Copper-Mediated N-Arylations of Hydantoins

4 Mar 2019

MINAKEM RECHERCHE has collaborated with the research group of Prof. Gwilherm Evano, from the ULB to develop a flexible approach towards N-arylated hydantoins. We are very pleased to announce that the publication has been approved in the Journal of Organic Chemistry.

MINAKEM RECHERCHE has collaborated with the research group of Prof. Gwilherm Evano, from the ULB to develop a flexible approach towards N-arylated hydantoins. We are very pleased to announce that the publication has been approved in the Journal of Organic Chemistry.

Copper-Mediated N-Arylations of Hydantoins

 Abstract

A set of two efficient and broadly applicable procedures for the N-arylation of hydantoins at the two nitrogen atoms is reported. The first one relies on the use of stoichiometric amounts of copper(I) oxide under ligandless and base-free conditions and enables a clean and regioselective arylation at the N3 nitrogen atom while the second one is based on the use of catalytic amounts of copper(I) iodide and trans-N, N′-dimethylcyclohexane -1,2-diamine and promotes arylation at the N1 nitrogen atom. Importantly, the combination of these two procedures affords a straightforward and general entry to diarylated hydantoins.

Access the full article now: https://pubs.acs.org/doi/10.1021/acs.joc.8b02284
Authors: Pierre Thilmany, Phidéline Gérard, Agathe Vanoost, Christopher Deldaele, Laurent Petit, and Gwilherm Evano

Feel free to get in contact with our Research team: [email protected] 

Source:  J. Org. Chem., Just Accepted ManuscriptDOI: 10.1021/acs.joc.8b02284Publication Date (Web): November 9, 2018Copyright © 2018 American Chemical Society

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