Peptides

Peptides Companies (32)

Peptides News

Peptides Products (83)

  • Product Atosiban Acetate Injection

    Atosiban is an inhibitor of the hormones oxytocin and vasopressin. It is used as an intravenous medication as a labour repressant to halt premature labor. Atosiban Acetate Injection is indicated to delay immine...
  • Product Peptide and Protein Technology

    Almac’s peptide and protein technology offering is a key component within our suite of services.  We offer a complete range of peptide and protein services from catalogue products through to GMP manufacture from early phase to commercial launch.  We have a proven track record in high quality supply,...
  • Product Oligonucleotides

    Asymchem’s oligonucleotide technology platform provides clients with full services in drug substance, from process development through GMP manufacturing, and drug product, from preformulation development through fill-finish. The process chemistry, analytical, formulation, and regulations teams collaborate to ...
  • Product 50L PHARMA JACKETED GLASS REACTORS DN400

    Complete jacketed glass reactors for pharmaceutical use on our unique free standing movable frame.
    Industrial design, high performing industrial stirring system and connections.

    Main features:
    - Gmp compliant;
    - Total safety: no residues or stagnant liquids;
    - For pharmaceutical...
  • Product Peptide Process Development and Manufacturing

    WuXi STA Peptide platform services include: Process R&D, Manufacturing grams to kilograms peptides under cGMP, Analytical characterization, method development and validation, IPC & release testing, ICH compliant stability studies, Regulatory (CMC) submission support. Our platform support a wide variet...
  • Product Octreotide

    Octreotid Bendalis 0.05 mg/ml
    Octreotid Bendalis 0.1 mg/ml
    Octreotid Bendalis 0.5 mg/ml
    Octreotid Bendalis 0.2 mg/ml



  • Product LACTIUM®

    Lactium® is a milk protein hydrolysate, 100% natural containing a decapeptide with relaxing properties, called alpha-casozepine. Lactium® was discovered by Ingredia’s scientists, in collaboration with Nancy University, in the mid 90ies. The bioactive, result of more than 10 years of research and developme...
  • Product Custom Protein Synthesis

    We provide a Custom Protein Synthesis Service, using a chemical method that synthesises proteins amino acid by amino acid and making modifications on an atomic-scale. We work closely with our partners in designing, customising and optimising the proteins that is synthesized in an automated...
  • Product 2-Cl-Z-Osu

    Novolite Chemicals Co Ltd offers a wide range of products which includes 2-cl-z-osu. Contact us for more information.
  • Product Fmoc-L-Lys[Oct-(otBu)-Glu-(otBu)-AEEA-AEEA]-OH CAS 1662688-20-1

    This product has already in Kilogram production, and the single impurity is not more than 0.2%, total impurity is  not more than 0.5% and the purity can reach more than 98%. We are starting to do the impurities research. This is in pilot scale.
  • Product Lipidated peptides

    Combining smart peptide science and flexible manufacturing capabilities conform GMP - A therapeutic peptide’s pharmacokinetic properties can be improved by linking it to a lipid tail. This form of post-synthesis modification results in a longer life time of the peptide, which increases the chance of cli...
  • Product Collagen Peptides - Our strong brands

    Use one of our strong international GELITA Health brands in license: QYRA®, CH-Alpha®, ShapeUp®, convitar®?
    GELITA Health GmbH develops innovative health products for the international market with proven added value for health, beauty and a better quality of life.
    Our products are based...
  • Product CordenPharma Peptides Platform

    Your Expert Partner for Peptide APIs
    • >> Proven track record delivering world class manufacturing services from early stage to commercial supply, including complex products (e.g., Linaclotide, Enfuvirtide, Mifamurtide, Eptifibatide, Glatiramer, GLP analogues). • >> Proprietary pr...
  • Product Triptorelin Acetate

    Product Name:Triptorelin Acetate;Cas No. 57773-63-4;Sequence Pyr-His-Trp-Ser-Tyr-D-Trp-Leu-Arg-Pro-Gly-NH2;Molecular Formula C64H82N18O13;Molar Mass 1311.5 g/mol;Purity ≥98%;Impurity ≤0.5% ;Storage Temperature 2-8℃;Packing Size 1G/Bottle, 10G/Bottle,50G/Bottle or at customers reqirement.
    Triptorelin Acetat...
  • Product Active pharmaceutical ingredients (APIs)

    High quality APIs to accelerate your generic product launches. Catering to leading innovator and generic companies across the world, Dr. Reddy’s is recognized as one of the largest API suppliers worldwide. The launch of Dr. Reddy’s XCEED – a digital customer service platform - gives customers instant...
  • Product Glatiramer

    AmbioPharm Inc. offers a wide range of products which includes glatiramer. Contact us for more information.
  • Product L-Carnosine

    HAMARI offers a wide range of carnosine derivatives products which includes L-carnosine. Contact us for more information.
  • Product Oligonucleotides/Peptistar®

    NAGASE offers contract manufacturing services for Oligonucleotides APIs through collaboration with PeptiStar Inc.®. PeptiStar®, a technology driven CDMO (Contract Development and Manufacturing Organization), was established in Osaka, Japan in 2017. PeptiStar® offers value-added services by utilizing their...
  • Product Custom Bonding and Chromatography Resins for Small and Large Molecule Purification

    A wide range of DAVISIL® silica gel grades are available from one kg to multi-ton quantities to meet your application, performance, and economic requirements. DAVISIL® silicas are used to purify nutraceuticals, antibiotics, vaccine adjuvants, oil-based APIs, organic synthesis products (including intermediates...
  • Product PRODUCT LIST

    ACTH, Abaloparatide, Alarelin, Angiotensin I/II (1-7), Angiotensin II, Arginine Vasopressin, Atosiban, Buserelin, Carbetocin, Carperitide, Desmopressin, Elcatonin, Eledoisin, Etelcalcetide, Fertirelin, GHRP-6, GLP-1 (7-37), Gonadorelin, Goserelin, Icatibant, Lanreotide, Lecirelin, Leuprolide, Lysine Vasopress...

Peptides

Peptides are small biological molecules that are contained in all living organisms and play several roles within them. As a result of the benefits of these roles, peptides are found in numerous health, cosmetic, and skin products, producing anti-microbial, anti-inflammatory, anti-aging, or muscle building effects in the human body when administered.

Anti-aging properties and other skin health benefits can be found in collagen peptides, while the muscle-building properties can be found in creatine peptide supplements. Creatine peptides, through their effect on the muscles, also help to boost athletic performance. Also, naturally occurring peptides with anti-microbial properties include protregin-1(PG-1), defensins, etc.

Given the many health benefits of peptides, several dietary supplements and drugs contain peptides that are either derived naturally or manufactured. 

Like proteins, peptides are found within every cell, tissue, and organ in the body. However, they are made up of fewer amino acids compared to proteins. Here, let’s quickly examine everything you should know about peptides from how they work to the health benefits they possess.

What are peptides?

Peptides are naturally occurring short strings of amino acids, comprising about 2-50 amino acids linked by peptide bonds. The order and conformation of each biopolymer’s amino acids determine its chemical, biological, and pharmaceutical properties. Combinations of multiple peptide subunits form proteins, and they form one of the basic components of cells that spur and influence biological activities. Based on the number of amino acids in each subunit, peptides are subdivided into oligopeptides (dipeptides, tripeptides, etc.) and polypeptides. Due to their size and configuration, peptides can easily penetrate the skin and intestines’ physiological barriers and are rapidly absorbed into the bloodstream.

What are peptides used for?

Natural and synthetic peptides in prescription drugs, food, supplements, and other healthcare products produce several effects within the body. They are used to delay the aging process, build muscle mass, enhance athletic performance, and hasten the wound healing process.

Bioactive peptides are taking the limelight, and scientists have developed an interest in them because of their benefits to the human body. Based on research, bioactive peptides can be used to kill microbes, inhibit blood clot formation, reduce inflammation, lower blood pressure, and get rid of free radicals (acting as an antioxidant).

What do peptides do to your body?

The functions of peptides within the body are solely dependent on the sequence and types of amino acids within each polymer’s shape. These biologically essential molecules form the structural and fundamental components of cells, tissues, antibiotics, toxins, enzymes, growth factors and hormones. They form the structural framework of cells, make up enzymes that speed up metabolic reactions in the body, form transporters in cell membranes, and serve as precursors to proteins, etc. Therefore, peptides also act as hormones and make up the major component of some of the body’s biological messenger. Hormones are constituted of either steroids or peptides. Peptide hormones are secreted from endocrine glands and are responsible for regulating growth, cardiac function, appetite, response to stress, reproductive functions, etc. They include glucagon, growth hormones, insulin, ghrelin, and several others.

How does peptide therapy work?

Peptides form an essential component of all biological activities, and to maintain homeostasis, appropriate activity levels and concentration of these molecules need to be maintained. Although the human body produces peptides, the amount produced varies by individuals and gradually declines with age.

Peptide therapy is a treatment procedure used to stimulate cell functions specific to a peptide. It is achieved by delivering amino acids to particular cells or areas to stimulate hormones’ production and functions, and regulate and rejuvenate biological pathways, etc. This therapy’s goal isn’t to replace peptides but to take advantage of the communication and signaling system of cells and hormones. For instance, the anti-obesity drug (AOD) 9604, when administered, can enhance bone health, burn fat, and inhibit fat production by stimulating the pituitary gland.

Benefits of peptides in pharmaceuticals

Although proteins’ therapeutic use has long overshadowed peptide therapeutics, there has been growing popularity and interest in the latter. Pharmaceutical researchers have acknowledged the importance of peptide therapeutics and put into cognizance the multiple advantages of peptides. These polymers are better choices compared to synthetic drugs due to their efficacy, safety, and potency.

How do peptides enhance pharmaceuticals?

Peptides, peptide therapy, and therapeutic peptides are rapidly transforming the pharmaceutical industry. Over time, new peptides have been discovered and developed into peptide drugs to treat chronic illnesses such as diabetes, cancer, and cardiovascular diseases. Also, the therapeutic application of peptides for the treatment of other conditions is on the rise. Bioactive peptides have been highly beneficial and have been critically developed to provide health solutions. Defensins developed to kill microbes, glucagon-like peptide (GLP-1) to treat diabetes, ghrelin, treat obese patients, collagen to treat osteoporosis, improve skin health, etc.

Peptides have greatly influenced pharmaceuticals and positively. These naturally occurring polymers are considered better than synthetic drugs in safety, efficacy, selectivity, and specificity. In addition, there were also fewer accumulations, immunogenicity, smaller sizes, and improved solubility.

Peptides are gaining ground and taking pharmaceuticals to a higher and better level, where health is accurately optimized and continually improved. These new-age peptide drugs are considered to be more superior compared to proteins and antibodies.

Through peptides, peptide products, and therapeutic peptides, pharmaceutical companies can provide safe and rapidly acting drugs to treat severe terminal diseases such as cancer, diabetes, and cardiovascular diseases.

As a result of the increasing importance and demand for peptides, several newly developed peptide drugs are currently in clinical trials and at different phases.

How is research advancing the development of peptide products?

In recent years, peptides have spurred a heightened interest in the food, cosmetic, and pharmaceutical industries. Therapeutic peptides and peptide products have risen to become potentially outstanding drug candidates in the pharmaceutical industry. Although peptide products presented with some challenges concerning half-life, bioavailability, safety and peptide synthesis, most of these challenges have been addressed through the traditional therapeutic peptide design.

Over the past years, through research, the medical and biotechnical application of therapeutic peptides has gained ground and covered a wide range. Research into peptide supplements, drugs, and peptide therapeutics has caused these products to take a dimensional change commercially. For example, in 2011, Abbott Laboratories achieved global sales exceeding US$2.3billion on the sales of a peptide-based medicine, Lupron™, for the treatment of prostate cancer.

The value of peptide products and the global peptide drug market generally has spiked massively over the past few years and is expected to attain and surpass US $60 billion by 2026. Through research, the increasing understanding of therapeutic peptides, peptide supplements, and peptide therapy has allowed researchers and manufacturers to produce advanced peptide-drug conjugates to meet the therapeutic and pharmaceutical needs of the clinical setting. Several companies have dived into specialized manufacturing of peptide products, while others specialize in developing these peptide-based products. Pharmaceutical companies now manufacture peptides due to the easy manufacturing process and the rapidly growing global peptide drug market.

The peptide drug market is advancing, and more therapeutic peptides and peptide products have become commercialized. With the ever-evolving technology and in-depth research, new peptides are being discovered regularly and developed in peptide drugs and products.

What are the health benefits of peptides?

Peptides are essential for almost every function and biological activity in the body, and they form the basis for cellular activities. Peptides provide a plethora of benefits, and through peptide-containing health and cosmetic products, these benefits can be amplified. These benefits apply to every organ and system in the body. Collagen peptides boost skin beauty (elasticity and hydration) and health and treat inflammatory diseases such as arthritis. Collagen also helps to facilitate and hasten the wound healing process. Bioactive peptides offer anti-tumor, anti-microbial, antioxidants, antihypertensive, antiallergic, and immunomodulatory benefits to the body. Creatine peptides help to build muscle mass, as well as improve strength and athletic performance. Peptides can be used to treat various conditions and improve the overall health of an individual.

Side effects of peptides

Like every other prescription drug or medication, peptides and peptide supplements have risks and side effects. Peptide supplements and other peptide containing substances are not regulated as strictly as prescription drugs are by the US Food & Drug Administration. Therefore, necessary inquiries and research must be made before ingesting any peptide supplements or peptide containing products. Some of the side effects include skin sensitivity, itching, rashes, dry mouth, joint pain, and fertility problems. When administered to healthy individuals, peptides and peptide supplements are less likely to induce side effects or adverse reactions. However, individuals with underlying conditions would need to seek medical advice before ingesting any of these.

What are the most common side effects of peptides?

The most common side effects of peptides accompany some of its best benefits to the body. For example, Growth hormone secretagogues (GHS) peptides stimulate the release of human growth hormone, boost muscle mass growth, burn fat, and cause some of the most common side effects. They cause fluid retention, elevated blood sugar levels due to reduced insulin sensitivity, and increased appetite. Since most peptides are injected, applied topically to the skin, and inserted trans-dermally, they cause skin irritations, rashes, and itching. Copper- derived peptides are capable of inducing headaches and triggering migraines in some users.

What are the most severe side effects of peptides?

Although peptides rarely result in side effects, they can result in some severe side effects when administered wrongly. Casein peptides administered to lower blood pressure, high cholesterol, etc., can spur severe allergic reactions in lactose-intolerant individuals. Also, they can interfere with blood pressure levels during and after surgery. Orally and intravenously administered copper peptides can result in severe gastrointestinal issues as well as organ-system toxicity. Collagen peptides, which spur collagen production for skin and bone problems, can lower immune defense, trigger allergic reactions, and increase oxidative stress. Contained in collagen peptides is hydrolyzed collagen, which makes absorption and distribution faster.

How common is it for people to have peptide side effects?

Given their similarity to naturally synthesized peptides and their efficacy, safety, and short half-life, peptides rarely give rise to side effects. However, side effects can arise after prolonged use, co-administration of peptides with some prescription drugs, or administration of peptide supplements to individuals with underlying conditions.

Safety in prescribing peptides with other drugs

Although peptides are generally safe, they can pose serious health risks to users. Therapeutic peptides, peptide therapy, and peptide supplements can worsen underlying health conditions, interact with prescription drugs, and cause severe adverse reactions. Every prescription made comes with ethical, legal, and clinical responsibilities. The doctor’s job is to ensure that the therapeutic peptides or supplements prescribed are safe, prescribed within therapeutic standards, and compatible with co-administered drugs or underlying health conditions such as cancer.

How common are drug interactions with peptides?

Peptide supplements are usually naturally occurring or at least similar to the naturally occurring peptides. For this reason, they are considered safe and would rarely give rise to drug-drug interactions when co-administered with other drugs.

Which prescriptions are not safe to combine with peptide therapy?

Prescription drugs are considered unsafe to combine with peptide therapy based on the peptide that is to be administered or prescribed. These combinations are considered unsafe due to adverse reactions arising from drug interactions. Drugs that target the same peptide receptors as peptide drugs are considered dangerous for co-administration. For example, casein peptides co-administered with high blood pressure drugs such as enalapril or amlodipine, can cause a drastic fall in blood pressure levels.

Prescription drugs, such as indomethacin and naltrexone, which affect the oral bioavailability of peptide drugs such as Bremelanotide, are considered unsafe for combinations. Also, the use of anabolic steroids alongside some specific peptides can be detrimental to the recipient’s health.

How can you tell if peptides are causing a drug interaction?

Like every other drug-drug interaction, peptide-drug interactions occur at pharmacodynamic and pharmacokinetic levels. That is a peptide, and drug interaction can occur at the receptor sites, during absorption, or distribution. Drug-peptide interaction can be identified by manifesting symptoms of adverse effects, such as water intoxication, increased blood sugar levels, and severe pain, or by reducing or exaggerating the intended drug or peptide effect. These interactions can arise due to the wrong dosage, administration of medications through the wrong route, or wrong drug choice.

Considering how important the role peptides play in living organisms is, understanding what it is and how it is composed is very important. Not only do peptides interact with drugs, but there are also several instances where they cause drug interactions. Like every other product, peptides come with some benefits as much as they have their side effects. Some of the benefits include facilitating skincare and improving response to certain drugs. In-depth research and maximum care have to be exercised when administering peptide supplements. To be sure you are on the safe side, you should speak to a doctor immediately if any side effect is detected from the use of peptides or peptide supplements.

 

References

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