ROQUETTE FRERES SA

Kleptose HP and HPB for pharmaceutical applications: parenteral use, syrup oral suspensions. HPBCD increase water solubility and bioavailability.

PEARLITOL® Mannitol pharma range is used as a filler and filler/binder as well as a bulk sweetener. The PEARLITOL® range offers a unique blend of exceptional physical and chemical stability and no hygroscopicity.PEARLITOL® can be used in various oral dosage forms in both pharmaceutical and nutraceutic...

A microcrystalline cellulose with filler-binder properties and a certain capacity to act as a disintegrant.

KLEPTOSE® Betacyclodextrins are efficient solubilisation, stabilization enhancers and taste-masking agents. A full range is available for use in many dosage forms, from solid to liquid.

A physiological sugar used as an active isotonic agent or a carbohydrate energy source in parenteral infusion or injectable therapies.

The new facility will focus on the research of excipients for oral dosage forms, drug delivery systems, nutraceutical APIs and innovative pharma ingredients

Discover the wide range of products by Roquette in Pharmaceuticals and Neutraceuticals

The ramping up of vaccine manufacturing demand amid the COVID-19 pandemic had an initial impact on cell and gene therapy production but the regenerative medicine sector has largely weathered the storm, according to senior industry figures in a recent panel discussion at the CPHI Festival of Pharma virtual event.

Polysorbates are intensively used in biologics formulation as stabilizer due to their propensity to inhibit aggregation at interfaces but possess low intrinsic stability. In this study, the chemical stability of KLEPTOSE® HPBCDs are compared with polysorbates under various stress conditions.

When subjected to heat stress and other chemical stressors – autoclave, light and oxidative stresses – HPBCD remains almost stable while polysorbates show more severe degradation. Further, profiling characterization and degradation analysis reveal that HPBCD chemical structure remains intact while polysorbates undergo significant hydrolytic degradation and oxidation.

Lastly, the physicochemical stability of monoclonal antibody in formulations have been investigated using adalimumab as a model protein. When subjected to light stress, HPBCD-containing formulations show significant decreases in protein aggregation, as well as superior monomer and total protein recovery compared to polysorbate-containing formulations. HPBCD also reduces both agitation and thermal stress-induced protein aggregation and prevents sub-visible particle formation compared to polysorbates.


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Worldwide, people are increasingly health-conscious and aware of the impact of individual lifestyle choices on their health and the health of others. In the latest years, consumers seek more and more transparency from companies through their brand, product manufacturing, and actions that promote well-being for the world around them. While also looking for more affordable, accessible, and personalized product experiences. This session explores the latest news and insight on consumer health, including how pharma engages patients in education and decision-making.

It’s a hard pill to swallow, but medication adherence is a crucial issue today. For oral formulations in pharma and nutraceuticals, taste, appearance, and aroma directly impact patient compliance and consumer experience.
Choosing the right excipients to provide optimum performance while continuing to appeal to patients and consumers alike is critical in bringing finished formulations to market.