Oral Delivery Feasibility Screening

Oral Delivery Feasibility Screening
Product Description

Our experimental protocols are designed to simulate the stressors of the GI environment, providing a high-resolution assessment of molecular integrity. Key services include:

pH-Dependent Kinetic Stability: Quantitative assessment of API chemical stability across a physiological range of pH values to identify degradation pathways.Enzymatic Degradation Profiling: Evaluation of API resilience in the presence of specific gastric and intestinal proteases and lipases.Simulated 

Gastrointestinal Transit Modeling: Calculation of API decomposition rates under dynamic fasted and fed state conditions, accounting for varying levels of physiological complexity.Critical Parameter Identification: Determination of specific physicochemical factors (e.g., pH, ionic strength, bile salts, buffering capacity) that compromise chemical stability or pharmacological potency. 

Assays: Development of physiology-driven assays

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Physiolution Polska sp. z o. o.

  • Country/Region:
    Poland
  • Founded:
    2009
  • On CPHI since:
    2026
  • Certificates:
    1
  • Employees:
    1 - 24
Company types
Biopharmaceutical company
Primary activities
Biopharmaceutical
Laboratory Services
Laboratory, Analytical, Biotechnology Equipment
View company profile
Categories
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Specifications
  • Details
    The successful development of oral medicinal products necessitates a comprehensive understanding of molecular and biomolecular stability within the highly variable physicochemical enviroment of the gastrointestinal tract. Physiolution provides a specialized suite of analytical methodologies designed to evaluate the suitability of APIs for oral delivery and to identify critical factors impacting their chemical stability and biological activity by providing a unique Biorelevant Analytical Framework.
  • Selling Points
    Product Features; Product Performance; Prompt Delivery; Quality Service; Reputation
  • Model
    Service-as-a-Product (SaaP)
  • Supplied from
    Poland
  • Measured In
    Set
More specifications Fewer specifications
Sales Markets
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Physiolution Polska sp. z o. o.

  • Country/Region:
    Poland
  • Founded:
    2009
  • On CPHI since:
    2026
  • Certificates:
    1
  • Employees:
    1 - 24
Company types
Biopharmaceutical company
Primary activities
Biopharmaceutical
Laboratory Services
Laboratory, Analytical, Biotechnology Equipment
View company profile

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