Carboxypeptidase-B(CPB)

Carboxypeptidase-B(CPB)
Product Description

  • Molecular weight: ~34 kDa
  • Optimal pH: 7.5‑9.0 (peak activity around pH 8.0)
  • Inhibition: Activity suppressed by metal chelators such as EDTA; Zn²⁺ can restore/enhance enzyme activity.
Key Applications
  • Biopharmaceutical manufacturing (core use) Critical processing enzyme for production of insulin & insulin analog biosimilars. Together with trypsin, CPB trims residual C‑terminal basic residues from pro‑insulin to generate mature active insulin API.
  • Protein research: Determination of protein C‑terminal sequence; removal of C‑terminal tags for recombinant proteins.
  • Production of therapeutic peptides and antibody‑related downstream processing.

  • GMP‑grade recombinant CPB is widely used in biosimilar facilities for insulin‑class macromolecule drug production.

    Yifan Pharmaceutical Co., Ltd

    • Country/Region:
      China
    • On CPHI since:
      2024
    • Certificates:
      4
    • Employees:
      5000+
    Company types
    Biopharmaceutical company
    CMO/CDMO
    Distributor/Import Export
    Generics/Biosimilars Manufacturer
    Licensee
    Manufacturer/Innovator
    Pharmaceutical company
    Primary activities
    Biopharmaceutical
    Pharmaceutical Company (innovator finished products)
    Specifications
    • CAS Registry Number
      9025‑24‑5
    • Details
      Carboxypeptidase‑B (CPB)

      Carboxypeptidase‑B (CPB) is  specifically hydrolyses peptide bonds and removes basic amino acids (Arginine, Lysine, Histidine) from the C‑terminus of proteins and polypeptides.

    • Selling Points
      GMP FACILITY PRODUCTION
    • Model
      enzyme
    • Measured In
      gram

    Yifan Pharmaceutical Co., Ltd

    • Country/Region:
      China
    • On CPHI since:
      2024
    • Certificates:
      4
    • Employees:
      5000+
    Company types
    Biopharmaceutical company
    CMO/CDMO
    Distributor/Import Export
    Generics/Biosimilars Manufacturer
    Licensee
    Manufacturer/Innovator
    Pharmaceutical company
    Primary activities
    Biopharmaceutical
    Pharmaceutical Company (innovator finished products)

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