Industry on the brink of a new age of smart pharma manufacturing

27 Sep 2019

Report predicts tomorrow’s biggest industry winners will need to invest now ahead of the curve.

Ahead of P-MEC 2019, the only dedicated pharmaceutical machinery event in Europe this year – co-located with CPhI Worldwide in Frankfurt, 5-7 November – the first ever CPhI Pharmaceutical Machinery Report identifies trends affecting the market. The findings highlight how the changing drugs pipeline and the industry’s drive towards more efficient manufacturing is necessitating new investments in pharma equipment.

Industry on the brink of a new age of smart pharma manufacturing

The evolving R&D pipeline of smaller volume drugs, coupled with advanced technologies that remove scale-up challenges – such as single-use equipment and continuous processing – are not only transforming industry attrition rates, but vastly changing the types of machinery used in pharma manufacturing. Moreover, running alongside this pipeline evolution are newer approaches that reduce the number of steps in process development, making production greener and lowering overall cost. Manufacturing is now at a crucial juncture as push and pull drivers – including newer technologies, changing pipelines and demand for lower cost drugs – combine to significantly alter how drugs will be made in the future. The report predicts we are on the cusp of a new age of smart pharma manufacturing, as equipment is set to take centre-stage in the development of advanced medicines.

P-MEC 2019 itself is testament to this trend. Exhibitor numbers have doubled in a single year to over 150, as the industry shifts its perspective on new technologies from ‘in an ideal world we would’ to ‘we must have these to grow’. In an industry that has often been dependent on legacy systems and undertaking manufacturing in ‘the same way as before’ for fear of encountering any potential regulatory hurdles, this is a seismic shift. Significantly, this potentially has huge implications for the entire supply chain and CPhI Worldwide – the largest pharma event in the world with more than 45,000 attendees – is seeing changes across all parts of the show from contract services to ingredients, packaging and finished dosage drugs.

The report also forecasts how flexibility in product design is now integral to the lifespan of equipment – a consequence of new products often being produced for smaller patient cohorts. For example, new types of delivery systems and dosages, mean new packaging and labelling equipment are needed that can adjust to these individual dosage forms.

Reflecting industry drivers, the agenda at P-MEC 2019 explores the implications of patient centricity, evolving equipment for an eco-friendly age, and how new devices used in the biologics industry are affecting equipment considerations and the implications for filling machines.

In another key trend, regulators are striving to make manufacturing processes increasingly standardized and controlled – with technologies that improve quality risk-based methodologies (QRM), Quality by Design (QbD), process analytical technology (PAT) and continuous manufacturing encouraged.

A potential implication of seeking greater control in process methods will be the need for an increased use of real-time monitoring. Significantly, methods from raman and infrared spectroscopy, chromatographic separation to faster technologies such as ultra-performance liquid chromatography (UPLC) or ultra-high performance LC (UHPLC) are proliferating alongside nuclear magnetic resonance (NMR). However, the big challenge that continues to remain is how to build these into commercial production for real-time analysis in enclosed systems, single use technologies, and continuous rigs.

Finally, the report ponders how digital technologies may improve production and machinery as an ‘unknown variable’. For example, the impact that digital technologies will play in reducing downtime and increasing process efficiency through AI. One solution could see the use of connected machines to reduce the need for pharma customers to audit contract manufacturers or ingredient suppliers in person – with real-time product updates supplied automatically, essentially a natural evolution of PAT guidelines.

Orhan Caglayan, Brand Director - CPhI Worldwide & P-MEC, said: “From the optimization of old legacy manufacturing sites to the increased use of testing facilities and equipment, there is genuine excitement around the pharmaceutical machinery industry. This is mirrored by a 50% increase in exhibitors at this year’s P-MEC event, with over 150 confirmed exhibitors so far. What’s more, P-MEC is taking place in Frankfurt, Germany – a hub of manufacturing and Europe’s largest pharma market – and it’s the only pharmaceutical machinery exhibition this year in Europe. So it’s an unmissable opportunity for any company looking to explore the latest technologies to transform the way they work both today and in the future.”

Read More

Related news

Connectivity, customization and sustainability driving packaging and drug delivery in 2020

Connectivity, customization and sustainability driving packaging and drug delivery in 2020

4 Dec 2019

Pharmapack 2020 gathering top specialists and pioneers to exchange their vision on best strategies to tackle key challenges.

Read more 
Worldwide event predicts global pharma trends for 2020

Worldwide event predicts global pharma trends for 2020

27 Nov 2019

Content sessions identify value-added medicines, preventive drugs, early diagnostics and patient experience as some of the trends for the year ahead.

Read more 
India pharma forecast to grow strongly in 2020

India pharma forecast to grow strongly in 2020

22 Nov 2019

The rise in exports growth potential is believed to be in response to concerted reforms by the CDSCO and industry quality improvements in the last few years.

Read more 
Winners of the 16th Pharma Awards

Winners of the 16th Pharma Awards

11 Nov 2019

Companies and individuals from across the whole pharma supply chain recognised for their excellence and commitment.

Read more 
CDMOs to benefit from rising BTDs, orphan drugs and fast track status therapies

CDMOs to benefit from rising BTDs, orphan drugs and fast track status therapies

8 Nov 2019

But personalized medicines will require new logistics and manufacturing systems.

Read more 
Europe predicted to surpass the US in biologic manufacturing capacity by 2023

Europe predicted to surpass the US in biologic manufacturing capacity by 2023

6 Nov 2019

Demand for biological manufacturing is growing faster than capacity growth.

Read more 
China on course for 'massive' bio capacity shortfall

China on course for 'massive' bio capacity shortfall

4 Nov 2019

A shortage of qualified personnel may be a drag factor in cell and gene therapies; in China 100,00L of capacity will need to be added every year to meet bio demand.

Read more 
German pharma benefiting from a Brexit boost?

German pharma benefiting from a Brexit boost?

24 Oct 2019

Germany establishes itself as Europe's leading pharma market in 2019.

Read more 
The talk of the show?

The talk of the show?

23 Oct 2019

Outsourcing, biologics, generics and patient compliance look set to get tongues wagging at this year's CPhI WW.

Read more 
‘FDA should withdraw ANDAs’ says expert

‘FDA should withdraw ANDAs’ says expert

21 Oct 2019

CPhI Worldwide's Annual Report suggests repeat offenders of regulatory infringements should be barred from importing into the US.

Read more