Biomolecules Oral Feasibility & Gastrointestinal Stability Testing

We offer: 

- Chemical Stability Screening that includes the check on the API robustness across gastric and intestinal pH ranges, including nutrient-rich fed-state media such as milk, lipid emulsions, and simulated chyme.

- Check on Enzymatic Degradation that determines API breakdown in the presence of pepsin and pancreatin using dynamic pH gradients, two-stage digestion models, and physiological temperature conditions.

- Predictive Hydrolysis Modeling that integrates high-quality experimental data into a validated model simulating fasted and fed states, including edge-case scenarios and intragastric pH fluctuations.

The outcome of the tests is a precise hydrolysis model describing the API performance under dosing conditions.