-to-order)Development services for innovative lipids (i.e., JK-0315-CA, JK-102-CA, JK-0039, JK-0005), including lipid process development, quality research, CDE/DMF applications. Several China CDE applications and US FDA DMFs already filed for several LNP excipients
Lipid nanoparticles (LNP) formulation development, such as our innovative 3-component LNPs and 5-component LNPs for selective organ targeting
Lipid nanoparticle (LNP) encapsulation services for development of RNA therapeutics
Analytical testing services for Lipid nanoparticles (LNPs), RNA, and LNP-RNA

PEG Products Catalog