Tert-butanol-d10

Ruxolitinib is an orally active, potent, and selective Janus kinase (JAK1 and JAK2) inhibitor. It is indicated for the treatment of myelofibrosis, polycythemia vera, graft-versus-host disease (GvHD), and atopic dermatitis/vitiligo (topical formulation). Manufactured under strict GMP guidelines for use in p...

2-(3,4-bis(methoxy-d3)phenyl)ethan-1-amine is an advanced deuterated intermediate essential for the commercial synthesis and manufacturing of Deutetrabenazine (API)

Acetone-d₆ is a versatile deuterated reagent and solvent designed for stable isotope labeling applications. It is extensively used in the synthesis of deuterated APIs, intermediates, metabolites, and analytical reference standards. Its high isotopic purity ensures reliable deuterium incorporation, making i...

Lisdexamfetamine Dimesylate is a central nervous system (CNS) stimulant active pharmaceutical ingredient (API) and prodrug indicated for the treatment of Attention Deficit Hyperactivity Disorder (ADHD) and binge eating disorder (BED). Enzymatically hydrolyzed in red blood cells to release active dextroamph...

Tert-Butanol-d₉ ((CD₃)₃COD) is a high-purity deuterated solvent and versatile isotope-labeled building block used in the synthesis of stable isotope-labeled pharmaceuticals, intermediates, and analytical reference standards. It enables the efficient incorporation of deuterated tert-butyl groups into target...

Deucravacitinib is a first-in-class, oral, allosteric tyrosine kinase 2 (TYK2) inhibitor that selectively targets the enzyme's regulatory domain to suppress inflammatory cytokine pathways (IL-23, IL-12, Type I IFNs) while sparing JAK1–3. Approved for the treatment of moderate-to-severe plaque psoriasis, it...

Deutivacaftor  is an orally active, deuterated cystic fibrosis transmembrane conductance regulator (CFTR) potentiator designed to improve salt and water transport across cell membranes. As a deuterium-substituted analogue of ivacaftor, it utilizes targeted carbon-deuterium bonds to resist CYP3A-mediat...

Specialised in Deuterium Chemistry, Clearsynth Manufactures Deuterated Reagents, Deuterated Intermediates and Deuterated APIs (such as Deutetrabenazine, Deuruxolitinib, Deutivacaftor, Deucravacitinib, Donafenib)

Production capacity from mg to tons scale.

Our key reagents are Benzene D...

Clearsynth is a globally trusted partner for reference standards and research chemicals. We offer over 3,000 nitrosamine impurities, 5,000+ stable isotopes, and 10,000+ drug impurities, encompassing a vast portfolio of more than 325,000 products serving various industries, including pharmaceuticals, clinic...

Clearsynth is Globally Trusted Partner for Reference Standards and Research Chemicals. An extensive range of 325,000+ products serves various industries such as pharma, clinical research, testing laboratories, etc. We specialize in Innovative Organic Chemistry and synthesis of Unique Complex Molecules, St...

Bromocyclopentane-d₉ is a high-purity deuterated alkyl bromide widely used as a versatile building block in the synthesis of stable isotope-labeled pharmaceuticals, intermediates, and analytical reference standards. It enables the efficient introduction of a deuterated cyclopentyl group into complex organi...

Labelled anaologue of cis-Ambroxol, the cis-isomeric impurity of Ambroxol. cis-Ambroxol is a metabolite Bromhexine.

Clearsynth Labs Limited is a technology-based, research-driven, innovation-led enterprise specializing in deuterium chemistry and stable isotopes. Headquartered in Mumbai, with an R&D center in Hyderabad and a CDMO facility in Karnataka, alongside operations in Canada and the USA, we deliver solutions from milligram-scale R&D to multi-ton manufacturing. Our expertise spans deuterated APIs, intermediates, impurities, and reference standards. Backed by strong IP and 350+ scientists, we partner with innovators and generics across CDMO and CMO segments, committed to precision, quality, and advancing next-generation isotopic solutions for global pharmaceutical needs.