AMP™- Biopredictive Dissolution Testing of MR drugs

The loVol®  is a specialized system engineered for low-volume solubility and dissolution testing. Designed for early-stage drug development and formulation screening, loVolr evaluates APIs, powder mixtures, granules, coated pellets, and finished oral dosage forms under both constant pH and dynamic pH ...

AMP™ (Advanced Modular Platform) is the first system to deliver precise, customizable simulations of dynamic in vivo conditions. Built around a universal core system with interchangeable test modules, AMP™ realistically mimics gastrointestinal transit by combining:

• Dynamic mechanical and phys...

Our PhysioCell: 

 - simulates crucial conditions of the upper GIT and is based on three-compartmental flow-through construction,


- features simulation of: gastric motility, constant or variable kinetics of the gastric emptying of non-caloric liquids, temperature gradients of the...

Compass® is a Python-based software that predicts in vivo similarity of immediate-release oral dosage forms by combining semi-mechanistic modeling with user-provided dissolution and pharmacokinetic data.
Compass® fits a modified Noyes–Whitney model, simulates plasma concentration–time pr...

The pHysio-grad® device: 
- Can precisely monitor and adjust the pH value of commonly used hydrogen carbonate buffers the pH adjustment in the range of pH 5.5 to 8.3 with a maximum deviation of ± 0.02 pH units.

- Utilizes pure CO2 and inert gases for simulation of intestinal condi...

The DoSampler is a versatile autosampler designed to complement pHysio-grad® and AMP systems, or operate in standalone mode. 

It enables precise, automated sampling into HPLC vials or glass tubes using high-accuracy syringe pumps.With support for up to 12 channels and the ability to collect up ...

Key Capabilities

- Simulation of proximal GI tract: Replicates dynamic pressure events, pH shifts, flow rates, and thermal gradients.


- Intestinal Realism: Simulates rapid duodenal neutralization and dynamic carbonate buffer interactions


- Integrated PK Insights: Driven by prop...

Our pharmacokinetic services include: 

- interpretation of the results of pharmacokinetic studies and physiological mechanisms affecting the pharmacokinetic characteristics of oral drugs; 

- creating pharmacokinetic and biopharmaceutics models and IVIV correlations and extrapola...

We offer: 

- Chemical Stability Screening that includes the check on the API robustness across gastric and intestinal pH ranges, including nutrient-rich fed-state media such as milk, lipid emulsions, and simulated chyme.

- Check on Enzymatic Degradation that determines API bre...

We provide support in developing analytical methods using UV-VIS spectroscopy, High-Performance Liquid Chromatography, and Ultra-Performance Liquid Chromatography for the quantification of small molecules and biomolecules. Our particular strength lies in creating robust methods for samples in complex disso...

The disintegration test holds a special place at Physiolution. This simple, yet powerful experiment provides answers to big questions: does the formulation disintegrate well if the temperature gradient of the dissolution medium is applied? Or when the medium has a composition and a consistency of a digeste...

Key Capabilities of our Services are:

- Low-Volume Efficiency: Conducts robust solubility studies in small working volumes to conserve API, excipients, and costly reagents.


- Biorelevant pH Gradient Simulation: Integrates seamlessly with pHysio-grad® to perform two-stage testing, manage h...