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Spin-freezing is a novel technology to solve know batch freeze-drying  issues. This technology enables us to reduce processing time as well as easily detect foreign matters. Also, reconstitution time is significantly reduced. Spin-freezing technology can be leveraged to continuous freeze-drying (Continuous FD) for larger production scale. Feasibility study for Continuous FD using RheaLyo™ Mono Freeze-Dryer as single vial unit (SVU) from RheaVita BV was conducted to demonstrate its benefits on the common issues seen in Batch FD.

Overview products and services by RheaVita (lyophilization)

Continuous spin freeze-drying integrates spin-freezing, primary drying, and secondary drying into a fully continuous process. During spin-freezing, vials are rotated under a controlled gas flow, creating a thin and homogeneous frozen layer along the vial wall. This configuration enhances heat and mass transfer, accelerates sublimation, and has the potential to substantially reduce freeze-drying cycle times while maintaining product quality.

In this context, the R&D Formulation and Analytical Development Laboratory of Thermo Fisher Scientific (Monza, Italy) investigated the application of the RheaVita continuous lyophilization technology to a challenging formulation, in comparison with a conventional lyophilizer.

Data from Astellas.

Data from thermo Fisher

Overview of the automated GMP-Flex continuous, controlled lyophilization technology by RheaVita.

Advancing ADC Lyophilization: The Value of RheaVita’s RheaLyo™ Continuous Freeze-Drying Technology for Antibody–Drug Conjugates (ADCs)

Summary of our products and services.

The Mono freeze-dryer expanded with a BSL-2 option.

Stabilizing mRNA LNPs via controlled continuous freeze-drying