Feasibility Screening of APIs for Oral Delivery
Product Description
Physiolution Polska sp. z o. o.
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Country/Region:Poland
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Founded:2009
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On CPHI since:2026
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Certificates:1
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Employees:1 - 24
Company types
Primary activities
Categories
Specifications
Physiolution Polska sp. z o. o.
-
Country/Region:Poland
-
Founded:2009
-
On CPHI since:2026
-
Certificates:1
-
Employees:1 - 24
Company types
Primary activities
More Products from Physiolution Polska sp. z o. o. (14)
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Product PhysioCell®: Biopredictive Dissolution Testing of IR drugs
Key Capabilities
- Simulation of proximal GI tract: Replicates dynamic pressure events, pH shifts, flow rates, and thermal gradients.
- Intestinal Realism: Simulates rapid duodenal neutralization and dynamic carbonate buffer interactions
- Integrated PK Insights: Driven by prop... -
Product PK simulations and modelling
Our pharmacokinetic services include:
- interpretation of the results of pharmacokinetic studies and physiological mechanisms affecting the pharmacokinetic characteristics of oral drugs;
- creating pharmacokinetic and biopharmaceutics models and IVIV correlations and extrapola... -
Product Biomolecules Oral Feasibility & Gastrointestinal Stability Testing
We offer:
- Chemical Stability Screening that includes the check on the API robustness across gastric and intestinal pH ranges, including nutrient-rich fed-state media such as milk, lipid emulsions, and simulated chyme.
- Check on Enzymatic Degradation that determines API bre... -
Product Analytical Method Development & Characterization
We provide support in developing analytical methods using UV-VIS spectroscopy, High-Performance Liquid Chromatography, and Ultra-Performance Liquid Chromatography for the quantification of small molecules and biomolecules. Our particular strength lies in creating robust methods for samples in complex disso... -
Product Spontaneous Disintegration Testing
The disintegration test holds a special place at Physiolution. This simple, yet powerful experiment provides answers to big questions: does the formulation disintegrate well if the temperature gradient of the dissolution medium is applied? Or when the medium has a composition and a consistency of a digeste... -
Product Small-Scale API, Excipient & Formulation Characterization
Key Capabilities of our Services are:
- Low-Volume Efficiency: Conducts robust solubility studies in small working volumes to conserve API, excipients, and costly reagents.
- Biorelevant pH Gradient Simulation: Integrates seamlessly with pHysio-grad® to perform two-stage testing, manage h... -
Product Determination of microenvironmental pH
Understanding the formation and stability of microenvironmental pH is essential for predicting dosage form performance. Our specialized test protocol uses a pH indicator or microelectrodes in the dissolution medium to visualize pH shifts near the formulation surface or within its cross-section. We also mon... -
Product loVol®
The loVol® is a specialized system engineered for low-volume solubility and dissolution testing. Designed for early-stage drug development and formulation screening, loVolr evaluates APIs, powder mixtures, granules, coated pellets, and finished oral dosage forms under both constant pH and dynamic pH ... -
Product Advanced Modular Platform (AMP™ )
AMP™ (Advanced Modular Platform) is the first system to deliver precise, customizable simulations of dynamic in vivo conditions. Built around a universal core system with interchangeable test modules, AMP™ realistically mimics gastrointestinal transit by combining:
• Dynamic mechanical and phys... -
Product PhysioCell
Our PhysioCell:
- simulates crucial conditions of the upper GIT and is based on three-compartmental flow-through construction,
- features simulation of: gastric motility, constant or variable kinetics of the gastric emptying of non-caloric liquids, temperature gradients of the... -
Product Compass®
Compass® is a Python-based software that predicts in vivo similarity of immediate-release oral dosage forms by combining semi-mechanistic modeling with user-provided dissolution and pharmacokinetic data.
Compass® fits a modified Noyes–Whitney model, simulates plasma concentration–time pr... -
Product pHysio-grad
The pHysio-grad® device:
- Can precisely monitor and adjust the pH value of commonly used hydrogen carbonate buffers the pH adjustment in the range of pH 5.5 to 8.3 with a maximum deviation of ± 0.02 pH units.
- Utilizes pure CO2 and inert gases for simulation of intestinal condi...